Rayaldee (calcifediol) is an FDA-approved, brand-name, prescription drug that treats hyperparathyroidism (overactive parathyroid) in people who have stage 3 or 4 kidney failure and low vitamin D levels. The active ingredient in Rayaldee, calcifediol, works by reducing parathyroid hormones in the body as well as lowering excess calcium in the body due to overactive parathyroid glands. Overactive parathyroid glands (hyperparathyroidism) are unfamiliar and confusing for most people even when they're diagnosed with the disease. So consult our FAQs for a thorough explanation of the disease and how Rayaldee treats the disease, as well as how to save money on Rayaldee. The retail price of Rayaldee is very high, currently $1,574.01. With a SingleCare Rayaldee coupon, the discounted price is $1,171.10. Keep reading for more money-saving advice about Rayaldee.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Rayaldee (calcifediol) is an FDA-approved, brand-name, prescription drug that treats hyperparathyroidism (overactive parathyroid) in people who have stage 3 or 4 kidney failure and low vitamin D levels. The active ingredient in Rayaldee, calcifediol, works by reducing parathyroid hormones in the body as well as lowering excess calcium in the body due to overactive parathyroid glands. Overactive parathyroid glands (hyperparathyroidism) are unfamiliar and confusing for most people even when they're diagnosed with the disease. So consult our FAQs for a thorough explanation of the disease and how Rayaldee treats the disease, as well as how to save money on Rayaldee. The retail price of Rayaldee is very high, currently $1,574.01. With a SingleCare Rayaldee coupon, the discounted price is $1,171.10. Keep reading for more money-saving advice about Rayaldee.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Rayaldee Retail Price | Rayaldee SingleCare Price |
|---|---|---|
| CVS Pharmacy | $1478.10 | $1249.20 |
| Walgreens | $1507.20 | $1288.80 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Rayaldee (calcifediol) is an FDA-approved, brand-name, prescription drug that treats hyperparathyroidism (overactive parathyroid) in people who have stage 3 or 4 kidney failure and low vitamin D levels. The active ingredient in Rayaldee, calcifediol, works by reducing parathyroid hormones in the body as well as lowering excess calcium in the body due to overactive parathyroid glands. Overactive parathyroid glands (hyperparathyroidism) are unfamiliar and confusing for most people even when they're diagnosed with the disease. So consult our FAQs for a thorough explanation of the disease and how Rayaldee treats the disease, as well as how to save money on Rayaldee. The retail price of Rayaldee is very high, currently $1,574.01. With a SingleCare Rayaldee coupon, the discounted price is $1,171.10. Keep reading for more money-saving advice about Rayaldee.
Rayaldee is very expensive. You will pay an average cash price of $1,574.01 for 30, 30mcg capsules extended release of Rayaldee without insurance, but $1,171.10 with a SingleCare Rayaldee prescription discount card.
Rayaldee copay costs may vary greatly depending on your insurance plan and they could be very high. With SingleCare, Rayaldee costs $1,171.10, so ask your pharmacist to compare your SingleCare price with your insurance Rayaldee copay to ensure you pay the lowest price. A SingleCare prescription savings card may save you more money than using insurance at participating pharmacies.
Rayaldee is sometimes covered by Medicare prescription drug plans. For Medicare patients without coverage for Rayaldee, consider using a free coupon from SingleCare for Rayaldee at any of a number of conveniently located pharmacies. With a SingleCare discount card, the price of Rayaldee is $1,171.10 per 30, 30mcg capsules extended release.
Rayaldee is a brand-name medication. There is no generic version of Rayaldee currently available. Rayaldee is very expensive and may not be covered by your insurance, so one way to save money is to use a SingleCare discount card at any of a number of national pharmacies or retailers. Rayaldee costs $1,171.10 with a SingleCare Rayaldee coupon.
Rayaldee is a brand-name prescription drug that treats overactive parathyroid glands (hyperparathyroidism) in patients who have stage 3 or 4 kidney failure and low vitamin D levels. The tiny parathyroid glands in the neck produce hormones that regulate the body's use of calcium. In excess, these hormones leach calcium out of the bones and put that calcium into the bloodstream. So patients with overactive parathyroid glands suffer from bone loss, bone weakness, fractures, muscle pain, bone pain, and calcium buildup in joints and soft tissues.
The active ingredient in Rayaldee, calcifediol, is a form of vitamin D3. Calcifediol helps the body use excess calcium in the bloodstream and tissues and also reduces the parathyroid production of hormones.
Rayaldee is taken once daily at bedtime. The dosage will be determined by the doctor. If you miss a dose, skip the missed dose and resume taking Rayaldee at bedtime the next day. Do not double up on doses. Before taking Rayaldee, inform your doctor of any medical conditions you have, as well as all of the medications you take (including Rx, OTC, vitamins, and supplements). People with stage 5 kidney disease or end-stage kidney disease on dialysis should not take Rayaldee.
The most common side effects of Rayaldee (some of which can be severe) are shortness of breath, constipation, cough, heart failure, osteoarthritis, anemia, and high levels of calcium and potassium. Serious side effects include anemia (low red blood cells), high levels of potassium, calcium, or phosphate in the blood, bronchitis, pneumonia, chronic obstructive pulmonary disease (COPD, which is either chronic bronchitis or emphysema), and congestive heart failure. Call your doctor right away or get emergency medical attention if you have shortness of breath, swelling, rapid weight gain, confusion, tiredness, nausea, vomiting, appetite loss, increased thirst/urination, pale skin, lightheadedness, or cold hands and feet.
Rayaldee is similar to vitamin D3, so allergic reactions are rare. Other side effects may occur. Talk with your doctor about what side effects to expect and how to address them.
Consult your healthcare professional for additional information and medical advice regarding other possible side effects and drug interactions.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved