What is Plenamine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Plenamine overview

BRAND NAMES:

  • Aminosyn, Aminosyn (pH6), Aminosyn HBC, Aminosyn II, Aminosyn II with Electrolytes, Aminosyn M w/Electrolytes, Aminosyn-PF, Aminosyn-RF, Aminosyn With Electrolytes, Clinimix, Clinimix 6/5, Clinimix 8/10, Clinimix 8/14, Clinimix E 2.75/5, Clinimix E 4.25/10

Generic Names:

  • Plenamine

Uses:

  • Parenteral nutrition provides your body with protein, vitamins, minerals, and other nutrients. Total parenteral nutrition (TPN) provides all of your daily nutrition. Peripheral parenteral nutrition (PPN) gives you some of the nutrition you need. TPN and PPN solutions are given when you cannot eat or cannot get enough nutrition from the food that you do eat.

Therapeutic Classes:

  • Parenteral Amino Acids, Parenteral Electrolyte Combination

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Plenamine used for?

What form(s) does Plenamine come in

  • Injectable

What are common Plenamine doses?

  • Vial 1000ML of 15%

  • Flex Cont 1000ML of 15%

Common Plenamine prescriptions

  • Plenamine
    1000ml of 15% vial

How to take Plenamine

  • TPN and PPN solutions are usually made by the pharmacist for your specific medical needs. Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Check the liquid in the IV bag before you use this medicine. Do not use it if the bag has a leak or the liquid is cloudy or has solid pieces in it. Get a new bag and tell your caregiver.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • TPN and PPN solutions are usually made by the pharmacist for your specific medical needs. Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Check the liquid in the IV bag before you use this medicine. Do not use it if the bag has a leak or the liquid is cloudy or has solid pieces in it. Get a new bag and tell your caregiver.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Plenamine

  • You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Injection routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. Throw away old medicine after the expiration date has passed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Plenamine contraindications

  • Make sure the doctor knows about any severe health problems you have, including liver or kidney disease, or trouble urinating. Tell the doctor about any allergy you have, especially if you are allergic to amino acids or sulfites.

Plenamine warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, asthma, or other breathing problems. Tell your doctor if you have mineral level problems in your blood (such as abnormal electrolyte levels, which may include high potassium levels or low calcium). Make sure your doctor knows if you have heart disease, stomach bleeding, or circulation problems, such as heart failure or blood-clotting problems.

  • Your IV could cause an infection. Carefully follow all instructions about how to keep the IV area clean and how to handle the TPN or PPN solution. Tell your caregiver if you have a fever; redness, swelling, or pain around the IV needle; or any other symptoms that resemble an infection.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Redness, warmth, swelling, or a lump where the needle is placed

  • Trouble breathing

  • Unexplained fever or chills

Plenamine interactions

  • Make sure your doctor knows if you are also using tetracycline. Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not add anything to the solution unless your doctor or other health caregiver has told you to.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Plenamine side effects

Serious Side Effects

  • Trouble breathing

  • Confusion, fainting

  • Unexplained fever or chills

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate

  • Redness, warmth, swelling, or a lump where the needle is placed

Less Serious Side Effects

  • Nausea or vomiting

  • Warmth or redness in your face, neck, arms, or upper chest

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