What is Prometrium? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

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Prometrium overview

BRAND NAMES:

  • Prometrium

Generic Names:

  • Progesterone Micronized

Uses:

  • Helps prevent changes in the uterus in women who are taking estrogen after menopause. Also treats menstrual periods that have stopped before menopause.

Therapeutic Classes:

  • Endocrine-Metabolic Agent, Endometrial Hyperplasia Agent, Female Reproductive Agent

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Prometrium used for?

Prometrium comes in capsule form and is used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. It is also used to cause menstrual periods in women who have not yet reached menopause but are not having periods. Common side effects may include drowsiness, dizziness, breast pain, mood changes.

What form(s) does Prometrium come in?

  • Capsule

What are common Prometrium dosages?

  • Capsule 100MG

  • Capsule 200MG

Prometrium images - What does Prometrium look like?

  • Prometrium
    100mg capsule

  • Prometrium
    200mg capsule

How to take Prometrium

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine is usually taken every day for 10 to 12 days, depending on the reason you are using it. If you also take estrogen, carefully follow the schedule for both medicines together.

  • If you have trouble swallowing this medicine, take it with a glass of water while standing up. Talk to your doctor or pharmacist if this does not help.

  • Take the medicine at bedtime unless your doctor tells you otherwise.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • If you have trouble swallowing this medicine, take it with a glass of water while standing up. Talk to your doctor or pharmacist if this does not help.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • This medicine is usually taken every day for 10 to 12 days, depending on the reason you are using it. If you also take estrogen, carefully follow the schedule for both medicines together.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take the medicine at bedtime unless your doctor tells you otherwise.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Prometrium

Prometrium contraindications - Who shouldn't take Prometrium?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to progesterone or peanuts, or if you have liver disease or a history of breast cancer or blood clots (including heart attack or stroke). Do not use this medicine if you are pregnant.

Prometrium warnings

  • This medicine may cause the following problems:Blood clots, which could lead to stroke, heart attack, or other serious problemsDementia (when used together with estrogen in women older than 65)Increased risk of breast or endometrial cancer (when used together with estrogen)

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. You may also need to stop if you will be inactive for a long time. This medicine may affect certain medical test results.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, lupus, thyroid problems, or a history of depression. Tell your doctor about any problems with your heart or blood, such as heart disease, blood clotting problems, high blood pressure, or high cholesterol. Tell your doctor if you smoke.

Prometrium interactions & what to avoid when taking Prometrium

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, lupus, thyroid problems, or a history of depression. Tell your doctor about any problems with your heart or blood, such as heart disease, blood clotting problems, high blood pressure, or high cholesterol. Tell your doctor if you smoke.

  • This medicine may cause the following problems:Blood clots, which could lead to stroke, heart attack, or other serious problemsDementia (when used together with estrogen in women older than 65)Increased risk of breast or endometrial cancer (when used together with estrogen)

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. You may also need to stop if you will be inactive for a long time. This medicine may affect certain medical test results.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Prometrium side effects - How does Prometrium make you feel?

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Breast lumps

  • Chest pain, trouble breathing, or coughing up blood

  • Depression

  • Heavy or nonstop vaginal bleeding

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking

Less Serious Side Effects

  • Stomach bloating or cramps

  • Light breakthrough bleeding or spotting

  • Warmth or redness in your face, neck, arms, or upper chest

  • Breast pain or tenderness

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