What is Polymyxin B Sulfate? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Polymyxin B Sulfate overview

BRAND NAMES:

  • PremierPro Rx Polymyxin B, PremierPro Rx Polymyxin B

Generic Names:

  • Polymyxin B Sulfate

Uses:

  • Treats infections.

Therapeutic Classes:

  • Antibiotic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Polymyxin B Sulfate used for?

What form(s) does Polymyxin B Sulfate come in?

  • Injectable

What are common Polymyxin B Sulfate dosages?

  • Solution Reconstituted 500000UNIT

  • Powder

Polymyxin B Sulfate images - What does Polymyxin B Sulfate look like?

  • Polymyxin B Sulfate
    500000unit solution reconstituted

How to take Polymyxin B Sulfate

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • A nurse or other trained health professional will give you this medicine.

  • This medicine is given as a shot into a muscle or a vein. It can also be given as a shot into your back.

  • Missed dose: Call your doctor or pharmacist for instructions. This medicine needs to be given on a fixed schedule.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • This medicine is given as a shot into a muscle or a vein. It can also be given as a shot into your back.

  • A nurse or other trained health professional will give you this medicine.

  • Missed dose: Call your doctor or pharmacist for instructions. This medicine needs to be given on a fixed schedule.

What to do if you miss a dose of Polymyxin B Sulfate

Polymyxin B Sulfate contraindications - Who shouldn't take Polymyxin B Sulfate?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to polymyxin.

Polymyxin B Sulfate warnings

  • Trouble breathing

  • Fever with a headache or stiff neck

  • Dizziness, drowsiness, or irritability

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease.

  • This medicine may cause the following problems:Kidney problemsNerve problems

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Polymyxin B Sulfate interactions & what to avoid when taking Polymyxin B Sulfate

  • Tell your doctor if you recently had surgery or a procedure that included the use of anesthesia. The muscle relaxers and anesthetics used may interact with polymyxin B.

  • Tell your doctor if you are taking or have recently taken another antibiotic, such as bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, or amikacin. You could have a higher risk of side effects if you take any of these with polymyxin B.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Call your doctor if your symptoms do not improve or if they get worse.

Polymyxin B Sulfate side effects - How does Polymyxin B Sulfate make you feel?

Serious Side Effects

  • Dizziness, drowsiness, or irritability

  • Trouble breathing

  • Diarrhea that may contain blood

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blurred vision

  • Decrease in how much or how often you urinate, bloody or cloudy urine, trouble urinating

  • Fever with a headache or stiff neck

  • Clumsiness, weakness, numbness, tingling feeling

Less Serious Side Effects

  • White spots in your mouth or throat, vaginal itching, or unusual vaginal discharge

  • Redness, pain, swelling, or a lump under your skin where the shot was given

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