What is Orkambi: Uses, Warnings & Interactions

How to take Orkambi

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Your doctor will tell you how much medicine to use. Do not use more than directed.

• Take this medicine with food that contains fat, including avocado, butter, cheese pizza, eggs, nuts, peanut butter, or whole milk dairy products. This helps your body absorb the medicine better.

• Granules: Mix the entire content of each packet with 1 teaspoon (5 milliliters [mL]) of cool to room temperature soft food (including puréed fruits, flavored yogurt, pudding) or liquid (including milk, juice). Take the mixture within 1 hour.

• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

• Missed dose: If it is 6 hours or less from the time you normally take your medicine, take a dose as soon as you can. If it is more than 6 hours, skip the missed dose and take your next dose at the regular time. Do not take extra medicine to make up for a missed dose.

• Your doctor will tell you how much medicine to use. Do not use more than directed.

• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

• Take this medicine with food that contains fat, including avocado, butter, cheese pizza, eggs, nuts, peanut butter, or whole milk dairy products. This helps your body absorb the medicine better.

• Missed dose: If it is 6 hours or less from the time you normally take your medicine, take a dose as soon as you can. If it is more than 6 hours, skip the missed dose and take your next dose at the regular time. Do not take extra medicine to make up for a missed dose.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Granules: Mix the entire content of each packet with 1 teaspoon (5 milliliters [mL]) of cool to room temperature soft food (including puréed fruits, flavored yogurt, pudding) or liquid (including milk, juice). Take the mixture within 1 hour.

What to do if you miss a dose of Orkambi

Orkambi contraindications

• This medicine is generally considered safe for most people. Talk to your doctor if you have concerns.

Orkambi warnings

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung problems, or high blood pressure. Tell your doctor if you have had an organ transplant.

• This medicine may cause the following problems: Liver problemsLung or breathing problemsHigh blood pressureEye or vision problems

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Trouble breathing, chest tightness or discomfort

Orkambi interactions

• Some medicines can affect how lumacaftor/ivacaftor works. Tell your doctor if you are using any of the following:Carbamazepine, clarithromycin, cyclosporine, digoxin, erythromycin, everolimus, ibuprofen, itraconazole, ketoconazole, methylprednisolone, midazolam, montelukast, phenobarbital, phenytoin, posaconazole, prednisone, rifabutin, rifampin, sirolimus, St John's wort, tacrolimus, telithromycin, triazolam, voriconazoleBirth control pills or other hormone-based contraceptives (including implants, injections, patches, rings)Blood thinner (including warfarin)Medicine to treat depression (including citalopram, escitalopram, sertraline)Oral diabetes medicine (including glimepiride, glipizide, glyburide, repaglinide)Stomach medicine (including esomeprazole, lansoprazole, omeprazole, ranitidine)

• This medicine may cause the following problems: Liver problemsVision problems

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.