What is Naloxone: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Naloxone overview

BRAND NAMES:

  • PremierPro Rx naloxone HCl, Evzio, Naloxone HCl Novaplus

Generic Names:

  • Naloxone Hcl

Uses:

  • Treats narcotic overdose in an emergency situation.

Therapeutic Classes:

  • Antidote

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Naloxone used for?

What form(s) does Naloxone come in

  • Injectable

What are common Naloxone doses?

  • Vial 1ML of 0.4MG/ML

  • Vial 10ML of 4MG/10ML

  • Syringe 2ML of 2MG/2ML

  • Cartridge 1ML of 0.4MG/ML

  • Bottle 1GM of

  • Bottle 5GM of

Common Naloxone prescriptions

  • Naloxone HCl
    2 liquid box

  • Naloxone HCl
    1ml of 0.4mg/ml cartridge

  • Naloxone HCl
    2ml of 2mg/0.4ml pen

  • Naloxone HCl
    2ml of 2mg/2ml syringe

  • Naloxone HCl
    10ml of 4mg/10ml vial

  • Naloxone HCl
    1ml of 0.4mg/ml vial

How to take Naloxone

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • To use:Inject the medicine into the outer thigh, through clothing, if needed. If you are giving this medicine to a child younger than 1 year of age, pinch the thigh while you give the medicine.After you give the first dose to the patient, get emergency medical help right away.Closely watch the patient after the injection for signs and symptoms of an opioid emergency.Give a new injection every 2 to 3 minutes if symptoms return.

  • This medicine is available in 2 dosage strengths: 0.4 milligram (mg)/0.4 milliliter (mL) autoinjector and 2 mg/0.4mL autoinjector.

  • The autoinjector can be used only on time. Do not remove the red safety guard until you are ready to use it.

  • Do not use the medicine if it is cloudy, discolored, or has large particles in it.

  • This medicine comes with patient instructions and a training device. You, your home health caregiver, and family members should read the instructions carefully. Ask your doctor if you have any questions.

  • This medicine is given as a shot under your skin or into a muscle.

  • This medicine is given as a shot under your skin or into a muscle.

  • The autoinjector can be used only on time. Do not remove the red safety guard until you are ready to use it.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • To use:Inject the medicine into the outer thigh, through clothing, if needed. If you are giving this medicine to a child younger than 1 year of age, pinch the thigh while you give the medicine.After you give the first dose to the patient, get emergency medical help right away.Closely watch the patient after the injection for signs and symptoms of an opioid emergency.Give a new injection every 2 to 3 minutes if symptoms return.

  • Do not use the medicine if it is cloudy, discolored, or has large particles in it.

  • This medicine is available in 2 dosage strengths: 0.4 milligram (mg)/0.4 milliliter (mL) autoinjector and 2 mg/0.4mL autoinjector.

  • This medicine comes with patient instructions and a training device. You, your home health caregiver, and family members should read the instructions carefully. Ask your doctor if you have any questions.

What to do if you miss a dose of Naloxone

Naloxone contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to naloxone.

Naloxone warnings

  • Diarrhea, nausea, vomiting, stomach cramps

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or heart disease.

  • Fast, pounding, or uneven heartbeat, trouble breathing

  • Fever, runny nose, sneezing, sweating, yawning

  • Seizures, tremors, feeling restless, nervous, or irritable

Naloxone interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney, liver, or heart disease.

Naloxone side effects

Serious Side Effects

  • Fast, pounding, or uneven heartbeat, trouble breathing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Seizures, tremors, feeling restless, nervous, or irritable

  • Diarrhea, nausea, vomiting, stomach cramps

  • Crying more than the usual (in babies)

  • Fever, runny nose, sneezing, sweating, yawning

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.