What is Rhophylac: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Rhophylac overview

BRAND NAMES:

  • HyperRHO S/D, MICRhoGAM Ultra-Filtered Plus, RhoGAM Ultra-Filtered Plus, Rhophylac, WinRho SDF

Generic Names:

  • Rhophylac

Uses:

  • Given to a pregnant woman whose blood type is Rh-negative to keep the baby's blood from interacting with the mother's. Also treats a blood cell disorder called idiopathic thrombocytopenic purpura (ITP).

Therapeutic Classes:

  • Immune Serum

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Rhophylac used for?

What form(s) does Rhophylac come in

  • Injectable

What are common Rhophylac doses?

  • Syringe 2ML of 1500UNIT/2ML

Common Rhophylac prescriptions

  • Rhophylac
    2ml of 1500unit/2ml syringe

How to take Rhophylac

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or through a needle placed in one of your veins.

  • Injection routeA nurse or other health provider will give you this medicine. .

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into a muscle or through a needle placed in one of your veins.

  • Injection routeA nurse or other health provider will give you this medicine. .

What to do if you miss a dose of Rhophylac

  • It is very important that you receive this medicine on a fixed schedule if you are using the medicine for ITP or during pregnancy. If you are unable to keep an appointment for your injection, call your doctor or caregiver for instructions.

Rhophylac contraindications

  • You should not receive Rho(D) immune globulin if you have had an allergic reaction to human immune globulin, or if you have certain bleeding problems (such as autoimmune hemolytic anemia) or immunoglobulin A (IgA) deficiency. This medicine should not be given to infants.

Rhophylac warnings

  • Pain in your lower leg (calf).

  • Check with your doctor right away if you or your child have back pain, shaking chills, a fever, dark urine, a decreased amount of urine, a sudden weight gain, swelling of the hands or feet, or shortness of breath after receiving this vaccine. These may be symptoms of a serious blood problem called intravascular hemolysis (IVH).

  • Unusual bleeding or bruising.

  • Swelling in your hands, ankles, or feet.

  • Sudden or severe headache, or problems with vision, speech, or walking.

  • Rapid weight gain.

  • Pinpoint red spots on the skin.

  • Numbness or weakness in your arm or leg, or on one side of your body.

  • Lightheadedness, dizziness, or fainting.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may cause a rare and serious lung problem a few hours after it is given. Tell your doctor right away if you or your child have any breathing problems with or without a fever after you receive the medicine.

  • This medicine may cause blood clots, especially in patients with a history of blood clotting problems, heart disease, and atherosclerosis (hardening of the arteries) or circulation problems. Patients who stay in bed for a long time because of surgery or illness may also have blood clots. Check with your doctor right away if you or your child suddenly have chest pain, shortness of breath, a severe headache, leg pain, or problems with vision, speech, or walking.

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you or your child have a history of kidney problems, anemia, blood clotting problems, heart or blood vessel problems (such as atherosclerosis), lung or breathing problems, or have had a stroke.

  • This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made from human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the making of these medicines. Although the risk is low, talk with your doctor if you have concerns.

  • This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have itching, a rash, hives, chest pain, dizziness or lightheadedness, trouble breathing, or any swelling of your hands, face, or mouth after you receive this medicine.

Rhophylac interactions

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

  • Check with your doctor right away if you or your child have back pain, shaking chills, a fever, dark urine, a decreased amount of urine, a sudden weight gain, swelling of the hands or feet, or shortness of breath after receiving this vaccine. These may be symptoms of a serious blood problem called intravascular hemolysis (IVH).

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine may cause a rare and serious lung problem a few hours after it is given. Tell your doctor right away if you or your child have any breathing problems with or without a fever after you receive the medicine.

  • This medicine may cause blood clots, especially in patients with a history of blood clotting problems, heart disease, and atherosclerosis (hardening of the arteries) or circulation problems. Patients who stay in bed for a long time because of surgery or illness may also have blood clots. Check with your doctor right away if you or your child suddenly have chest pain, shortness of breath, a severe headache, leg pain, or problems with vision, speech, or walking.

  • This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have itching, a rash, hives, chest pain, dizziness or lightheadedness, trouble breathing, or any swelling of your hands, face, or mouth after you receive this medicine.

  • This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made from human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the making of these medicines. Although the risk is low, talk with your doctor if you have concerns.

Rhophylac side effects

Serious Side Effects

  • Sudden or severe headache, or problems with vision, speech, or walking.

  • Pain in your lower leg (calf).

  • Black, bloody, or tarry stools.

  • Bloody or darkened urine.

  • Chest pain, shortness of breath, or coughing up blood.

  • Decrease in how much or how often you urinate.

  • Fast, slow, pounding, or uneven heartbeat.

  • Back pain, shaking chills, fever, or shortness of breath.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Unusual bleeding or bruising.

  • Numbness or weakness in your arm or leg, or on one side of your body.

  • Rapid weight gain.

  • Pinpoint red spots on the skin.

  • Lightheadedness, dizziness, or fainting.

  • Swelling in your hands, ankles, or feet.

Less Serious Side Effects

  • Diarrhea, nausea, or vomiting.

  • Tiredness.

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.

  • Sleepiness or unusual drowsiness.

  • Joint or muscle pain.

  • Headache.

  • Rash or itching skin.

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