Trintellix (vortioxetine) is a serotonin modulator antidepressant that works by balancing serotonin levels in the brain. Serotonin is an important neurotransmitter (chemical messenger) that plays a role in mood, sleep, and appetite. Trintellix is approved to treat major depressive disorder and is only available as a brand-name drug at this time. The average retail price of Trintellix is $677.35 for 30, 20mg tablets. If you are underinsured or uninsured, Trintellix may be an expensive prescription medicine. However, you could pay $465.93 for 30, 20mg tablets for your next prescription or refill by using a Trintellix coupon from SingleCare’s discount program.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Trintellix (vortioxetine) is a serotonin modulator antidepressant that works by balancing serotonin levels in the brain. Serotonin is an important neurotransmitter (chemical messenger) that plays a role in mood, sleep, and appetite. Trintellix is approved to treat major depressive disorder and is only available as a brand-name drug at this time. The average retail price of Trintellix is $677.35 for 30, 20mg tablets. If you are underinsured or uninsured, Trintellix may be an expensive prescription medicine. However, you could pay $465.93 for 30, 20mg tablets for your next prescription or refill by using a Trintellix coupon from SingleCare’s discount program.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Trintellix Retail Price | Trintellix SingleCare Price |
|---|---|---|
| CVS Pharmacy | $611.10 | $463.50 |
| Walmart | $617.10 | $480.90 |
| Walgreens | $564.90 | $546.90 |
| Kroger Pharmacy | $617.10 | $468.90 |
| Albertsons Pharmacy | $575.70 | $483.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Trintellix (vortioxetine) is a serotonin modulator antidepressant that works by balancing serotonin levels in the brain. Serotonin is an important neurotransmitter (chemical messenger) that plays a role in mood, sleep, and appetite. Trintellix is approved to treat major depressive disorder and is only available as a brand-name drug at this time. The average retail price of Trintellix is $677.35 for 30, 20mg tablets. If you are underinsured or uninsured, Trintellix may be an expensive prescription medicine. However, you could pay $465.93 for 30, 20mg tablets for your next prescription or refill by using a Trintellix coupon from SingleCare’s discount program.
The generic of Trintellix costs $465.93 for 30, 20mg tablets with a free Trintellix coupon from SingleCare. You could pay less depending on your Rx information. Use the dropdown menu above to enter your Rx info (i.e., brand/generic, quantity, form, dosage) to find the most accurate price of Trintellix with SingleCare at your local pharmacies.
Without insurance, Trintellix costs an average price of $677.35 for 30, 20mg tablets. The cost of Trintellix will depend on different factors, such as the pharmacy you use and the quantity prescribed. You may have to check with different pharmacies to find the best price. If you don’t have insurance or if your copay is too high with insurance, you can get a free SingleCare card that could lower the price to $465.93 for 30, 20mg tablets for Trintellix. People without insurance can also check into the manufacturer’s patient assistance program, which is based on financial need and has certain eligibility requirements.
The cost of Trintellix with health insurance depends on the plan you’re enrolled in. You can check with your insurance company or pharmacy to determine your copay with insurance. Trintellix is a brand-name drug that is usually placed on higher tiers of drug formularies. In other words, you may have to pay more for Trintellix than other low-cost alternatives with insurance. Instead, you may be able to get a better deal by using a SingleCare card. With SingleCare, you could pay as little as $465.93 for 30, 20mg tablets of Trintellix. You can ask the pharmacy to run your SingleCare coupon and compare prices before you pay for your Trintellix prescription. You can use the SingleCare discount for savings at any participating pharmacy in the United States—no personal information or signup is required.
Trintellix is generally covered by Medicare Part D plans or Medicare Advantage plans. Check with your prescription drug plan to determine your copay or coinsurance amount for Trintellix. The cost of Trintellix with Medicare can vary depending on the plan and your insurance coverage. If you don’t have enough coverage with Medicare, you may be able to save more by using a SingleCard coupon instead. Use SingleCare's search tool to find the pharmacy with the best price.
Medicaid may cover the cost of Trintellix, depending on the plan and state. Medicaid copays usually range from $0 to $8 when a medication is covered. Prior authorization may also be needed before covering Trintellix. Some plans may only cover alternative antidepressant medications instead. If Trintellix is not covered, consider using a SingleCare coupon to pay as little as $465.93 for 30, 20mg tablets.
Trintellix is a brand-name drug. Trintellix was originally named Brintellix, but the FDA approved its name change to avoid confusion with Brilinta, an antiplatelet drug. The active ingredient of Trintellix is vortioxetine, but a generic version is not yet available.
If Trintellix is still too expensive, use a free SingleCare savings card to pay as little as $465.93 for 30, 20mg tablets. Signing up for SingleCare’s loyalty program can help you save even more each month.
There are other potential ways to save on Trintellix, such as:
Asking your healthcare provider for free samples, although this is not a long-term solution to reduce savings
Using a manufacturer coupon to pay as little as $10 per 30 or 90 days if eligible (only with commercial insurance that is not funded by the government)
Enrolling in patient assistance programs, depending on eligibility
Shopping around to see the cost of Trintellix at different pharmacies
Applying for Medicare Extra Help if eligible
Using a flexible spending account (FSA) or health savings account (HSA) if available
Switching to an alternative medication
Cheaper alternatives to Trintellix may be available based on your insurance’s formulary. Viibryd (vilazodone) is another serotonin modulator that is now available as a generic medication. Other atypical antidepressants include Wellbutrin (bupropion) and Remeron (mirtazapine), which may also be cheaper than Trintellix because generic versions of them are available. Talk to your healthcare provider about all available options and the best treatment plan for you.
SingleCare coupons are accepted at most national pharmacies and grocers, such as Walgreens, Kroger, Walmart, CVS, Safeway, and more. Just text, email, print, or save your free Trintellix coupon to your digital wallet and show a pharmacist at checkout.
Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved