What is Ongentys: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Ongentys overview

BRAND NAMES:

  • Ongentys

Generic Names:

  • Ongentys

Uses:

  • Treats "off" episodes in patients with Parkinson disease.

Therapeutic Classes:

  • Antiparkinsonian

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Ongentys used for?

What form(s) does Ongentys come in

  • Capsule

What are common Ongentys doses?

  • Capsule 50MG

Common Ongentys prescriptions

  • Ongentys
    25mg capsule

  • Ongentys
    50mg capsule

How to take Ongentys

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: Skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeIt is best to take this medicine on an empty stomach. Take this medicine at bedtime. Do not eat 1 hour before and at least 1 hour after using this medicine.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral routeIt is best to take this medicine on an empty stomach. Take this medicine at bedtime. Do not eat 1 hour before and at least 1 hour after using this medicine.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Ongentys

Ongentys contraindications

  • This medicine is not right for everyone. Do not use it if you are allergic to opicapone, or if you have a tumor in the adrenal gland (pheochromocytoma) or nerves (paraganglioma).

Ongentys warnings

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart problems, sleeping problems, or a history of dyskinesia (trouble controlling movements) or mental illness.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may cause the following problems:Heart problems and changes in blood pressure (when used together with other medicines)New or worsening dyskinesiaUnusual changes in thoughts or behavior, including the urge to gamble or an increased sex drive

  • This medicine may make you drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ongentys interactions

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not use this medicine together with non-selective MAO inhibitors (including isocarboxazid, phenelzine, tranylcypromine).

  • Some medicines can affect how opicapone works. Tell your doctor if you are using dobutamine, dopamine, epinephrine, isoproterenol, or norepinephrine.

Ongentys side effects

Serious Side Effects

  • Compulsive behavior or intense urges you cannot control

  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw)

  • Lightheadedness, dizziness, or fainting

  • Excessive drowsiness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fast, slow, or uneven heartbeat

  • Unusual behavior, mood changes, seeing or hearing things that are not there, or thoughts of hurting yourself

Less Serious Side Effects

  • Constipation

  • Weight loss