What is Leukine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Leukine overview

BRAND NAMES:

  • Leukine

Generic Names:

  • Leukine

Uses:

  • Helps your body make white blood cells after you receive cancer medicine, bone marrow transplant, or stem cell transplant. Also used to move cells into the blood for collection before a transplant and to improve survival in people who have been exposed to radiation.

Therapeutic Classes:

  • Hematopoietic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Leukine used for?

Leukine is a man-made version of a certain natural substance made in your body. It is used in the prevention of serious infection in conditions such as leukemia, bone marrow transplant, and pre-chemotherapy blood cell collection. It is used also to increase the number of white blood cells. White blood cells are important to help you fight off infections.

What form(s) does Leukine come in

  • Injectable

What are common Leukine doses?

  • Solution Reconstituted 250MCG

Common Leukine prescriptions

  • Leukine
    250mcg solution reconstituted

How to take Leukine

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Injection routeIf you store this medicine at home, keep it in the refrigerator. Do not freeze. Keep this medicine in its original container. You may store the opened vials in the refrigerator for up to 20 days. Throw away unused medicine after 20 days. The powder has different storage directions based on what kind of liquid it was mixed.

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin or into a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • This medicine is available in two different forms: premixed liquid or a powder. You might be able to use the premixed liquid directly from the vial, or you might have to mix it with another liquid before you use it. You must mix the powder with another liquid before using it.

  • If you will be giving this medicine to yourself as a shot under your skin: Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into areas where the skin is tender, bruised, red, hard, or has scars or stretch marks.

  • Check the liquid inside the vial. It should be clear and colorless. Do not use it if it is cloudy, discolored, or has particles in it.

  • Injection routeUse a new needle and syringe each time you inject your medicine. Do not shake the medicine.

  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Check the liquid inside the vial. It should be clear and colorless. Do not use it if it is cloudy, discolored, or has particles in it.

  • If you will be giving this medicine to yourself as a shot under your skin: Injection routeYou will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into areas where the skin is tender, bruised, red, hard, or has scars or stretch marks.

  • Injection routeA nurse or other health provider will give you this medicine.

  • This medicine is available in two different forms: premixed liquid or a powder. You might be able to use the premixed liquid directly from the vial, or you might have to mix it with another liquid before you use it. You must mix the powder with another liquid before using it.

  • Injection routeUse a new needle and syringe each time you inject your medicine. Do not shake the medicine.

  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin or into a vein.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Injection routeIf you store this medicine at home, keep it in the refrigerator. Do not freeze. Keep this medicine in its original container. You may store the opened vials in the refrigerator for up to 20 days. Throw away unused medicine after 20 days. The powder has different storage directions based on what kind of liquid it was mixed.

What to do if you miss a dose of Leukine

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, pharmacist, or treatment clinic for instructions.

  • Ask your pharmacist, doctor, or nurse about how to store your medicine after you have opened a vial (bottle). The pre-mixed liquid can usually be stored for up to 20 days after the vial has been opened. The powder has different storage directions based on what kind of liquid it is mixed with.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Leukine contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to sargramostim or similar medicines, yeast, or anything made from yeast.

Leukine warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Swelling in your hands, ankles, or feet, or rapid weight gain.

  • Tell your doctor if you are pregnant. This medicine contains benzyl alcohol, which can be harmful to infants and unborn babies.

  • Do not breastfeed during treatment with this medicine and for at least 2 weeks after your last dose.

  • Tell your doctor if have kidney disease, liver disease, edema (fluid retention), heart disease, heart failure, heart rhythm problems, or lung disease or other breathing problems.

  • This medicine may cause the following problems:Infusion reactionsCapillary leak syndromeChanges in heart rhythmIncreased number of white blood cells in the bloodIncreased risk of cancer

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Leukine interactions

  • Some medicines can affect how sargramostim works. Tell your doctor if you are using a medicine that can increase the number of cells in your blood (including lithium, steroid medicine).

  • If your cancer symptoms get worse, call your doctor.

  • If you are also receiving cancer medicines or radiation treatments, use sargramostim at least 24 hours before or after receiving cancer medicines and at least 24 hours before your dose of radiation treatment.

Leukine side effects

Serious Side Effects

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual bleeding, bruising, or weakness

  • Decrease in how much or how often you urinate, cloudy urine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blue lips or fingers

  • Chest pain, trouble breathing

  • Fast or uneven heartbeat

  • Lightheadedness, dizziness, or fainting

  • Warmth or redness in your face, neck, arms, or upper chest

Less Serious Side Effects

  • Nausea, vomiting, diarrhea, loss of appetite

  • Hair loss or thinning of hair

  • Redness, pain, or swelling where the injection was given.

  • Redness, pain, or swelling where the injection was given

  • Bone, joint, or muscle pain

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