What is Plan B One-Step: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Plan B One-Step is an over-the-counter emergency contraception medication (“morning after pill”). It reduces the risk of pregnancy after unprotected sexual intercourse or barrier contraception failure. The drug contains levonorgestrel, a female sex hormone that can prevent pregnancy by blocking ovulation, fertilization, and attachment of a fertilized egg to the uterine lining.

Plan B One-Step overview

BRAND NAMES:

  • Aftera, EContra One-Step, My Choice, My Way, Next Choice, Option 2, Preventeza, Opcicon One-Step, React, Take Action

Generic Names:

  • Levonorgestrel

Uses:

  • Prevents pregnancy after unprotected sex or after failure of another birth control method.

Therapeutic Classes:

  • Contraceptive, progestin contraceptive, endocrine-metabolic agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Plan B One-Step used for?

Plan B One-Step is used to prevent pregnancy after unprotected sex or birth control failure.

What form(s) does Plan B One-Step come in

  • Tablet

    • 1.5 mg

What are common Plan B One-Step doses?

  • For emergency contraception in women: 1, 1.5 mg tablet taken within 72 hours of unprotected sexual intercourse

Common Plan B One-Step prescriptions

  • Plan B One-Step
    1 tablets package

  • Plan B One-Step
    1.5mg tablet

How to take Plan B One-Step

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Take the first tablet as soon as possible within 72 hours after unprotected sex unless directed otherwise by your doctor. 

  • If you vomit within one hour of taking the tablet, call your healthcare professional for medical advice about repeating the dose.

What to do if you miss a dose of Plan B One-Step

  • Women can take Plan B One-Step at any time within 72 hours of unprotected sex.

  • Talk to a doctor if more than 72 hours have passed after unprotected sex.

Plan B One-Step contraindications

  • This medicine is not right for everyone. 

  • You should not use Plan B One-Step if you have had an allergic reaction to it or other progestin drugs, such as progestogen oral contraceptives (Ovrette, Micronor, Nor-QD), progesterone, megestrol, or medroxyprogesterone. 

  • Do not take Plan B One-Step if you are pregnant. Plan B One-Step will not end a pregnancy.

  • You should not use Plan B One-Step if you have unusual vaginal bleeding.

Plan B One-Step warnings

  • You may have spotting a few days after using this medicine. With your next period, you may bleed a little more or a little less than usual.

  • After using this medicine, you should have your next period at the expected time. If your next period is over a week late, check with your doctor. You may be pregnant.

  • Before using this medicine, talk to a doctor first if:

    • You have ever had a tubal pregnancy

    • You have diabetes

    • You are breastfeeding

  • This medicine is an emergency method of preventing pregnancy and should not be your regular method of birth control.

  • Levonorgestrel will not protect you or your partner from sexually transmitted diseases such as syphilis, herpes, or HIV (the virus that causes AIDS).

Plan B One-Step interactions

  • Some drug interactions may cause problems in women taking Plan B One-Step. Some of these drug combinations may make Plan B One-Step less effective as an emergency contraceptive. 

  • Talk to a doctor if you are taking the following medications:

    • Anticonvulsants such as phenytoin or carbamazepine

    • Rifampin

    • Dexamethasone

  • Some common dietary supplements can also reduce the effectiveness of Plan B One-Step, so you may want to temporarily discontinue them:

    • Echinacea

    • Garlic

    • St. John’s wort

Plan B One-Step side effects

Serious side effects

  • Plan B One-Step has no reported serious side effects.

Less serious side effects

  • Menstrual changes

  • Feeling tired

  • Breast tenderness

  • Nausea

  • Headache

  • Vomiting

  • Lower abdominal pain

  • Dizziness

Sources:

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