What is Migergot? Uses, warnings & side effects

Updated May 14, 2025  •  Published Jun 17, 2021

Migergot overview

BRAND NAMES:

  • Migergot

Generic Names:

  • Migergot

Uses:

  • Treats or prevents migraine and cluster headaches.

Therapeutic Classes:

  • Ergot Alkaloid Combination

Forms:

  • Suppository

How it’s taken:

  • Into the rectum

What is Migergot used for?

Migergot is used to treat migraines. It helps narrow widened blood vessels in the head, which reduces the throbbing effects of vascular headaches. Migergot will only work if it is taken after the migraine has started. It will not prevent prevent migraines from occuring.

What form(s) does Migergot come in?

  • Suppository

What are common Migergot dosages?

  • Box 12 Suppository

Migergot images - What does Migergot look like?

  • Migergot
    12 suppository box

How to take Migergot

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to. Never take rectal suppositories by mouth.

  • Wash your hands with soap and water before using this medicine. Remove the foil or wrapper from the suppository before inserting it.

  • To make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®).

  • Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.

  • Keep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

What to do if you miss a dose of Migergot

  • Store this medicine at room temperature, away from heat and direct light. Follow the directions on the medicine package label about storing the suppositories in the refrigerator, but do not freeze them.

  • Keep all medicine out of the reach of children and never share your medicine with anyone.

Migergot contraindications - Who shouldn't take Migergot?

  • You should not use this medicine if you have had an allergic reaction to ergotamine or caffeine, or if you are pregnant or plan to become pregnant. You should not use this medicine if you have high blood pressure, kidney disease, liver disease, heart disease, blood vessel disorders, or problems with circulation.

Migergot warnings

  • Make sure your doctor knows if you are breastfeeding, or if you have a stomach ulcer, glaucoma, or history of a stroke.

  • If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

  • Numbness or tingling in your fingers or toes

  • Pain or discomfort behind your breastbone

  • Pain, itching, or irritation around your rectum

  • Skin rash, swelling, or itching

  • Vomiting, numbness, tingling feeling, or pain and blue discoloration of your hands and feet

Migergot interactions & what to avoid when taking Migergot

  • Make sure your doctor knows if you are also using dopamine (Intropin®), sibutramine (Meridia®), antibiotics (such as Biaxin®, Dynabac®, Ery-Tab®), blood pressure medicine (such as atenolol, metoprolol, Inderal®, Toprol®), medicines to treat HIV/AIDS (Agenerase®, Crixivan®, Invirase®, Norvir®, Rescriptor®, Sustiva®, Viracept®), or other medicines to treat migraine headaches (Amerge®, Imitrex®, Maxalt®, Zomig„¢).

  • Do not drink alcohol while you are using this medicine. Avoid caffeine (coffee, tea, soft drinks, chocolate).

  • Smoking may make your headaches worse or increase the side effects of this medicine.

Migergot side effects - How does Migergot make you feel?

Serious Side Effects

  • Fast or slow heartbeat

  • Lightheadedness or fainting

  • Numbness or tingling in your fingers or toes

  • Pain or discomfort behind your breastbone

  • Pain, itching, or irritation around your rectum

  • Vomiting, numbness, tingling feeling, or pain and blue discoloration of your hands and feet

  • Skin rash, swelling, or itching

Less Serious Side Effects

  • Nervousness, irritability, dizziness

  • Nausea, vomiting, diarrhea, or stomach pain

  • Weakness in your legs

  • Muscle pain

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