What is Oncaspar? Uses, warnings & side effects

Updated May 14, 2025  •  Published Sep 30, 2021

Oncaspar overview

BRAND NAMES:

  • Oncaspar

Generic Names:

  • Oncaspar

Uses:

  • Treats acute lymphoblastic leukemia (ALL) and in patients with serious allergic reactions from previous treatment with L-asparaginase.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Oncaspar used for?

What form(s) does Oncaspar come in?

  • Injectable

What are common Oncaspar dosages?

  • Vial 5ML of 750UNIT/ML

Oncaspar images - What does Oncaspar look like?

  • Oncaspar
    5ml of 750unit/ml vial

How to take Oncaspar

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or through a needle place into one of your veins.

  • Injection route: You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

What to do if you miss a dose of Oncaspar

  • Injection route: Call your doctor or pharmacist for instructions.

Oncaspar contraindications - Who shouldn't take Oncaspar?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to pegaspargase, or if you have severe liver disease or a history of blood clots, pancreatitis (swelling of the pancreas), or bleeding problems caused by a previous L-asparaginase treatment.

Oncaspar warnings

  • Injection route: It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (including condoms or spermicide) along with your pills during treatment and for at least 3 months after the last dose.

  • Do not breastfeed during treatment with this medicine and for 3 months after the last dose.

  • Tell your doctor if you have diabetes.

  • This medicine may cause the following problems: Blood clotsPancreatitis, which may be life-threatening, increased risk of glucose intolerance, including high blood sugar,liver problems

  • This medicine may increase your risk of bleeding. Talk to your doctor about any unusual bleeding or bruising. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.

  • Injection route: Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Sudden and severe stomach pain, nausea, vomiting, or lightheadedness.

  • Sudden or severe headache, problems with vision, speech, or walking.

  • Swelling of the arm or leg.

  • Unexplained fever or chills.

  • Unusual bleeding, bruising, or weakness.

  • Yellowing of your skin or the whites of your eyes.

Oncaspar interactions & what to avoid when taking Oncaspar

  • Make sure your doctor knows if you are taking any medicine that affects blood clotting, such as aspirin or warfarin (Coumadin®).

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

  • Some people who have used this medicine developed serious allergic reactions while receiving this medicine. Your doctor will need you to stay at the clinic or hospital for at least one hour after receiving this medicine to check you for any unwanted effects that may be caused by this medicine.

  • This medicine may cause problems with your blood sugar. Check with your doctor if you experience increased thirst or hunger, or any increase in how much or how often you urinate.

  • This medicine may increase your risk of developing serious blood clots. Tell your doctor right away if you develop any sudden or severe headaches, arm or leg swelling, shortness of breath, or chest pain.

  • Check with your doctor right away if you start having severe stomach pain, nausea, vomiting, fever, or lightheadedness. You may be having problems with your pancreas.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Oncaspar side effects - How does Oncaspar make you feel?

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, trouble breathing, coughing up blood

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Increased hunger, thirst, or how much or how often you urinate

  • Numbness or weakness in your arm or leg, or on one side of your body

  • Pain in your lower leg (calf)

  • Sudden and severe stomach pain, lightheadedness

  • Sudden or severe headache, problems with vision, speech, or walking

  • Unusual bleeding, bruising, or weakness

  • Swelling of the arm or leg.

  • Unexplained fever or chills.

  • Unusual bleeding, bruising, or weakness.

  • Yellowing of your skin or the whites of your eyes.

Less Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle was placed or shot given

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