What is Prudoxin? Uses, warnings & side effects

What is Prudoxin? Uses, warnings & side effects

Updated May 14, 2025 • Published Dec 31, 2020

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Prudoxin overview

BRAND NAMES:

Prudoxin, Zonalon

Generic Names:

Doxepin Hcl

Uses:

Reduces itching caused by skin diseases such as atopic dermatitis or lichen simplex chronicus.

Therapeutic Classes:

Dermatological Agent

Forms:

Cream

How it’s taken:

On the skin

What is Prudoxin used for?

What form(s) does Prudoxin come in?

Cream

What are common Prudoxin dosages?

Tube 45GM of 5%

Prudoxin images - What does Prudoxin look like?

Prudoxin
45gm of 5% tube

How to take Prudoxin

Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently.
Apply a thin layer of this medicine each time you use it.
Topical application routeWash your hands with soap and water before and after you use this medicine.
Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.
Topical application routeWash your hands with soap and water before and after you use this medicine.
Topical application routeApply a thin layer of the medicine to the affected area. Rub it in gently.
Apply a thin layer of this medicine each time you use it.
Topical application routeDo not cover the treated area with a bandage unless directed by your doctor.

What to do if you miss a dose of Prudoxin

Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.
Topical application routeAsk your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Prudoxin contraindications - Who shouldn't take Prudoxin?

You should not use this medicine if you have had an allergic reaction to doxepin, or if you have glaucoma or problems urinating.

Prudoxin warnings

Make sure your doctor knows if you are pregnant or breast feeding.
This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
Drowsiness or lightheadedness or fainting.
Irregular heartbeat
Swelling in your feet, arms, or body.

Prudoxin interactions & what to avoid when taking Prudoxin

There are many other drugs that can interact with doxepin. Make sure your doctor knows about all other medicines you are using.
Make sure your doctor knows if you are using MAO inhibitors such as Eldepryl®, Marplan®, Nardil®, or Parnate®, or allergy medicines.
Make sure your doctor knows if you are using medicine for depression such as trazadone, Clexa®, Prozac®, Paxil®, or Zoloft®, or amitriptyline, Norpramin®, or Vivactil®.
Do not drink alcohol while you are using this medicine.
Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Prudoxin side effects - How does Prudoxin make you feel?

Serious Side Effects

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Confusion, hallucinations, severe weakness, vomiting, muscle stiffness.
Drowsiness or lightheadedness or fainting.
Irregular heartbeat
Swelling in your feet, arms, or body.
Redness, pain, swelling, or itching on site of cream application.
Worsening of you skin condition.

Less Serious Side Effects

Burning or stinging of your skin where the medicine in applied.
Nervousness, anxiety.
Worsening of you skin condition.
Redness, pain, swelling, or itching on site of cream application.
Headache or tiredness.
Change in taste or dryness of your mouth.
Numbness in your tongue.