Neostigmine Methylsulfate is a generic prescription drug used to control symptoms of myasthenia gravis (a muscle weakness condition), prevent swelling and urinary retention after surgery, and reverse the effects of muscle relaxants used in surgery. Neostigmine Methylsulfate is administered by healthcare professionals in a hospital or clinic and is not available for purchase at consumer pharmacies. Neostigmine Methylsulfate normally retails for $539.88, but SingleCare offers a free Neostigmine Methylsulfate coupon that lowers Neostigmine Methylsulfate's cost to $176.75 if the hospital or clinic that administers Neostigmine Methylsulfate accepts SingleCare discount cards.
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Prices updated: 12/05/2025
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Neostigmine Methylsulfate is a generic prescription drug used to control symptoms of myasthenia gravis (a muscle weakness condition), prevent swelling and urinary retention after surgery, and reverse the effects of muscle relaxants used in surgery. Neostigmine Methylsulfate is administered by healthcare professionals in a hospital or clinic and is not available for purchase at consumer pharmacies. Neostigmine Methylsulfate normally retails for $539.88, but SingleCare offers a free Neostigmine Methylsulfate coupon that lowers Neostigmine Methylsulfate's cost to $176.75 if the hospital or clinic that administers Neostigmine Methylsulfate accepts SingleCare discount cards.
Neostigmine Methylsulfate is a generic prescription drug used to control symptoms of myasthenia gravis (a muscle weakness condition), prevent swelling and urinary retention after surgery, and reverse the effects of muscle relaxants used in surgery. Neostigmine Methylsulfate is administered by healthcare professionals in a hospital or clinic and is not available for purchase at consumer pharmacies. Neostigmine Methylsulfate normally retails for $539.88, but SingleCare offers a free Neostigmine Methylsulfate coupon that lowers Neostigmine Methylsulfate's cost to $176.75 if the hospital or clinic that administers Neostigmine Methylsulfate accepts SingleCare discount cards.
Neostigmine Methylsulfate is not sold at consumer pharmacies or purchased by patients. It is purchased by hospitals or clinics from specialty pharmacies and administered by a healthcare professional.
The retail price of Neostigmine Methylsulfate without insurance averages $539.88. If the clinic or hospital accepts a SingleCare discount card, you pay only $176.75 for that same Neostigmine Methylsulfate prescription.
Copay costs of Neostigmine Methylsulfate vary depending on your insurance plan. When used as part of a procedure, the cost of Neostigmine Methylsulfate may be reimbursed as a medical benefit and included with the copay cost for the procedure.
With SingleCare, Neostigmine Methylsulfate costs as little as $176.75 for 25, 10ml of 10mg/10ml vials. Ask your hospital or clinical case manager if they accept a SingleCare Neostigmine Methylsulfate coupon.
Medicare prescription drug plans do not cover Neostigmine Methylsulfate, but it is covered under Medicare Part B as part of covered procedures. SingleCare offers discount coupons for Neostigmine Methylsulfate which may reduce the cost of a Neostigmine Methylsulfate injection to $176.75. Ask your hospital's case manager or your clinical case manager about the eligibility of a SingleCare Neostigmine Methylsulfate coupon.
Neostigmine Methylsulfate is a generic prescription drug manufactured by Dr. Reddy's, Par, Amneal, and other generic manufacturers. Neostigmine Methylsulfate is the active ingredient in Prostigmin. Find Prostigmin on the SingleCare website or app if you need more information or savings coupons.
Neostigmine Methylsulfate is a generic prescription drug used to control symptoms of myasthenia gravis (a muscle weakness condition), prevent swelling and urinary retention after surgery, and reverse the effects of muscle relaxants used in surgery.
All of these conditions are due to nerves losing the ability to stimulate muscle contractions. Neostigmine Methylsulfate prevents an enzyme, called acetylcholinesterase, from breaking down a chemical, called acetylcholine, that is responsible for passing nerve signals to muscles to signal them to contract.
Myasthenia gravis is a rare condition in which the number of acetylcholine receptors in muscles declines. As a result, muscles receive “weaker” signals from the brain, resulting in overall muscle weakness. By preventing acetylcholine from being broken down, Neostigmine Methylsulfate allows the acetylcholine to linger at the remaining muscle receptors longer. More of the nerve signals are sent to the muscle, allowing greater movement and strength.
Muscle relaxants are given in surgery target these same receptors by increasing the activity of acetylcholinesterase, the enzyme that breaks down acetylcholine. Neostigmine Methylsulfate quickly reverses that effect, allowing patients to start moving muscles after surgery.
Neostigmine Methylsulfate is administered as an intravenous or intramuscular injection by a healthcare professional.
Many of the side effects are due to increased muscle sensitivity to nerve signals, especially in nerves that control involuntary muscles, like sweat glands. These side effects are very common and include increased sweating, increased salivation, increased mucus, decreased pupil size, increased urination, stomach and intestinal cramps, muscle cramps, and muscle twitching.
Other common side effects include nausea, vomiting, fainting, and drowsiness.
The most serious side effects of Neostigmine Methylsulfate are very rare but include slow heartbeat, cardiovascular complications, and convulsions.
Allergic reactions are possible and could be severe, including anaphylaxis, a dangerous drop in blood pressure.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved