What is Quinidine Sulfate: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Quinidine Sulfate overview

BRAND NAMES:

Generic Names:

  • Quinidine Sulfate

Uses:

  • Treats irregular heartbeat (arrhythmia). Also treats malaria.

Therapeutic Classes:

  • Antiarrhythmic, Group IA, Antimalarial

Forms:

  • Tablet, Capsule, Long Acting Tablet

How it’s taken:

  • By mouth

What is Quinidine Sulfate used for?

QuiNiDine Sulfate is a prescription medicine used by patients who are diagnosed with atrial fibrillation. QuiNiDine Sulfate works by decreasing the number of irregular heartbeats by thinning the blood in order to prevent a heart attack or stroke. QuiNiDine Sulfate is available in the following drug forms; oral tablet (extended release), oral tablet and injectable solution.

What form(s) does Quinidine Sulfate come in

  • Tablet

  • Capsule

  • Long Acting Tablet

What are common Quinidine Sulfate doses?

  • Tablet 200MG

  • Tablet 300MG

Common Quinidine Sulfate prescriptions

  • quiNIDine Sulfate
    200mg tablet

  • quiNIDine Sulfate
    300mg tablet

How to take Quinidine Sulfate

  • Your doctor will tell you how much to take and how often.

  • Take this medicine exactly as your doctor ordered, even if you feel fine.

  • Take on an empty stomach - 1 hour before or 2 hours after meals. Your doctor may tell you to take this medicine with food or milk to avoid stomach upset.

  • Swallow the extended-release tablet whole - do not break, chew, or crush.

  • You may need to carry identification so others will know that you are taking quinidine. Ask you doctor about this.

  • Your doctor will tell you how much to take and how often.

  • Take this medicine exactly as your doctor ordered, even if you feel fine.

  • Take on an empty stomach - 1 hour before or 2 hours after meals. Your doctor may tell you to take this medicine with food or milk to avoid stomach upset.

  • Swallow the extended-release tablet whole - do not break, chew, or crush.

  • You may need to carry identification so others will know that you are taking quinidine. Ask you doctor about this.

What to do if you miss a dose of Quinidine Sulfate

  • Take the missed dose as soon as you can unless you are more than 2 hours late, or 4 hours if you are taking extended-release tablets.

  • If you are more than 2 hours late (4 hours for the extended-release tablets), skip the missed dose and take the medicine at your usual time.

  • You should not use two doses at the same time.

Quinidine Sulfate contraindications

  • You should not use this medicine if you have ever had an allergic reaction to quinidine or quinine. You should not take this medicine if you have lupus or myasthenia gravis (a muscle disease).

Quinidine Sulfate warnings

  • Check with your doctor before taking quinidine if you have blood, kidney or liver disease, asthma, an infection, psoriasis (a skin disease), or overactive thyroid.

  • Tell your doctor or dentist that you are taking quinidine before you have any kind of surgery.

  • Do not suddenly stop taking this medicine without checking with your doctor.

  • Talk with your doctor before taking quinidine if you are pregnant or breastfeeding.

  • Quinidine may make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

  • Unusual bruising or bleeding

Quinidine Sulfate interactions

  • Make sure your doctor knows if you are taking other heart medicines such as Procan®, Lanoxin®, Cordarone®, or Inderal®, blood thinners such as Coumadin®, acetazolamide (Diamox®), or pimozide (Orap®).

  • Tell your doctor or dentist that you are taking quinidine before you have any kind of surgery.

  • Do not suddenly stop taking this medicine without checking with your doctor.

  • Talk with your doctor before taking quinidine if you are pregnant or breastfeeding.

  • Quinidine may make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

Quinidine Sulfate side effects

Serious Side Effects

  • Unusual bruising or bleeding

  • Chest pain

  • Shortness of breath or trouble breathing

  • Blurred vision or ringing in the ears

  • Fever

  • Skin rash, severe itching or hives

Less Serious Side Effects

  • Diarrhea, stomach cramps, or loss of appetite

  • Nausea or vomiting

  • Dizziness, lightheadedness, fainting

  • Headache or confusion

  • Tiredness or weakness

  • Bitter taste