Mili is a prescription combination birth control pill. 21 active tablets contain ethinyl estradiol and norgestimate to prevent pregnancy. Seven inert pills are taken at the end of the cycle to bring on withdrawal bleeding similar to a menstrual period. A low-estrogen triphasic version is available as Tri-Lo-Mili.
Mili
Norgestimate-ethinyl estradiol
Prevents pregnancy.
Oral contraceptive, monophasic contraceptive combination
Tablet
By mouth
Women of reproductive age use Mili to prevent pregnancy. Healthcare providers may prescribe it off-label for other conditions.
Tablet
0.25 mg norgestimate / 0.035 mg ethinyl estradiol
For the prevention of pregnancy: One tablet daily for 28 days
Mili
1 package (28 tablets), 0.25-35mg-mcg disp pack
Please read and follow the Instructions for Use that come with this medicine.
Take one pill daily at the same time each day. Do not miss doses.
There are 21 dark blue tablets containing active ingredients and seven inert green tablets. Take all the tablets in the blister pack, including the inert tablets.
Take the first tablet (number 1) on the day your period starts or the first Sunday after your period starts.
If you are taking Mili after using another form of birth control, take the first pill on the day you would have started a new blister pack, replaced a vaginal ring or patch, or the day an implant or IUD is removed.
Each tablet has a number assigned to it on the blister pack. Take each tablet in order.
Take tablets at the same time each day with or without food.
Swallow the tablet whole with a drink of water. Do not crush, break, or chew it.
When the last pill is taken, take the first dark blue pill in the next pack the next day.
Take the first pill of a new blister pack on the same day of the week each cycle.
If you vomit or have diarrhea three to four hours after taking a Mili tablet, take a dark blue pill from the extra blister pack.
If you don’t have an extra blister pack, take the next dark blue pill in the blister pack. Continue through the rest of the blister pack in order.
If you vomit or have diarrhea for more than one day. Use additional birth control measures until you contact the prescriber.
Store Mili at room temperature in the original carton.
Do not miss doses. Missed doses increase the risk of pregnancy.
If a dark blue pill is missed:
Take it when remembered. Take the next dose at its regular time.
You can take two doses in a single day to make up for the missed pill.
You are not at risk of getting pregnant and don’t need to use backup birth control.
If you miss two dark blue pills in a row in the first two weeks:
Take two pills on the day you remember and two pills the next day.
Missing two pills increases the risk of pregnancy. Use backup birth control for at least seven days.
If you miss two dark blue pills in a row in the third week:
You will have to start over with a new Mili blister pack if you are a Day 1 starter.
If you are a Sunday starter, continue to take the dark blue pills until Sunday. Start a new pack on Sunday.
You can get pregnant in the first seven days of starting a new kit. Use backup birth control.
If you miss three or more dark blue pills in a row in any week:
You will have to start over with a new Mili blister pack if you are a Day 1 starter.
If you are a Sunday starter, continue to take the dark blue pills until Sunday. Start a new pack on Sunday.
You can get pregnant for the first seven days after starting a new blister pack. Use backup birth control.
If you’re not sure about missing a dose, use backup birth control.
This medicine is not right for everyone.
Do not use Mili if you are:
Pregnant
Older than 35 and smoke
Older than 35 and have focal headaches or migraines with aura
Do not use Mili if you have:
Current or past blood clot problems
A history of stroke
Conditions that raise the risk of blood clots such as coronary artery disease, cerebrovascular disease, uncontrolled high blood pressure, certain types of heart valve problems, or diabetes with blood vessel disease
Uterine bleeding that has not been checked by a doctor
Liver disease or liver tumors
Current or past breast cancer that is hormone-sensitive
Tell any healthcare provider or other healthcare provider who treats you that you are using this medicine, especially before a medical or dental procedure. Oral contraceptives can skew the results of important blood tests.
Your doctor may need to do lab tests and check on your health. Keep all appointments.
Immediately inform the prescriber if you become pregnant, think you’re pregnant, or miss two periods in a row. A pregnancy test is needed.
Tell the prescriber if you:
Are pregnant
Think you’re pregnant
Miss two periods in a row
Have given birth within the last four weeks before starting Mili
Are breastfeeding
Smoke
Tell the prescriber if you have:
Heart problems
Circulation problems
High blood pressure
Diabetes
High cholesterol
Migraines
Depression
Allergic reactions that cause face, neck, and throat swelling (angioedema)
Tell the prescriber about any history of pregnancy problems, particularly:
Skin yellowing (jaundice) during pregnancy
Brown patches on your face (chloasma)
\Mili can cause serious side effects, including:
Increased risk of blood clots, heart attack, and stroke
Increased risk of breast or cervical cancer
Liver problems
Gallbladder problems
High blood pressure
High cholesterol
Severe or persistent headaches
Mili should not be used four weeks before or two weeks after major surgery.
Some women may experience skin discoloration when using Mili. Use sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases.
To avoid potentially hazardous drug interactions, give the prescribing clinician a complete list of the drugs and supplements you use, especially:
Barbiturates
Blood pressure drugs called calcium channel blockers
Antiviral drugs that treat hepatitis C or HIV/AIDS
Thyroid hormones
St. John’s wort
Aprepitant, atorvastatin, bosentan, colesevelam, cyclosporine, rifampicin, rosuvastatin, rufinamide
Avoid grapefruit and grapefruit juice when taking Mili.
Never take Mili or similar birth control pills along with any hepatitis C drug that contains ombitasvir/paritaprevir/ritonavir.
Tell other healthcare providers you are using this medicine before they prescribe new medications.
Serious side effects
Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:
Persistent leg pain, particularly in the calf
Sudden changes or loss of vision
Numbness or weakness on one side of your body, sudden or severe headache, vision, speech, or walking difficulties
Chest pain, chest tightness, trouble breathing, coughing up blood
Dark urine, clay-colored stools, loss of appetite, yellow skin or eyes
Breast tenderness, pain, swelling, lumps, or discharge
Stomach pain, nausea, vomiting
Depression
Allergic reaction: Rash, hives, itchiness, facial, mouth, tongue, or throat swelling, trouble breathing, wheezing
Some potentially serious side effects of Mili may not have symptoms. Patients will need regular check-ups and blood tests to monitor for these side effects:
High blood pressure
High cholesterol and fats
Less serious side effects
Headache
Abdominal pain
Breast tenderness
Vaginal discharge
Vaginal infection
Mood changes
Gas
Nervousness
Skin rash
Light spotting or bleeding between periods
Mili norgestimate and ethinyl estradiol kit prescribing information, DailyMed (NIH National Library of Medicine)
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