Xiidra Coupons & Prices

Xiidra is a prescription eyedrop medication used to treat dry eye syndrome, also known as dry eye disease (DED). Xiidra is a brand-name drug that contains the active ingredient lifitegrast. It may help treat symptoms of dry eyes, such as eye irritation and inflammation. The average retail price of Xiidra is $998.87 for 60, 5% Solution. However, with a SingleCare Xiidra coupon, you could pay as low as $586.87 for 60 single-use containers of 5% Solution at participating pharmacies.

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Xiidra coupon at Kroger Pharmacy
$589.87
$ 586.87
  • How is this calculated?

  • Price if you don’t sign up:

    $589.87

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $586.87

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup
Xiidra coupon at Harris Teeter Pharmacy
$589.87
$ 586.87
  • How is this calculated?

  • Price if you don’t sign up:

    $589.87

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $586.87

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

Members can save even more
and it's free to join

Xiidra coupon at Walgreens Pharmacy
$615.51
$ 612.51
  • How is this calculated?

  • Price if you don’t sign up:

    $615.51

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $612.51

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup
Xiidra coupon at Rite Aid Pharmacy
$630.76
$ 627.76
  • How is this calculated?

  • Price if you don’t sign up:

    $630.76

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $627.76

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup
Xiidra coupon at Cvs Pharmacy
$656.89
$ 653.89
  • How is this calculated?

  • Price if you don’t sign up:

    $656.89

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $653.89

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup
Xiidra coupon at Walmart Neighborhood Market Pharmacy
$665.15
$ 662.15
  • How is this calculated?

  • Price if you don’t sign up:

    $665.15

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $662.15

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup
$665.15
$ 662.15
  • How is this calculated?

  • Price if you don’t sign up:

    $665.15

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $662.15

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup
$670.35
$ 667.35
  • How is this calculated?

  • Price if you don’t sign up:

    $670.35

  • One-time signup bonus

    -$3.00

  • Price with free signup

    $667.35

  • Signup bonus and member savings are automatically applied to your price when you fill an eligible prescription.

  • Sign up for free
Price with signup$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

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About Xiidra

Xiidra is a prescription eyedrop medication used to treat dry eye syndrome, also known as dry eye disease (DED). Xiidra is a brand-name drug that contains the active ingredient lifitegrast. It may help treat symptoms of dry eyes, such as eye irritation and inflammation. The average retail price of Xiidra is $998.87 for 60, 5% Solution. However, with a SingleCare Xiidra coupon, you could pay as low as $586.87 for 60 single-use containers of 5% Solution at participating pharmacies.

Xiidra Price History & Information

Price History for Xiidra

60 count, 5%

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 12 Month Prices for Xiidra

60 count, 5%
PharmacyXiidra Retail PriceXiidra SingleCare Price
CVS Pharmacy$830.42$677.14
Walmart$813.11$660.46
Walgreens$933.40$730.70
Kroger Pharmacy$839.83$602.16
Albertsons Pharmacy$787.56$669.14
Rite Aid Pharmacy$920.73$628.47

These prices are based on the last 12 months of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Xiidra

Xiidra is a prescription eyedrop medication used to treat dry eye syndrome, also known as dry eye disease (DED). Xiidra is a brand-name drug that contains the active ingredient lifitegrast. It may help treat symptoms of dry eyes, such as eye irritation and inflammation. The average retail price of Xiidra is $998.87 for 60, 5% Solution. However, with a SingleCare Xiidra coupon, you could pay as low as $586.87 for 60 single-use containers of 5% Solution at participating pharmacies.

Xiidra FAQs

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

How much does Xiidra cost without insurance?

The average retail price of a 30-day prescription of Xiidra without insurance is $998.87 for 60, 5% Solution. However, the price without insurance can vary depending on the pharmacy and location. You may be able to use a free SingleCare savings card and pay a discounted price of $586.87 for 60, 5% Solution on your next Xiidra prescription.

How much does Xiidra cost with insurance?

The cost of Xiidra with health insurance may vary by insurance plan. Check with your pharmacist to determine your copay cost with your insurance when you order your Xiidra refill. You can also consult your insurance provider directly for details. You may want to compare prices between your insurance coverage and SingleCare to ensure you're receiving the best deal. The price with SingleCare may work out to be cheaper than what your insurance company charges you. 

Does Medicare cover Xiidra and how much does it cost?

Medicare prescription plans may or may not cover Xiidra. The average copay for Xiidra with Medicare will vary by plan, prescription, and coverage stage. Check your Medicare Part D or Medicare Advantage plan's drug formulary to confirm coverage. You can also use a SingleCare discount card at a participating pharmacy to get a discount on your prescription. SingleCare’s lowest price for Xiidra is currently $586.87 for 60, 5% Solution.

How to save on Xiidra

Xiidra manufacturer coupons and patient assistance programs may be available to eligible patients to save. If you’re looking to save money on Xiidra, you can also use a Xiidra coupon from SingleCare. 

With SingleCare, there are no other eligibility requirements, such as an application or membership fee. It can be used at participating pharmacies across the United States and Puerto Rico, with no limitations on how often it can be used. 

Is there a generic of Xiidra?

Xiidra is a brand-name prescription drug manufactured by Novartis Pharmaceuticals Corporation. Lifitegrast is the active ingredient and generic name of Xiidra. While a generic version may be approved, there may not be an equivalent generic substitute of Xiidra available at this time.

What is Xiidra?

Xiidra is an FDA-approved eye drop medication used to treat the symptoms of dry eye disease, sometimes referred to as dry eye syndrome. It works by blocking certain proteins that can cause your eyes to not produce enough tears, resulting in dry eyes, irritation, and inflammation.

What class of drug is Xiidra? 

Xiidra is in a drug class called lymphocyte function-associated antigen-1 (LFA-1) antagonists. 

What doses of Xiidra are available?

Xiidra is available in 60, 5% Solution, each containing a 5% ophthalmic solution. It should only be used as directed by a doctor or healthcare professional. The typical dosage is one drop in each eye twice daily, with at least 12 hours between each dose. 

What are the side effects of Xiidra?

Common side effects of Xiidra may include eye irritation, discomfort, blurred vision, and a temporary change in taste sensation. These side effects are generally mild and go away on their own. Other side effects may include redness or itching of the eyes and headaches. 

Serious side effects are rare, but if you experience symptoms of a serious allergic reaction, such as hives, trouble breathing, or swelling of the face, lips, tongue, or throat, get emergency medical help. You should also seek medical care if you experience side effects that persist or worsen. Consult a healthcare provider about other possible side effects, as this is not a complete list of adverse events.

Does Xiidra interact with other medications?

Before taking Xiidra, tell your healthcare provider about all your medications, including prescription and over-the-counter medicines, vitamins, and supplements. Xiidra is not known to have any significant drug interactions.

How do I use Xiidra?

Instill one drop in each eye twice daily, about 12 hours apart, using the single-use container. Discard the container after using it in each eye. Remove contact lenses before using Xiidra and wait 15 minutes to put them back in after you put in your eye drops.

Who should not use Xiidra?

Xiidra should not be used in anyone allergic to lifitegrast or any inactive components of the medication.

Is there an alternative to Xiidra?

If Xiidra is not suitable for you, your healthcare provider may recommend alternative treatments for dry eye disease. Other prescription medications used for dry eye disease include Restasis (cyclosporine), Cequa (cyclosporine), and Eysuvis (loteprednol). Various over-the-counter products can help relieve symptoms of dry eyes, such as Artificial Tears or Systane. Consult your healthcare provider for professional medical advice and more information on dry eye treatment.

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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