What is Prevident 5000: Uses, Warnings & Interactions

Updated Sep 2, 2025  •  Published Dec 30, 2020

Colgate’s Prevident 5000 is a prescription toothpaste that contains a high dose of sodium fluoride (1.1%). As with other toothpastes, dentists prescribe Prevident 5000 or similar products to prevent tooth decay and cavities (dental caries). Prevident 5000 should only be used once daily unless a dentist instructs otherwise, though some Prevident 5000 products are meant to be used twice daily. The best time to brush with Prevident 5000 is right before bedtime.

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Prevident 5000 overview

BRAND NAMES:

  • Prevident 5000

Generic Names:

  • Sodium fluoride, sodium fluoride-potassium nitrate

Uses:

  • Helps develop healthy teeth and prevents cavities

Therapeutic Classes:

  • Dentifrice

Forms:

  • Paste

  • Gel

How it’s taken:

  • For the teeth or gums

What is Prevident 5000 used for?

Prevident 5000 Plus is a prescription toothpaste used to prevent tooth decay and cavities.

What form(s) does Prevident 5000 come in

  • Paste, gel

    • 1.1% sodium fluoride (5000 ppm fluoride)

    • 1.1% sodium fluoride/5% potassium nitrate

What are common Prevident 5000 doses?

  • For the prevention of tooth decay and cavities: Brush the teeth for two minutes with Prevident 5000 once (or twice) daily

Common Prevident 5000 prescriptions

  • Prevident 5000
    100ml of 1.1% bottle

  • Prevident 5000
    100ml of 1.1-5% bottle

  • Prevident 5000
    51gm of 1.1% tube of cream

How to take Prevident 5000

  • Follow all the dentist’s instructions.

  • Use Prevident 5000 only once per day, usually at the end of the day.

  • Prevident 5000 Enamel Protect or Prevident 5000 Sensitive also contain potassium nitrate for sensitivity and tooth whitening. 

    • Use these products twice daily, once in the morning and once at night.

  • The prescriber may instruct you to brush more than once daily with Prevident 5000.

  • Apply a thin strip of Prevident 5000 on the toothbrush.

  • Brush for two minutes.

  • Brush for one minute if you are using Prevident 5000 Enamel Protect or Prevident 5000 Sensitive.

  • Spit out the toothpaste. Do not swallow.

  • Do not eat, drink, or rinse for 30 minutes after brushing.

  • Children should rinse their mouths immediately after use and spit out the rinse.

  • Store Prevident 5000 at room temperature.

What to do if you miss a dose of Prevident 5000

  • Ask the prescriber what to do in case a dose is missed. 

  • Do not take extra medicine to make up for a missed dose.

Prevident 5000 contraindications

  • You should not use Prevident 5000 in children younger than 6 years of age unless recommended by a dentist. 

  • Do not use Prevident 5000 Enamel Protect or Prevident 5000 Sensitive in children younger than 12 years of age unless recommended by a dentist.

  • Do not use Prevident 5000 if you have had an allergic reaction to the product.

Prevident 5000 warnings

  • Tell the dentist or prescriber if you are pregnant, breastfeeding, or have allergies.

    • Pregnant or breastfeeding women may want to get medical advice from their doctor.

  • Do not swallow Prevident 5000 toothpaste or gel.

    • Ingesting large amounts of this toothpaste can cause serious side effects.

    • If a small amount is eaten (less than 5 mg sodium fluoride/kg of body weight), particularly by a child, ingesting milk or other foods rich in soluble calcium will help prevent side effects.

    • If large amounts are eaten, induce vomiting, supply soluble calcium (like milk), and get medical attention.

    • For extremely large overdoses (more than 15 mg sodium fluoride/kg), induce vomiting and go to an emergency room. One full container of Prevident 5000 Kids contains 605 mg of sodium fluoride.

  • If Denta 5000 Plus is prescribed to a child younger than 6, that child will require supervision when they brush with Denta 5000 Plus to prevent swallowing during brushing.

    • An adult should also supervise children younger than 12 to prevent swallowing.

  • Too much fluoride can cause white patches or stains on your teeth. If this happens, stop using the medicine and call the prescriber.

Prevident 5000 interactions

  • When used topically as prescribed, Prevident 5000 has no serious drug interactions.

Prevident 5000 side effects

Serious side effects

Contact a healthcare provider or get medical attention if you notice any signs or symptoms of a possible serious side effect, including:

  • Tooth discoloration

  • Overdose: Burning in the mouth, sore tongue, nausea, vomiting, diarrhea, excess salivation, stomach pain or cramping, vomiting blood

  • Allergic reactions: Itching, hives, rash, swelling of the mouth, lips, or tongue

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