What is Norpace: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Norpace overview

BRAND NAMES:

  • Norpace, Norpace CR

Generic Names:

  • Disopyramide Phosphate

Uses:

  • Treats irregular heartbeat (arrhythmias). Belongs to a class of drugs called antiarrhythmics.

Therapeutic Classes:

  • Antiarrhythmic, Group IA

Forms:

  • Capsule, Long Acting Tablet, Long Acting Capsule

How it’s taken:

  • By mouth

What is Norpace used for?

Norpace is an antiarrhythmic drug that works by blocking certain electrical signals in the heart that can cause an irregular heartbeat. It is used to treat serious irregular heartbeat patterns, such as persistent ventricular tachycardia.

What form(s) does Norpace come in

  • Capsule

  • Long Acting Tablet

  • Long Acting Capsule

What are common Norpace doses?

  • Capsule 100MG

  • Capsule 150MG

Common Norpace prescriptions

  • Norpace
    100mg capsule

  • Norpace
    150mg capsule

How to take Norpace

  • Your doctor will tell you how much to take and how often.

  • Take this medicine exactly as your doctor ordered, even if you feel fine.

  • May be taken with food or milk to avoid stomach upset.

  • Swallow the extended-release tablet or extended-release capsule whole - do not break, chew, or crush.

  • You may need to carry identification that says you are taking disopyramide. Ask you doctor about this.

  • You may need to carry identification that says you are taking disopyramide. Ask you doctor about this.

  • Your doctor will tell you how much to take and how often.

  • Take this medicine exactly as your doctor ordered, even if you feel fine.

  • May be taken with food or milk to avoid stomach upset.

  • Swallow the extended-release tablet or extended-release capsule whole - do not break, chew, or crush.

What to do if you miss a dose of Norpace

  • You should not use two doses at the same time.

  • Take the missed dose as soon as possible unless your next regular dose is less than 4 hours away.

  • If it is less than 4 hours until your next dose, wait until then to take your medicine and skip the missed.

Norpace contraindications

  • You should not use this medicine if you have had an allergic reaction to disopyramide in the past.

Norpace warnings

  • Check with your doctor before taking if you have kidney or liver disease, glaucoma, an enlarged prostate, trouble urinating, diabetes, or myasthenia gravis.

  • Tell your doctor or dentist that you are taking disopyramide before having any kind of surgery.

  • Do not suddenly stop taking this medicine without asking your doctor.

  • Talk with your doctor before taking this medicine if you are pregnant or breastfeeding.

  • While taking this medicine, avoid becoming overheated during hot weather or exercising.

  • Standing-up slowly from a sitting or lying position can lessen the chance of getting dizzy.

  • Disopyramide may make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

  • Swelling of the legs and feet or weight gain

  • Yellowing of skin or eyes

Norpace interactions

  • Tell your doctor if you are taking any of these medicines: other heart medicines such as Procan®, Quinidex®, Lanoxin®, Cordarone®, or Inderal®, phenytoin (Dilantin®), or pimozide (Orap®).

  • Avoid drinking alcohol while taking this medicine.

  • Do not suddenly stop taking this medicine without asking your doctor.

  • Talk with your doctor before taking this medicine if you are pregnant or breastfeeding.

  • While taking this medicine, avoid becoming overheated during hot weather or exercising.

  • Standing-up slowly from a sitting or lying position can lessen the chance of getting dizzy.

  • Disopyramide may make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

Norpace side effects

Serious Side Effects

  • Irregular heartbeat

  • Chest pain

  • Shortness of breath or trouble breathing

  • Blurred vision

  • Trouble urinating

  • Fever, chills, or sore throat

  • Skin rash, severe itching or hives

  • Swelling of the legs and feet or weight gain

  • Yellowing of skin or eyes

Less Serious Side Effects

  • Headache, nervousness, or confusion

  • Decreased sexual ability or interest

  • Nausea or vomiting

  • Stomach cramps or loss of appetite

  • Dry mouth or throat

  • Trembling or shaking

  • Dizziness, lightheadedness, fainting

  • Tiredness or weakness

  • Constipation, bloating, gas

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