What is Ranexa? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Ranexa overview

BRAND NAMES:

  • Ranexa

Generic Names:

  • Ranolazine Er

Uses:

  • Treats chronic angina (chest pain).

Therapeutic Classes:

  • Antianginal

Forms:

  • Long Acting Tablet

How it’s taken:

  • By mouth

What is Ranexa used for?

What form(s) does Ranexa come in?

  • Long Acting Tablet

What are common Ranexa dosages?

  • Bottle 60 Tablets Extended Release 12 Hour

Ranexa images - What does Ranexa look like?

  • Ranexa
    3600 tablets extended release 12 hour bottle

  • Ranexa
    60 tablets extended release 12 hour bottle

How to take Ranexa

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Ranexa

Ranexa contraindications - Who shouldn't take Ranexa?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to ranolazine, or if you have liver cirrhosis.

Ranexa warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or heart rhythm problems.

  • This medicine may cause the following problems:QT prolongation (heart rhythm problem)Kidney failure

  • Do not use this medicine to treat a sudden onset of chest pain.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ranexa interactions & what to avoid when taking Ranexa

  • Do not use this medicine together with carbamazepine, clarithromycin, itraconazole, ketoconazole, nefazodone, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, certain medicines to treat HIV or AIDS (such as indinavir, lopinavir, nelfinavir, ritonavir, saquinavir), or St John's wort.

  • Some foods and medicines can affect how ranolazine works. Tell your doctor if you are using cyclosporine, digoxin, diltiazem, erythromycin, fluconazole, lovastatin, metformin, simvastatin, sirolimus, tacrolimus, verapamil, medicine for a heart rhythm problem (such as amiodarone, dofetilide, quinidine, sotalol), medicine for depression, or medicine to treat a mental illness (such as thioridazine, ziprasidone).

  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ranexa side effects - How does Ranexa make you feel?

Serious Side Effects

  • Decrease in how much or how often you urinate

  • Fast, pounding, or uneven heartbeat

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fainting, dizziness, or lightheadedness

  • Severe or increased chest pain

  • Rapid weight gain, swelling of your hands, ankles, or feet

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