What is Mexiletine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Mexiletine overview

BRAND NAMES:

Generic Names:

  • Mexiletine Hcl

Uses:

  • Treats an irregular heartbeat (arrhythmia). Belongs to a class of drugs called antiarrhythmics.

Therapeutic Classes:

  • Antiarrhythmic, Group IB

Forms:

  • Capsule, Long Acting Capsule

How it’s taken:

  • By mouth

What is Mexiletine used for?

What form(s) does Mexiletine come in

  • Capsule

  • Long Acting Capsule

What are common Mexiletine doses?

  • Capsule 150MG

  • Capsule 200MG

  • Capsule 250MG

Common Mexiletine prescriptions

  • Mexiletine HCl
    150mg capsule

  • Mexiletine HCl
    200mg capsule

  • Mexiletine HCl
    250mg capsule

How to take Mexiletine

  • Your doctor will tell you how much to use and how often. Do not use more medicine or use it more often than your doctor tells you to.

  • May be taken with food, milk, or antacids to avoid stomach upset.

  • You may need to carry identification to let others know you are using mexiletine. Ask your doctor about this.

  • Your doctor will tell you how much to use and how often. Do not use more medicine or use it more often than your doctor tells you to.

  • May be taken with food, milk, or antacids to avoid stomach upset.

  • You may need to carry identification to let others know you are using mexiletine. Ask your doctor about this.

What to do if you miss a dose of Mexiletine

  • If you use mexiletine 3 times daily and you miss a dose, take your medicine as soon as possible if you are less than 4 hours late. If you use the medicine twice a day, take the missed dose as soon as possible if you are less than 6 hours late.

  • Otherwise, skip the missed dose and go back to your regular dosing schedule.

  • You should not use two doses at the same time.

Mexiletine contraindications

  • You should not use this medicine if you have ever had an allergic reaction to mexiletine, lidocaine, or tocainide. This drug should not be used with some heart disorders, liver disease, or seizures - check with your doctor.

Mexiletine warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, liver disease, seizures, or low blood pressure.

  • Tell your doctor or dentist that you are using mexiletine before having any kind of surgery.

  • Do not suddenly stop using this medicine without asking your doctor.

  • Mexiletine may make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

Mexiletine interactions

  • Do not smoke while using this medicine.

  • Tell your doctor if you are also using phenytoin (Dilantin®), or other heart medicines such as lidocaine or digoxin (Lanoxin®).

  • Do not suddenly stop using this medicine without asking your doctor.

  • Mexiletine may make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

Mexiletine side effects

Serious Side Effects

  • Irregular heartbeat

  • Chest pain

  • Blurred vision

  • Tiredness or weakness

  • Shortness of breath or trouble breathing

  • Skin rash, severe itching or hives

Less Serious Side Effects

  • Trembling or shaking of hands

  • Dizziness, lightheadedness, or nervousness

  • Diarrhea or constipation

  • Tiredness or weakness

  • Nausea, vomiting, or upset stomach

  • Blurred vision