Orencia (abatacept) is an injectable prescription drug prescribed to patients with rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), or arthritis due to psoriasis. Orencia works by suppressing the immune system response that causes these conditions. Rheumatoid arthritis and its treatment options are complex, so keep reading for more information about Orencia, how it works, possible side effects, how much Orencia costs, and how you can save money on your Orencia prescription. Orencia cost is very high, normally $6,216.35 per 3, 250mg solution reconstituteds at full price. A SingleCare Orencia coupon reduces the price to $4,549.70.
Edit your dosage
1 solution reconstituted, 250mgEdit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
Members save the most
Orencia (abatacept) is an injectable prescription drug prescribed to patients with rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), or arthritis due to psoriasis. Orencia works by suppressing the immune system response that causes these conditions. Rheumatoid arthritis and its treatment options are complex, so keep reading for more information about Orencia, how it works, possible side effects, how much Orencia costs, and how you can save money on your Orencia prescription. Orencia cost is very high, normally $6,216.35 per 3, 250mg solution reconstituteds at full price. A SingleCare Orencia coupon reduces the price to $4,549.70.
Orencia (abatacept) is an injectable prescription drug prescribed to patients with rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), or arthritis due to psoriasis. Orencia works by suppressing the immune system response that causes these conditions. Rheumatoid arthritis and its treatment options are complex, so keep reading for more information about Orencia, how it works, possible side effects, how much Orencia costs, and how you can save money on your Orencia prescription. Orencia cost is very high, normally $6,216.35 per 3, 250mg solution reconstituteds at full price. A SingleCare Orencia coupon reduces the price to $4,549.70.
Orencia is very expensive. At most pharmacies, the price of Orencia without insurance will be $6,216.35. With a SingleCare savings card, however, that same prescription will cost $4,549.70. SingleCare coupons can be used at major pharmacies throughout the country.
Copay costs of Orencia differ depending on your insurance plan and are often high. With SingleCare, Orencia costs only $4,549.70. To save money on Orencia, compare your insurance copay to SingleCare’s discount. The SingleCare cost may be substantially lower.
Some Medicare Advantage and Medicare Part D prescription drug insurance plans provide coverage for Orencia. If you are on Medicare and Orencia is not covered by your prescription plan, consider using a SingleCare Orencia coupon for your prescription. With SingleCare, the price of Orencia is $4,549.70 for 3, 250mg solution reconstituteds.
Orencia is a brand-name prescription medication. There are no generic versions of Orencia available.
Orencia (abatacept) is a prescription drug prescribed to adult patients with rheumatoid arthritis or arthritis due to psoriasis (psoriatic arthritis), or children 2 years and older with moderate to severe active polyarticular juvenile idiopathic arthritis. These forms of arthritis are caused by the body's immune system attacking healthy cells in the joints. The active ingredient in Orencia is a protein that suppresses the immune system and prevents it from attacking healthy tissues.
Orencia is either delivered by a healthcare provider as an intravenous injection or self-injected under the skin by the patient using a prefilled syringe or auto-injector.
The most common side effects of Orencia include, but are not limited to, headache, sore throat, dizziness, high blood pressure, nausea, diarrhea, cough, and infections of the respiratory tract. Allergic reactions are rare but are marked by hives, swelling, and trouble breathing. Seek emergency medical treatment if allergy symptoms occur.
Orencia suppresses the body's immune system, so infections are often the most serious side effects of Orencia, especially when Orencia is used in combination with certain medications. Consult your doctor immediately if you have an infection or symptoms of an infection. Orencia may severely exacerbate hepatitis B infections, so it is usually not prescribed for patients infected with hepatitis B.
Finally, because Orencia suppresses the immune system, Orencia reduces the effectiveness of vaccinations, and live vaccines may cause serious illnesses.
Finally, because Orencia suppresses the immune system, Orencia reduces the effectiveness of vaccinations, and live vaccines may cause serious illnesses.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved