What is Protopic: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Protopic overview

BRAND NAMES:

  • Protopic

Generic Names:

  • Tacrolimus

Uses:

  • Treats atopic dermatitis (a skin rash and type of eczema).

Therapeutic Classes:

  • Antipsoriatic

Forms:

  • Ointment

How it’s taken:

  • On the skin

What is Protopic used for?

Protopic is a prescription-only medication that is used to treat inflammatory symptoms including irritation and redness of the skin which is commonly associated with severe atopic dermatitis. Severe atopic dermatitis is also known as eczema. When applied onto the skin, Protopic reduces eczema-related symptoms.

What form(s) does Protopic come in

  • Ointment

What are common Protopic doses?

  • Tube 30GM of 0.03%

  • Tube 60GM of 0.03%

  • Tube 100GM of 0.03%

  • Tube 30GM of 0.1%

  • Tube 60GM of 0.1%

  • Tube 100GM of 0.1%

Common Protopic prescriptions

  • Protopic
    100gm of 0.03% tube

  • Protopic
    100gm of 0.1% tube

  • Protopic
    30gm of 0.03% tube

  • Protopic
    30gm of 0.1% tube

  • Protopic
    60gm of 0.03% tube

  • Protopic
    60gm of 0.1% tube

  • Protopic
    100gm of 0.03% tube of ointment

  • Protopic
    100gm of 0.1% tube of ointment

  • Protopic
    60gm of 0.03% tube of ointment

  • Protopic
    60gm of 0.1% tube of ointment

How to take Protopic

  • Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently. Apply the medicine 2 times daily, at least 12 hours apart, unless your doctor tells you otherwise. Apply just enough to cover the area. Only apply this medicine to areas where eczema appears.

  • You may apply a moisturizer to your skin after you apply the medicine, if your doctor approves it.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • This medicine is not for long-term use. Use the medicine only until your skin symptoms are gone. If the eczema comes back, you may start using the medicine again if your doctor approves. You must take breaks in between treatments.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Topical application routeUse this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.

  • Wash your hands before you apply this medicine. If you are not treating a skin rash on your hands, then you should also wash your hands with soap and water after you apply the medicine. However, do not wash your hands after if you are treating a rash on your hands. Do not bathe or swim immediately after applying this medicine. This could wash the medicine off.

  • Topical application routeUse this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • You may apply a moisturizer to your skin after you apply the medicine, if your doctor approves it.

  • Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently. Apply the medicine 2 times daily, at least 12 hours apart, unless your doctor tells you otherwise. Apply just enough to cover the area. Only apply this medicine to areas where eczema appears.

  • This medicine is not for long-term use. Use the medicine only until your skin symptoms are gone. If the eczema comes back, you may start using the medicine again if your doctor approves. You must take breaks in between treatments.

  • Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

  • Wash your hands before you apply this medicine. If you are not treating a skin rash on your hands, then you should also wash your hands with soap and water after you apply the medicine. However, do not wash your hands after if you are treating a rash on your hands. Do not bathe or swim immediately after applying this medicine. This could wash the medicine off.

What to do if you miss a dose of Protopic

  • Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Protopic contraindications

  • You should not use this medicine if you have had an allergic reaction to tacrolimus. Do not use this medicine on a child younger than 2 years of age.

Protopic warnings

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds. Limit your time in the sun as much as possible. Cover the treated areas of your skin with loose clothing if you must be outside.

  • Make sure your doctor knows if you are pregnant or breastfeeding. Tell your doctor if you have kidney problems, mononucleosis (mono), weakened immune system, or a history of an organ transplant. Tell your doctor if you have a skin infection, skin cancer, lymphoma, or skin absorption problems (such as lamellar ichthyosis, graft versus host disease, erythroderma, or Netherton syndrome).

  • This medicine should not be used continuously for a long time. When the rash is gone, stop using the medicine. If your doctors says it is okay, you may start using the medicine again if the rash comes back, but you should allow time in between treatments.

  • Call your doctor if your symptoms do not improve or if they get worse. Call your doctor if your symptoms do not improve within 6 weeks.

  • Rarely, patients who have used the oral or topical forms of this medicine have developed skin cancer or lymphoma. It is not known if this was related to the medcine.

  • This medicine may increase your chances of catching chicken pox, shingles, or herpes virus (including cold sores). Avoid people who have these infections. Call your doctor if you think you have been exposed to one of these illnesses.

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

  • This medicine may make you sick if it is not used correctly. Call a doctor or poison control center right away if you accidentally swallow this medicine.

Protopic interactions

  • Make sure your doctor knows if you are also using cimetidine (Tagamet®), tacrolimus capsules (Prograf®), an antibiotic such as erythromycin (Ery-tab®), or an antifungal medicine such as fluconazole, ketoconazole, itraconazole, Diflucan®, Nizoral®, or Sporanox®. Tell your doctor if you are also using blood pressure medicines such as diltiazem, nifedipine, verapamil, Adalat®, Calan®, Cardizem®, Lotrel®, Plendil®, or Procardia®.

  • Make sure your doctor knows if you are receiving any type of UV (ultraviolet) light treatment or phototherapy.

  • Alcohol may cause flushing or redness in your face.

  • Rarely, patients who have used the oral or topical forms of this medicine have developed skin cancer or lymphoma. It is not known if this was related to the medcine.

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

  • This medicine may increase your chances of catching chicken pox, shingles, or herpes virus (including cold sores). Avoid people who have these infections. Call your doctor if you think you have been exposed to one of these illnesses.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds. Limit your time in the sun as much as possible. Cover the treated areas of your skin with loose clothing if you must be outside.

  • This medicine may make you sick if it is not used correctly. Call a doctor or poison control center right away if you accidentally swallow this medicine.

Protopic side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • New skin problems, including chicken pox, shingles, or cold sores

  • Cold or flu symptoms such as fever, chills, cough, runny or stuffy nose, sore throat, and body aches

  • Swollen, painful, or tender glands in your neck, armpit, or groin

  • Mild fever

  • Swollen or infected hair follicles

Less Serious Side Effects

  • Swollen or infected hair follicles

  • Extra sensitive skin

  • Mild burning, stinging, tingling, redness, or itching when the medicine is applied

  • Mild fever

  • Acne

  • Headache

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