Rebif Coupons & Prices

Rebif is an FDA-approved, brand-name prescription injection that treats relapsing forms of multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system. The active ingredient in Rebif, interferon beta-1a, reduces the immune cell activity on the nerve cells, which helps treat inflammation and symptoms of MS. Continue to our FAQs section for more information about Rebif and how you can save money on your Rebif prescription. Rebif costs $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes at full price. A SingleCare Rebif coupon reduces that price to $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.

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Rebif coupon at Walgreens Pharmacy
$10268.13
$ 10,265
$3 off with signupwith signup

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Rebif coupon at Kroger Pharmacy
$10317.38
$ 10,314
$3 off with signupwith signup

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Rebif coupon at Harris Teeter Pharmacy
$10317.38
$ 10,314
$3 off with signupwith signup
Rebif coupon at Publix Pharmacy
$ 11,057
Rebif coupon at Costco Pharmacy
$11185.88
$ 11,183
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Rebif

Rebif is an FDA-approved, brand-name prescription injection that treats relapsing forms of multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system. The active ingredient in Rebif, interferon beta-1a, reduces the immune cell activity on the nerve cells, which helps treat inflammation and symptoms of MS. Continue to our FAQs section for more information about Rebif and how you can save money on your Rebif prescription. Rebif costs $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes at full price. A SingleCare Rebif coupon reduces that price to $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.

About Rebif

Rebif is an FDA-approved, brand-name prescription injection that treats relapsing forms of multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system. The active ingredient in Rebif, interferon beta-1a, reduces the immune cell activity on the nerve cells, which helps treat inflammation and symptoms of MS. Continue to our FAQs section for more information about Rebif and how you can save money on your Rebif prescription. Rebif costs $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes at full price. A SingleCare Rebif coupon reduces that price to $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.

Rebif FAQs

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

How much does Rebif cost without insurance?

At most pharmacies, the full retail price of Rebif will be $13,865.67 for 12, 0.5ml of 44mcg/0.5ml syringes. That same prescription will cost $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes using a SingleCare savings card. A free coupon from SingleCare can be used at major pharmacies throughout the country.

How much does Rebif cost with insurance?

Copay costs of Rebif can vary depending on the insurance plan. The copay cost, however, could be very high. With a discount coupon from SingleCare, the cost of Rebif may be lower than the cost with insurance. Ask your pharmacist to compare your Rebif insurance copay to the price with a SingleCare Rebif coupon. You may save considerably with SingleCare.

Does Medicare cover Rebif and how much does it cost?

Medicare Advantage and Medicare Part D prescription drug insurance plans usually do not provide coverage for Rebif. However, some Medicare plans may help cover the cost of the medication. You can also look into using a SingleCare Rebif coupon for your prescription. With SingleCare, the discount price of Rebif is $10,265.13 for 12, 0.5ml of 44mcg/0.5ml syringes.

Is there a generic of Rebif?

Rebif is a brand-name prescription drug. Generic versions are not available at this time.

What is Rebif?

Rebif is a brand-name prescription drug that is administered as an injection. It is used to treat relapsing forms of multiple sclerosis, a progressive disorder in which the immune system attacks and damages the body’s own nerve cells. Multiple sclerosis can lead to inflammation and cause nerves to lose their protective covering—the myelin sheath. As the myelin degenerates, nerves lose their ability to send signals and eventually die.

The active ingredient in Rebif, interferon beta-1a, decreases immune cell activity on the nerves by binding to specific receptors on immune cells to block their actions. Rebif is normally injected at a dose of 22 or 44 mcg three times per week below the skin (subcutaneously). A healthcare provider may administer the first dose. For future doses, your provider may instruct you on how to use a prefilled syringe of Rebif or a single-dose autoinjector known as Rebif Rebidose.

What are the side effects of Rebif?

The most common side effects of Rebif are injection site reactions, including pain, swelling, or redness around the area of injection. Rebif may also cause flu-like symptoms that occur shortly after the injection. However, these side effects typically disappear within a day or two. Other common side effects of Rebif include, but are not limited to, headache, stomach pain, muscle pain, and fatigue. 

Serious side effects of Rebif may include depression, suicidal thoughts, liver problems, blood cell disorders, decreased blood cell counts, seizures, and allergic reactions. Seek immediate medical attention if you experience signs of an allergic reaction, such as hives, rash, or trouble breathing.

Talk to a healthcare provider for additional information about other possible side effects, drug interactions, warnings, and medical advice associated with Rebif. 

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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Where are Rebif coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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