What is Mesnex: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Check our best Mesnex prices

Mesnex overview

BRAND NAMES:

  • Mesnex, PremierPro Rx Mesna, PremierPro Rx Mesna, Mesnex

Generic Names:

  • Mesnex

Uses:

  • Lowers the risk of inflammation and bleeding of the bladder in patients who receive ifosfamide (cancer medicine)., Lowers the risk of inflammation and bleeding of the bladder in patients who receive ifosfamide (cancer medicine).

Therapeutic Classes:

  • Hemorrhagic Cystitis Inhibitor, Hemorrhagic Cystitis Inhibitor

Forms:

  • Tablet, Injectable

How it’s taken:

  • By injection, By mouth

What is Mesnex used for?

Mesnex is an antineoplastic detoxifying agent used to minimize the side effects of chemotherapy. It prevents hemorrhagic cystitis that is caused by the use of ifosfamide, a chemotherapeutic drug. Mesnex forms a protective lining in the bladder to protect it from damage by ifosfamide. It may be used to treat other conditions as prescribed by your doctor. Mesnex is available as a tablet and injection.

What form(s) does Mesnex come in

  • Tablet

  • Injectable

What are common Mesnex doses?

  • Tablet 400MG

Common Mesnex prescriptions

  • Mesnex
    400mg tablet

  • Mesnex
    10ml of 100mg/ml vial

How to take Mesnex

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink 1 to 2 liters of fluid each day.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink 1 to 2 liters of fluid each day.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Missed dose: Injection routeCall your doctor or pharmacist for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink 1 to 2 liters of fluid each day.

  • Call your doctor if you vomit within 2 hours after you take this medicine.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Call your doctor if you vomit within 2 hours after you take this medicine.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems. Drink 1 to 2 liters of fluid each day.

What to do if you miss a dose of Mesnex

Mesnex contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to mesna. This medicine contains benzyl alcohol and should not be given to premature or low-birth weight babies.

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to mesna.

Mesnex warnings

  • This medicine is used together with ifosfamide. Ifosfamide can harm your unborn baby while you are pregnant. It may also cause birth defects if the father is receiving it when his sexual partner becomes pregnant. Use an effective form of birth control during treatment with this medicine in combination with ifosfamide and for 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 3 months after the last dose.

  • Do not breastfeed during treatment with this medicine and for 1 week after the last dose.

  • Tell your doctor if you have a history of an allergic reaction to thiol compounds (including amifostine).

  • This medicine may cause serious skin reactions.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Unusual bleeding, bruising, or weakness

  • This medicine is used together with ifosfamide. Ifosfamide can harm your unborn baby while you are pregnant. It may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Use an effective form of birth control during treatment with this medicine in combination with ifosfamide and for 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 3 months after the last dose.

  • Do not breastfeed during treatment with this medicine or ifosfamide and for 1 week after the last dose.

  • Tell your doctor if you have a history of allergic reaction to thiol compounds (including amifostine).

  • This medicine may cause serious skin reactions.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Mesnex interactions

  • Tell your doctor if you are pregnant or breastfeeding, or if you have a history of allergic reaction to thiol compounds.

  • This medicine may cause serious skin reactions.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have a history of an allergic reaction to thiol compounds.

  • This medicine may cause serious skin reactions.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Mesnex side effects

Serious Side Effects

  • Red or pink urine

  • Fever, chills, cough, sore throat, body aches

  • Unusual bleeding, bruising, or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Chest pain, trouble breathing, fast or uneven heartbeat

  • Lightheadedness, dizziness, fainting

  • Red or pink urine

  • Lightheadedness, dizziness, fainting

  • Unusual bleeding, bruising, or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Chest pain, trouble breathing, fast or uneven heartbeat

  • Fever, chills, cough, sore throat, body aches

Less Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Loss or thinning of hair

  • Loss of appetite, nausea, vomiting

  • Unusual drowsiness or tiredness

  • Diarrhea, constipation, stomach pain

  • Diarrhea, constipation, stomach pain

  • Loss of appetite, nausea, vomiting

  • Unusual drowsiness or tiredness

  • Loss or thinning of hair

Browse drugs A-Z:

View all
ABCDEFGHIJKLMNOPQRSTUVWXYZ

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.