Mesna overview
BRAND NAMES:
Mesnex, PremierPro Rx Mesna, PremierPro Rx Mesna
Generic Names:
Mesna
Uses:
Lowers the risk of inflammation and bleeding of the bladder in patients who receive ifosfamide (cancer medicine).
Therapeutic Classes:
Hemorrhagic Cystitis Inhibitor
Forms:
Injectable
How it’s taken:
By injection
What is Mesna used for?
Mesnex is an antineoplastic detoxifying agent used to minimize the side effects of chemotherapy. It prevents hemorrhagic cystitis that is caused by the use of ifosfamide, a chemotherapeutic drug. Mesnex forms a protective lining in the bladder to protect it from damage by ifosfamide. It may be used to treat other conditions as prescribed by your doctor. Mesnex is available as a tablet and injection.
What form(s) does Mesna come in
Injectable
What are common Mesna doses?
Vial 10ML of 100MG/ML
Common Mesna prescriptions
Mesna
10ml of 100mg/ml vial
How to take Mesna
Missed dose: Injection routeCall your doctor or pharmacist for instructions.
Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
Injection routeA nurse or other health provider will give you this medicine.
Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink 1 to 2 liters of fluid each day.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink 1 to 2 liters of fluid each day.
Injection routeA nurse or other health provider will give you this medicine.
Missed dose: Injection routeCall your doctor or pharmacist for instructions.
Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
What to do if you miss a dose of Mesna
Mesna contraindications
This medicine is not right for everyone. You should not receive it if you had an allergic reaction to mesna. This medicine contains benzyl alcohol and should not be given to premature or low-birth weight babies.
Mesna warnings
This medicine is used together with ifosfamide. Ifosfamide can harm your unborn baby while you are pregnant. It may also cause birth defects if the father is receiving it when his sexual partner becomes pregnant. Use an effective form of birth control during treatment with this medicine in combination with ifosfamide and for 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 3 months after the last dose.
Do not breastfeed during treatment with this medicine and for 1 week after the last dose.
Tell your doctor if you have a history of an allergic reaction to thiol compounds (including amifostine).
This medicine may cause serious skin reactions.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Unusual bleeding, bruising, or weakness
Mesna interactions
Tell your doctor if you are pregnant or breastfeeding, or if you have a history of an allergic reaction to thiol compounds.
This medicine may cause serious skin reactions.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Mesna side effects
Serious Side Effects
Red or pink urine
Lightheadedness, dizziness, fainting
Unusual bleeding, bruising, or weakness
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, red skin rash
Chest pain, trouble breathing, fast or uneven heartbeat
Fever, chills, cough, sore throat, body aches
Less Serious Side Effects
Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
Loss or thinning of hair
Loss of appetite, nausea, vomiting
Unusual drowsiness or tiredness
Diarrhea, constipation, stomach pain
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