Trintellix Coupons & Prices

Trintellix (vortioxetine) is a serotonin modulator antidepressant that works by balancing serotonin levels in the brain. Serotonin is an important neurotransmitter (chemical messenger) that plays a role in mood, sleep, and appetite. Trintellix is approved to treat major depressive disorder and is only available as a brand-name drug at this time. The average retail price of Trintellix is $677.35 for 30, 20mg tablets. If you are underinsured or uninsured, Trintellix may be an expensive prescription medicine. However, you could pay $465.93 for 30, 20mg tablets for your next prescription or refill by using a Trintellix coupon from SingleCare’s discount program.

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Trintellix coupon at Kroger Pharmacy
$468.93
$ 465.93
$3 off with signupwith signup

Show this free card to your pharmacist.

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Trintellix coupon at Harris Teeter Pharmacy
$468.93
$ 465.93
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

Members can save even more
and it's free to join

Trintellix coupon at Walgreens Pharmacy
$475.42
$ 472.42
$3 off with signupwith signup
Trintellix coupon at Walmart Neighborhood Market Pharmacy
$481.00
$ 478.00
$3 off with signupwith signup
Trintellix coupon at Walmart Pharmacy
$481.00
$ 478.00
$3 off with signupwith signup
Trintellix coupon at Publix Pharmacy
$482.60
$ 479.60
$3 off with signupwith signup
$485.77
$ 482.77
$3 off with signupwith signup
$486.49
$ 483.49
$3 off with signupwith signup
$ 532.43

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Trintellix

Trintellix (vortioxetine) is a serotonin modulator antidepressant that works by balancing serotonin levels in the brain. Serotonin is an important neurotransmitter (chemical messenger) that plays a role in mood, sleep, and appetite. Trintellix is approved to treat major depressive disorder and is only available as a brand-name drug at this time. The average retail price of Trintellix is $677.35 for 30, 20mg tablets. If you are underinsured or uninsured, Trintellix may be an expensive prescription medicine. However, you could pay $465.93 for 30, 20mg tablets for your next prescription or refill by using a Trintellix coupon from SingleCare’s discount program.

Trintellix Price History & Information

Price History for Trintellix

30 count, tablet, 20mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Trintellix

30 count, tablet, 20mg
PharmacyTrintellix Retail PriceTrintellix SingleCare Price
CVS Pharmacy$611.10$463.50
Walmart$617.10$480.90
Walgreens$564.90$546.90
Kroger Pharmacy$617.10$468.90
Albertsons Pharmacy$575.70$483.60

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Trintellix

Trintellix (vortioxetine) is a serotonin modulator antidepressant that works by balancing serotonin levels in the brain. Serotonin is an important neurotransmitter (chemical messenger) that plays a role in mood, sleep, and appetite. Trintellix is approved to treat major depressive disorder and is only available as a brand-name drug at this time. The average retail price of Trintellix is $677.35 for 30, 20mg tablets. If you are underinsured or uninsured, Trintellix may be an expensive prescription medicine. However, you could pay $465.93 for 30, 20mg tablets for your next prescription or refill by using a Trintellix coupon from SingleCare’s discount program.

Trintellix FAQs

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist

How much is Trintellix with SingleCare?

The generic of Trintellix costs $465.93 for 30, 20mg tablets with a free Trintellix coupon from SingleCare. You could pay less depending on your Rx information. Use the dropdown menu above to enter your Rx info (i.e., brand/generic, quantity, form, dosage) to find the most accurate price of Trintellix with SingleCare at your local pharmacies.

How much does Trintellix cost without insurance?

Without insurance, Trintellix costs an average price of $677.35 for 30, 20mg tablets. The cost of Trintellix will depend on different factors, such as the pharmacy you use and the quantity prescribed. You may have to check with different pharmacies to find the best price. If you don’t have insurance or if your copay is too high with insurance, you can get a free SingleCare card that could lower the price to $465.93 for 30, 20mg tablets for Trintellix. People without insurance can also check into the manufacturer’s patient assistance program, which is based on financial need and has certain eligibility requirements.

How much does Trintellix cost with insurance?

The cost of Trintellix with health insurance depends on the plan you’re enrolled in. You can check with your insurance company or pharmacy to determine your copay with insurance. Trintellix is a brand-name drug that is usually placed on higher tiers of drug formularies. In other words, you may have to pay more for Trintellix than other low-cost alternatives with insurance. Instead, you may be able to get a better deal by using a SingleCare card. With SingleCare, you could pay as little as $465.93 for 30, 20mg tablets of Trintellix. You can ask the pharmacy to run your SingleCare coupon and compare prices before you pay for your Trintellix prescription. You can use the SingleCare discount for savings at any participating pharmacy in the United States—no personal information or signup is required.

Does Medicare cover Trintellix?

Trintellix is generally covered by Medicare Part D plans or Medicare Advantage plans. Check with your prescription drug plan to determine your copay or coinsurance amount for Trintellix. The cost of Trintellix with Medicare can vary depending on the plan and your insurance coverage. If you don’t have enough coverage with Medicare, you may be able to save more by using a SingleCard coupon instead. Use SingleCare's search tool to find the pharmacy with the best price.

Does Medicaid cover Trintellix?

Medicaid may cover the cost of Trintellix, depending on the plan and state. Medicaid copays usually range from $0 to $8 when a medication is covered. Prior authorization may also be needed before covering Trintellix. Some plans may only cover alternative antidepressant medications instead. If Trintellix is not covered, consider using a SingleCare coupon to pay as little as $465.93 for 30, 20mg tablets.

Is there a generic of Trintellix?

Trintellix is a brand-name drug. Trintellix was originally named Brintellix, but the FDA approved its name change to avoid confusion with Brilinta, an antiplatelet drug. The active ingredient of Trintellix is vortioxetine, but a generic version is not yet available. 

Ways to save on Trintellix

If Trintellix is still too expensive, use a free SingleCare savings card to pay as little as $465.93 for 30, 20mg tablets. Signing up for SingleCare’s loyalty program can help you save even more each month. 

There are other potential ways to save on Trintellix, such as:

  • Asking your healthcare provider for free samples, although this is not a long-term solution to reduce savings

  • Using a manufacturer coupon to pay as little as $10 per 30 or 90 days if eligible (only with commercial insurance that is not funded by the government)

  • Enrolling in patient assistance programs, depending on eligibility

  • Shopping around to see the cost of Trintellix at different pharmacies

  • Applying for Medicare Extra Help if eligible

  • Using a flexible spending account (FSA) or health savings account (HSA) if available

  • Switching to an alternative medication

Is there a cheaper alternative to Trintellix?

Cheaper alternatives to Trintellix may be available based on your insurance’s formulary. Viibryd (vilazodone) is another serotonin modulator that is now available as a generic medication. Other atypical antidepressants include Wellbutrin (bupropion) and Remeron (mirtazapine), which may also be cheaper than Trintellix because generic versions of them are available. Talk to your healthcare provider about all available options and the best treatment plan for you.

How to use SingleCare for Trintellix

SingleCare coupons are accepted at most national pharmacies and grocers, such as Walgreens, Kroger, Walmart, CVS, Safeway, and more. Just text, email, print, or save your free Trintellix coupon to your digital wallet and show a pharmacist at checkout. 

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist

Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.

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Where are Trintellix coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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