What is Prochlorperazine Edisylate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Prochlorperazine Edisylate overview

BRAND NAMES:

  • PremierPro Rx Prochlorperazine Edisylate, Prochlorperazine Edisylate Novaplus

Generic Names:

  • Prochlorperazine Edisylate

Uses:

  • Treats severe nausea and vomiting. Also treats schizophrenia. This medicine is a phenothiazine.

Therapeutic Classes:

  • Antipsychotic, Antiemetic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Prochlorperazine Edisylate used for?

What form(s) does Prochlorperazine Edisylate come in

  • Injectable

What are common Prochlorperazine Edisylate doses?

  • Vial 2ML of 10MG/2ML

  • Vial 10ML of 50MG/10ML

Common Prochlorperazine Edisylate prescriptions

  • Prochlorperazine Edisylate
    2ml of 10mg/2ml vial

How to take Prochlorperazine Edisylate

  • Injection routeA nurse or other health provider will give you this medicine. This medicine is given through a needle into a muscle or vein.

  • Injection routeA nurse or other health provider will give you this medicine. This medicine is given through a needle into a muscle or vein.

What to do if you miss a dose of Prochlorperazine Edisylate

Prochlorperazine Edisylate contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to prochlorperazine or another phenothiazine medicine.

Prochlorperazine Edisylate warnings

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. Tell your doctor if you have bone marrow problems or if you have ever had a blood disorder, such as low blood cell counts.

  • If this medicine is being used by a child, tell the doctor if the child gets sick or becomes dehydrated (such as from vomiting and diarrhea). If the child becomes nervous and overly excited, do not give any more medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine if you have a myelography (type of spinal x-ray).

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • This medicine may cause the following problems:Tardive dyskinesia (a muscle disorder that could become permanent)Neuroleptic malignant syndrome (a nerve disorder that could be life-threatening)Extrapyramidal reaction (a muscle and nerve disorder)Overheating, because your body may not be able to cool down as it normally would

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, low blood pressure, glaucoma, seizures, or a history of breast cancer.

  • Yellow skin or eyes

Prochlorperazine Edisylate interactions

  • Some foods and medicines can affect how prochlorperazine works. Tell your doctor if you are also using any of the following:LithiumBlood thinner (such as warfarin)Diuretic (water pill) Blood pressure or heart medicine (such as guanethidine or propranolol)Medicine to treat seizures (such as phenytoin)

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. Tell your doctor if you have bone marrow problems or if you have ever had a blood disorder, such as low blood cell counts.

  • If this medicine is being used by a child, tell the doctor if the child gets sick or becomes dehydrated (such as from vomiting and diarrhea). If the child becomes nervous and overly excited, do not give any more medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine if you have a myelography (type of spinal x-ray).

Prochlorperazine Edisylate side effects

Serious Side Effects

  • Severe sleepiness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dizziness, lightheadedness, or fainting

  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw)

  • Fever, chills, cough, sore throat, and body aches

  • Fever, sweating, confusion, uneven heartbeat, muscle stiffness

  • Unusual bleeding, bruising, or weakness

  • Yellow skin or eyes

Less Serious Side Effects

  • Restlessness, excitement

  • Blurred vision

  • Skin redness, swelling, pain, or burning where the needle is placed

  • Mild tiredness or sleepiness

  • Missed menstrual period