What is Prograf: Uses, Warnings & Interactions

How to take Prograf

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose. Astagraf XL® (extended-release capsule): If you miss a dose and remember within 14 hours, take the missed dose right away. If more than 14 hours have passed since your regular time, skip the missed dose and return to your regular schedule.Envarsus XR® (extended-release tablet): If you miss a dose and remember within 15 hours, take the missed dose right away. If more than 15 hours have passed since your regular time, skip the missed dose and return to your regular schedule.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Use only the brand of medicine your doctor prescribed. Other brands may not work the same way.

• This medicine is always used together with other medicines. Make sure you understand when to take each medicine during the day.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

• Immediate-release capsule: You may take this medicine with or without food, but take it the same way each time. If you take it with food, then always take it with food. Do not crush, open, or chew it.

• Extended-release capsule: Take it every morning on an empty stomach at least 1 hour before or 2 hours after a meal. Swallow the extended-release capsule whole. Do not crush, break, or chew it.

• Extended-release tablet: Take it on an empty stomach, at least 1 hour before or 2 hours after a meal, at the same time every day, usually in the morning. Swallow the extended-release tablet whole. Do not crush, break, or chew it.

• Granule: You may take this medicine with or without food, but take it the same way each time. If you take it with food, then always take it with food. To prepare the oral liquid:Empty the contents of the packet in a glass cup filled with 1 to 2 tablespoons (15 to 30 milliliters) of room temperature water and mix. Use a metal spoon to stir the mixture. Do not use plastic.Drink it right away after preparing.Refill the glass cup with the same amount of water and gently swirl to mix any remaining granules to get the full dose of this medicine.You may also use an oral syringe to give this medicine.Do not inhale the granules or let the oral liquid come in contact with your skin or eyes. If you get the granules or the oral liquid on your skin, wash the area well with soap and water. If you get them into your eyes, rinse with water.Do not save the prepared oral liquid for later use.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• This medicine is always used together with other medicines. Make sure you understand when to take each medicine during the day.

• Extended-release capsule: Take it every morning on an empty stomach at least 1 hour before or 2 hours after a meal. Swallow the extended-release capsule whole. Do not crush, break, or chew it.

• Granule: You may take this medicine with or without food, but take it the same way each time. If you take it with food, then always take it with food. To prepare the oral liquid:Empty the contents of the packet in a glass cup filled with 1 to 2 tablespoons (15 to 30 milliliters) of room temperature water and mix. Use a metal spoon to stir the mixture. Do not use plastic.Drink it right away after preparing.Refill the glass cup with the same amount of water and gently swirl to mix any remaining granules to get the full dose of this medicine.You may also use an oral syringe to give this medicine.Do not inhale the granules or let the oral liquid come in contact with your skin or eyes. If you get the granules or the oral liquid on your skin, wash the area well with soap and water. If you get them into your eyes, rinse with water.Do not save the prepared oral liquid for later use.

• Immediate-release capsule: You may take this medicine with or without food, but take it the same way each time. If you take it with food, then always take it with food. Do not crush, open, or chew it.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

• Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose. Astagraf XL® (extended-release capsule): If you miss a dose and remember within 14 hours, take the missed dose right away. If more than 14 hours have passed since your regular time, skip the missed dose and return to your regular schedule.Envarsus XR® (extended-release tablet): If you miss a dose and remember within 15 hours, take the missed dose right away. If more than 15 hours have passed since your regular time, skip the missed dose and return to your regular schedule.

• Extended-release tablet: Take it on an empty stomach, at least 1 hour before or 2 hours after a meal, at the same time every day, usually in the morning. Swallow the extended-release tablet whole. Do not crush, break, or chew it.

• Use only the brand of medicine your doctor prescribed. Other brands may not work the same way.

• Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. Your doctor may let you stay for at least the first 30 minutes after the start of the infusion and at frequent intervals thereafter.

• Injection routeA nurse or other health provider will give you this medicine.

• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

• Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. Your doctor may let you stay for at least the first 30 minutes after the start of the infusion and at frequent intervals thereafter.

• Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Prograf

Prograf contraindications

• This medicine is not right for everyone. Do not use it if you had an allergic reaction to tacrolimus or polyoxyl 60 hydrogenated castor oil.

• This medicine is not right for everyone. You should not receive it if you had an allergic reaction to tacrolimus or polyoxyl 60 hydrogenated castor oil.

Prograf warnings

• This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.

• Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, diabetes, heart disease, heart rhythm problems, high blood pressure, or any type of infection.

• This medicine may cause the following problems:Increased risk of serious infectionsIncreased risk of cancer (including skin cancer, lymphoma)DiabetesHigh blood pressure, changes in heart rhythm (including QT prolongation), heart problemsBrain or nerve problems (including posterior reversible encephalopathy syndrome, seizures)Kidney problemsStomach or bowel perforation (hole or tear)

• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

• This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

• This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Increased thirst or hunger

• Rapid weight gain, swelling in your hands, ankles, or feet

• Skin changes or growths

• Sudden and severe stomach pain

• Swollen glands in your armpits or groin

• Tremors, muscle twitching, unsteadiness

• Unusual bleeding, bruising, or weakness

• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

• This medicine may cause the following problems:Increased risk of serious infectionsIncreased risk of cancer (including skin cancer, lymphoma)DiabetesHigh blood pressure, changes in heart rhythm (including QT prolongation), heart problemsBrain or nerve problems (including posterior reversible encephalopathy syndrome, seizures)Kidney problemsStomach or bowel perforation (hole or tear)

• Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, diabetes, heart disease, heart rhythm problems, high blood pressure, or any type of infection.

• This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant.

• This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

• This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Rapid weight gain, swelling in your hands, ankles, or feet

• Skin changes or growths

• Swollen glands in your armpits or groin

• Unusual bleeding, bruising, or weakness

• Weakness on one side, confusion, clumsiness, trouble thinking clearly

Prograf interactions

• This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

• Do not drink alcohol while you are using this medicine.

• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

• There are many drugs that can interact with tacrolimus. Make sure your doctor knows about all other medicines you are using.

• Do not use this medicine together with sirolimus.

• Do not use this medicine together with cyclosporine. Tacrolimus or cyclosporine should be stopped at least 24 hours before starting the other.

• Do not use this medicine together with sirolimus.

• Do not use this medicine together with cyclosporine. Tacrolimus or cyclosporine should be stopped at least 24 hours before starting the other.

• There are many drugs that can interact with tacrolimus. Make sure your doctor knows about all other medicines you are using.

• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

• This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.