What is Northera? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Northera overview

BRAND NAMES:

  • Northera

Generic Names:

  • Northera

Uses:

  • Treats lightheadedness, dizziness, or fainting.

Therapeutic Classes:

  • Vasopressor

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Northera used for?

Northera is used to treat low blood pressure caused by a certain medical condition called neurogenic orthostatic hypotension-NOH. Northera works by narrowing the blood vessels and increasing blood pressure.

What form(s) does Northera come in?

  • Capsule

What are common Northera dosages?

  • Capsule 100MG

  • Capsule 200MG

  • Capsule 300MG

Northera images - What does Northera look like?

  • Northera
    100mg capsule

  • Northera
    200mg capsule

  • Northera
    300mg capsule

How to take Northera

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Your doctor may tell you to take this medicine after you wake up in the morning, at noon, and in the late afternoon at least 3 hours before bedtime.

  • You may choose to take this medicine with food or without food, but it is important that you take it the same way each time.

  • Swallow the capsule whole. Do not crush, break, or chew it.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the capsule whole. Do not crush, break, or chew it.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Your doctor may tell you to take this medicine after you wake up in the morning, at noon, and in the late afternoon at least 3 hours before bedtime.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • You may choose to take this medicine with food or without food, but it is important that you take it the same way each time.

What to do if you miss a dose of Northera

Northera contraindications - Who shouldn't take Northera?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to droxidopa.

Northera warnings

  • Tell your doctor if you are pregnant or if you have kidney disease, asthma, congestive heart failure, heart or blood vessel problems, heart rhythm problems, or have an allergy to aspirin.

  • Do not breastfeed while you are using this medicine.

  • This medicine may raise your blood pressure and increase your risk for supine hypertension (high blood pressure when you lie on your back). It is best to elevate the head of your bed, and to rest and sleep with your head elevated. You may also need to monitor your blood pressure at home before, during, and after treatment.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Northera interactions & what to avoid when taking Northera

  • Some medicines can affect how droxidopa works. Tell your doctor if you are using any of the following:Ephedrine, levodopa, midodrineMAO inhibitor (MAOI)Medicine to treat migraine headaches (including eletriptan, frovatriptan, rizatriptan, sumatriptan, zolmitriptan)

  • This medicine may raise your blood pressure and increase your risk for supine hypertension (high blood pressure when you lie on your back). It is best to elevate the head of your bed, and to rest and sleep with your head elevated. You may also need to monitor your blood pressure at home before, during, and after treatment.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Northera side effects - How does Northera make you feel?

Serious Side Effects

  • Confusion or fever

  • Fast, pounding, or uneven heartbeat

  • Swelling in your hands, ankles, or feet

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blurred vision, severe headache, trouble breathing

Less Serious Side Effects

  • Headache

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.