Nikki is a birth control pill used to prevent pregnancy. It contains a combination of synthetic estrogen and a progestin. The generic version of this birth control is drospirenone-ethinyl estradiol. The retail price of Nikki is about $93.88 for 1, 1 package (28 tablets), 3-0.02mg disp pack, but SingleCare's lowest price is $6.20 for 1, 1 package (28 tablets), 3-0.02mg disp pack of generic Nikki. Use one of the Nikki coupons below to save on your prescription today.
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About SingleCare Pricing
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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About Nikki
Nikki is a birth control pill used to prevent pregnancy. It contains a combination of synthetic estrogen and a progestin. The generic version of this birth control is drospirenone-ethinyl estradiol. The retail price of Nikki is about $93.88 for 1, 1 package (28 tablets), 3-0.02mg disp pack, but SingleCare's lowest price is $6.20 for 1, 1 package (28 tablets), 3-0.02mg disp pack of generic Nikki. Use one of the Nikki coupons below to save on your prescription today.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
Average 1-Month Prices for Nikki (Trademark Generic) & Drospirenone-Ethinyl Estradiol (Generic)
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
About Nikki
Nikki is a birth control pill used to prevent pregnancy. It contains a combination of synthetic estrogen and a progestin. The generic version of this birth control is drospirenone-ethinyl estradiol. The retail price of Nikki is about $93.88 for 1, 1 package (28 tablets), 3-0.02mg disp pack, but SingleCare's lowest price is $6.20 for 1, 1 package (28 tablets), 3-0.02mg disp pack of generic Nikki. Use one of the Nikki coupons below to save on your prescription today.
Without insurance coverage, the average cost of Nikki is around $93.88 for 1, 1 package (28 tablets), 3-0.02mg disp pack. SingleCare can help you save on this total with a Nikki discount card. Pay only $6.20 for 1, 1 package (28 tablets), 3-0.02mg disp pack of generic Nikki prescription refill at participating pharmacies, such as CVS, Target, Walmart, and Walmart among others.
How much does Nikki cost with insurance?
Commercial healthcare plans typically offer Nikki at varying prices, based on the type of plan you have and your level of coverage. You can find your exact Nikki cost by visiting your local pharmacist and asking for assistance. You may be able to save even more on your Nikki purchases by using SingleCare's Nikki prescription discount cards instead of insurance. Compare our lowest price of $6.20 for 1, 1 package (28 tablets), 3-0.02mg disp pack of generic Nikki to your copay before you overpay for another prescription.
Does Medicare cover Nikki and how much does it cost?
Nikki is currently covered by the majority of Medicare plans including Medicare Part D and Medicare Advantage plans. Your copay for Nikki with Medicare could still cost over $50. Reduce your out-of-pocket expenses and spend as little as $6.20 on Nikki when you use a SingleCare savings card at participating drugstores near you.
Is there a generic of Nikki?
Nikki is a brand-name prescription drug manufactured by Lupin Pharmaceuticals, Inc. The generic version of this drug is drospirenone-ethinyl estradiol.
What is Nikki?
Nikki is an FDA-approved prescription medication used to prevent pregnancy. This medication contains a combination of ethinyl estradiol, an estrogen, and drospirenone, a progestin. It works mainly by preventing the release of an egg, or ovulation, during a menstrual cycle. It can also change the consistency of cervical mucus to prevent sperm from reaching an egg. If a fertilized egg is unable to attach to the uterus, it is passed out of the body. This medication may also be used to treat premenstrual dysphoric disorder and acne in certain women.
Nikki comes in the form of an oral tablet that can be taken once daily, with or without meals. Taking this medication after your evening meal or before you go to sleep may help decrease an upset stomach and nausea. Consult your healthcare provider and follow the instructions provided on the product packaging before you start using this medication.
It is recommended to use a non-hormonal form of birth control, such as condoms or spermicide, during the first week of Nikki use. This will help prevent pregnancy until the medication has enough time to work. If you start this medication on the first day of your period, then you do not need to use back-up birth control during the first week.
What are the side effects of Nikki?
Nikki may cause side effects such as nausea, vomiting, bloating, headaches, breast tenderness, swelling of the ankles, or weight changes. You may also experience vaginal bleeding between periods (spotting), especially during the first few months of use. Speak with your doctor or pharmacist if you experience side effects that persist or worsen.
This medication may increase the risk of blood clots, which can lead to serious cardiovascular events like heart attacks and strokes. Tell your doctor if you have a history of heart disease or smoking before using Nikki.
Women who have a history of breast cancer should avoid the use of Nikki. This medication may increase the risk of breast and cervical cancer in some women.
Tell your doctor if you have a history of high blood pressure, liver problems, or depression before taking Nikki. Consult your healthcare provider for other possible side effects, warnings, and precautions before taking this medication.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Where are Nikki coupons from SingleCare accepted?
SingleCare is accepted at most national pharmacies and grocers, including the following: