What is Phenylephrine-Dextromethorphan-Guaifenesin: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Phenylephrine-Dextromethorphan-Guaifenesin overview

BRAND NAMES:

  • Actidom DMX, Actinel DM, Broncotron PED, Broncotron PED drops, Children's Giltuss Cough & Cold, Desgen Pediatric Drops, Desgen DM, Despec DM, Despec DM-G, Despec EDA, Deconex DMX, Children's Robitussin Cough & Cold CF, Children's Mucinex Multi-Symptom Cold, Children's Mucinex Cold & Stuffy Nose, Children's Mucinex Cough & Congestion

Generic Names:

  • Phenylephrine-Dm-Gg

Uses:

  • Relieves nasal congestion and cough due to respiratory tract infection.

Therapeutic Classes:

  • Antitussive/Decongestant/Expectorant Combination

Forms:

  • Long Acting Tablet, Liquid, Tablet, Capsule

How it’s taken:

  • By mouth

What is Phenylephrine-Dextromethorphan-Guaifenesin used for?

What form(s) does Phenylephrine-Dextromethorphan-Guaifenesin come in

  • Long Acting Tablet

  • Liquid

  • Tablet

  • Capsule

What are common Phenylephrine-Dextromethorphan-Guaifenesin doses?

  • Bottle 90 Tablets

  • Bottle 240ML of 10-18-200MG/15ML

How to take Phenylephrine-Dextromethorphan-Guaifenesin

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral routeIt is best to take this medicine with food or milk.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Oral routeIt is best to take this medicine with food or milk.

What to do if you miss a dose of Phenylephrine-Dextromethorphan-Guaifenesin

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Phenylephrine-Dextromethorphan-Guaifenesin contraindications

  • You should not use this medicine if you have had an allergic reaction to guaifenesin, phenylephrine, or dextromethorphan. You should not use this medicine if you have high blood pressure or heart disease. You should not use this medicine if you are using MAO inhibitors such as Eldepryl®, Marplan®, Nardil®, or Parnate®. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects.

Phenylephrine-Dextromethorphan-Guaifenesin warnings

  • Decrease in how much or how often you urinate.

  • Make sure your doctor knows if you have diabetes, enlarged prostate, glaucoma, heart disease, high blood pressure, or an overactive thyroid.

  • Make sure your doctor knows if you are breastfeeding.

  • Depression.

  • Fast heartbeat.

  • Headache or dizziness.

  • Lightheadedness.

  • Pale lips or pale skin color.

  • Seizures.

  • Trouble breathing.

Phenylephrine-Dextromethorphan-Guaifenesin interactions

  • Make sure your doctor knows if you are using tricyclic antidepressants such as amitriptyline, doxepin, nortriptyline, Elavil®, or Sinequan®.

  • Make sure your doctor knows if you are using MAO inhibitors such as Eldepryl®, Marplan®, Nardil®, or Parnate®. Tell your doctor if you are using antiyhypertensives such as guanethidine, methyldopa, mecamylamine, or reserpine.

  • Make sure your doctor knows about all the other medicines that you are using.

  • Make sure your doctor knows if you are using beta-blockers such as atenolol, labetalol, metoprolol, nadolol, propranolol, timolol, Inderal®, or Toprol®.

Phenylephrine-Dextromethorphan-Guaifenesin side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, or nervousness.

  • Decrease in how much or how often you urinate.

  • Headache or dizziness.

  • Seizures.

  • Lightheadedness.

  • Trouble breathing.

  • Depression.

  • Fast heartbeat.

  • Pale lips or pale skin color.

Less Serious Side Effects

  • Nausea.

  • Weakness in your body.

  • Tremor.