What is Lidocaine Plus: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

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Lidocaine Plus overview

BRAND NAMES:

  • Aspercreme, Astero, Bengay, Blue Tube, Burnamycin, Burn Relief, CidalEaze, Corta-Cap Needle Ease, Eha, First Care Pain Relief Gel Patch, Anecream, Anastia, Alocane Emergency Burn Spray, Alocane Emergency Burn, 7T Lido Gel

Generic Names:

  • Lidocaine Hcl

Uses:

  • Numbs the skin and relieves pain caused by shingles or other conditions. Treats urethritis and prevents and controls pain in procedures involving the male and female urethra. Also numbs and lubricates the nose, mouth, and throat for intubation. This medicine is a topical anesthetic.

Therapeutic Classes:

  • Analgesic, Anesthetic, Local

Forms:

  • Foam, Cream, Patch, Ointment, Pad, Lotion, Liquid, Gel/Jelly, Spray

How it’s taken:

  • On the skin

What is Lidocaine Plus used for?

What form(s) does Lidocaine Plus come in

  • Foam

  • Cream

  • Patch

  • Ointment

  • Pad

  • Lotion

  • Liquid

  • Gel/Jelly

  • Spray

What are common Lidocaine Plus doses?

  • Tube 120GM of 4%

How to take Lidocaine Plus

  • Fold the used patch in half with the sticky sides together. Throw any used patch away so that children or pets cannot get to it.

  • Use this medicine as directed. Do not use more medicine or use it more often than your doctor tells you to.

  • Do not get this medicine into your eyes. If it does get into your eyes, rinse with water or saline solution right away.

  • Do not apply this medicine to open wounds, burns, broken or inflamed skin, or to a large area of skin unless directed by your doctor.

  • Patch: Transdermal routeWash your hands with soap and water before and after applying a patch. Do not use the patch if it is damaged. Throw it away and get a new one.You may also cut the patch into smaller sizes with scissors before removing the patch release liner.Apply the patch right away to clean, dry, and intact skin. Transdermal routeDo not put the patch over burns, cuts, or irritated skin. Transdermal routePut on a new patch if the old one has fallen off and cannot be reapplied. The patch will not stick if it gets wet. Do not wear it when you take a bath or shower, or when you go swimming.You may also use the Ztlido„¢ patch during moderate exercise, including biking for 30 minutes.You may apply up to 3 Ztlido„¢ patches at a time. Do not wear the patch for longer than 12 hours in any 24-hour period.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • Do not eat or drink for at least 1 hour after you use this medicine in your mouth or throat. Do not chew gum or food while your mouth or throat feels numb.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Do not eat or drink for at least 1 hour after you use this medicine in your mouth or throat. Do not chew gum or food while your mouth or throat feels numb.

  • Do not get this medicine into your eyes. If it does get into your eyes, rinse with water or saline solution right away.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Patch: Transdermal routeWash your hands with soap and water before and after applying a patch. Do not use the patch if it is damaged. Throw it away and get a new one.You may also cut the patch into smaller sizes with scissors before removing the patch release liner.Apply the patch right away to clean, dry, and intact skin. Transdermal routeDo not put the patch over burns, cuts, or irritated skin. Transdermal routePut on a new patch if the old one has fallen off and cannot be reapplied. The patch will not stick if it gets wet. Do not wear it when you take a bath or shower, or when you go swimming.You may also use the Ztlido„¢ patch during moderate exercise, including biking for 30 minutes.You may apply up to 3 Ztlido„¢ patches at a time. Do not wear the patch for longer than 12 hours in any 24-hour period.

  • Fold the used patch in half with the sticky sides together. Throw any used patch away so that children or pets cannot get to it.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Use this medicine as directed. Do not use more medicine or use it more often than your doctor tells you to.

  • Do not apply this medicine to open wounds, burns, broken or inflamed skin, or to a large area of skin unless directed by your doctor.

What to do if you miss a dose of Lidocaine Plus

Lidocaine Plus contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to lidocaine or similar medicines.

Lidocaine Plus warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Do not use a heating pad, electric blanket, or any other heat source over the patch. However, you may apply Ztlido„¢ patch on the skin after exposure to a moderate heat setting.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart problems, lung or breathing problems, porphyria (enzyme problem), a blood disorder, G6PD, or epilepsy.

  • This medicine may cause methemoglobinemia (blood disorder).

  • Do not give lidocaine solution to a child younger than 3 years of age for teething pain, unless your doctor says it is okay.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Lidocaine Plus interactions

  • Some medicines can affect how lidocaine works. Tell your doctor if you are using any of the following:Acetaminophen, chloroquine, metoclopramide, primaquine, quinine, sulfasalazineCancer medicine (including cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase)Medicine for heart rhythm problems (including amiodarone, mexiletine, tocainide)Medicine to treat an infection (including dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamide)Medicine to treat seizures (including phenobarbital, phenytoin, sodium valproate)Nitrate or nitrite medicine (including nitric oxide, nitroglycerin, nitroprusside, nitrous oxide)

  • Do not give lidocaine solution to a child younger than 3 years for teething pain, unless your doctor says it is okay.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Lidocaine Plus side effects

Serious Side Effects

  • Tremor or seizures

  • Confusion, dizziness, drowsiness, lightheadedness

  • Blurred or double vision

  • Slow, fast, or uneven heartbeat

  • Troubled or shallow breathing, trouble swallowing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Pale, gray, or blue lips, nails, or skin, dark urine, headache, unusual tiredness or weakness

Less Serious Side Effects

  • Eye irritation, sore eyes

  • Redness, itching, burning, swelling, or blisters where the patch is applied

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