Rebif is an FDA-approved, brand-name prescription injection that treats relapsing forms of multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system. The active ingredient in Rebif, interferon beta-1a, reduces the immune cell activity on the nerve cells, which helps treat inflammation and symptoms of MS. Continue to our FAQs section for more information about Rebif and how you can save money on your Rebif prescription. Rebif costs $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes at full price. A SingleCare Rebif coupon reduces that price to $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.
Edit your dosage
1 syringe, 0.5ml of 22mcg/0.5mlEdit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
Members save the most
Rebif is an FDA-approved, brand-name prescription injection that treats relapsing forms of multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system. The active ingredient in Rebif, interferon beta-1a, reduces the immune cell activity on the nerve cells, which helps treat inflammation and symptoms of MS. Continue to our FAQs section for more information about Rebif and how you can save money on your Rebif prescription. Rebif costs $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes at full price. A SingleCare Rebif coupon reduces that price to $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.
Rebif is an FDA-approved, brand-name prescription injection that treats relapsing forms of multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system. The active ingredient in Rebif, interferon beta-1a, reduces the immune cell activity on the nerve cells, which helps treat inflammation and symptoms of MS. Continue to our FAQs section for more information about Rebif and how you can save money on your Rebif prescription. Rebif costs $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes at full price. A SingleCare Rebif coupon reduces that price to $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.
At most pharmacies, the full retail price of Rebif will be $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes. That same prescription will cost $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes using a SingleCare savings card. A free coupon from SingleCare can be used at major pharmacies throughout the country.
Copay costs of Rebif can vary depending on the insurance plan. The copay cost, however, could be very high. With a discount coupon from SingleCare, the cost of Rebif may be lower than the cost with insurance. Ask your pharmacist to compare your Rebif insurance copay to the price with a SingleCare Rebif coupon. You may save considerably with SingleCare.
Medicare Advantage and Medicare Part D prescription drug insurance plans usually do not provide coverage for Rebif. However, some Medicare plans may help cover the cost of the medication. You can also look into using a SingleCare Rebif coupon for your prescription. With SingleCare, the discount price of Rebif is $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.
Rebif is a brand-name prescription drug. Generic versions are not available at this time.
Rebif is a brand-name prescription drug that is administered as an injection. It is used to treat relapsing forms of multiple sclerosis, a progressive disorder in which the immune system attacks and damages the body’s own nerve cells. Multiple sclerosis can lead to inflammation and cause nerves to lose their protective covering—the myelin sheath. As the myelin degenerates, nerves lose their ability to send signals and eventually die.
The active ingredient in Rebif, interferon beta-1a, decreases immune cell activity on the nerves by binding to specific receptors on immune cells to block their actions. Rebif is normally injected at a dose of 22 or 44 mcg three times per week below the skin (subcutaneously). A healthcare provider may administer the first dose. For future doses, your provider may instruct you on how to use a prefilled syringe of Rebif or a single-dose autoinjector known as Rebif Rebidose.
The most common side effects of Rebif are injection site reactions, including pain, swelling, or redness around the area of injection. Rebif may also cause flu-like symptoms that occur shortly after the injection. However, these side effects typically disappear within a day or two. Other common side effects of Rebif include, but are not limited to, headache, stomach pain, muscle pain, and fatigue.
Serious side effects of Rebif may include depression, suicidal thoughts, liver problems, blood cell disorders, decreased blood cell counts, seizures, and allergic reactions. Seek immediate medical attention if you experience signs of an allergic reaction, such as hives, rash, or trouble breathing.
Talk to a healthcare provider for additional information about other possible side effects, drug interactions, warnings, and medical advice associated with Rebif.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved