Riluzole is an FDA-approved generic prescription drug that treats amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), a condition that affects the brain and spinal neurons that control voluntary muscles. Riluzole slows the process of neuron death by blocking the release of a chemical, glutamate, by the nerves in the brain and spinal cord. Although glutamate is vitally important to passing signals between nerves, too much of it is toxic to nerve cells. The pricing for Riluzole is $1,458.31 for 60, 50mg tablets, but the price with a SingleCare Riluzole coupon is $31.50 for 60, 50mg tablets.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/18/2025
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Riluzole is an FDA-approved generic prescription drug that treats amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), a condition that affects the brain and spinal neurons that control voluntary muscles. Riluzole slows the process of neuron death by blocking the release of a chemical, glutamate, by the nerves in the brain and spinal cord. Although glutamate is vitally important to passing signals between nerves, too much of it is toxic to nerve cells. The pricing for Riluzole is $1,458.31 for 60, 50mg tablets, but the price with a SingleCare Riluzole coupon is $31.50 for 60, 50mg tablets.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Riluzole Retail Price | Riluzole SingleCare Price |
|---|---|---|
| CVS Pharmacy | $1894.20 | $34.20 |
| Walmart | $84.60 | $31.80 |
| Walgreens | $700.20 | $699.80 |
| Kroger Pharmacy | $731.40 | $182.40 |
| Albertsons Pharmacy | $1839.60 | $306.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Riluzole is an FDA-approved generic prescription drug that treats amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), a condition that affects the brain and spinal neurons that control voluntary muscles. Riluzole slows the process of neuron death by blocking the release of a chemical, glutamate, by the nerves in the brain and spinal cord. Although glutamate is vitally important to passing signals between nerves, too much of it is toxic to nerve cells. The pricing for Riluzole is $1,458.31 for 60, 50mg tablets, but the price with a SingleCare Riluzole coupon is $31.50 for 60, 50mg tablets.
Uninsured customers pay an average retail price of $1,458.31 for 60, 50mg tablets, but Riluzole prices will vary depending on the Riluzole brand prescribed. Visit a nearby participating pharmacy and pay with a SingleCare Riluzole coupon for generic Riluzole. Your SingleCare discount card can reduce your prescription drug price to $31.50 for 60, 50mg tablets.
The amount of your Riluzole copay depends on your insurance plan and the brand prescribed. Riluzole costs $31.50 for 60, 50mg tablets with a SingleCare discount card, which may be lower than your insurance copay. Consult with your pharmacist to compare your cost using insurance with your savings using SingleCare.
Generic Riluzole is covered by Medicare prescription drug plans, but brand-name versions of Riluzole may not be. For patients without Medicare, a SingleCare Riluzole coupon offers significant savings at major pharmacies: CVS, Target, Walgreens, and many others.
Riluzole is a generic prescription drug that slows the progress of amyotrophic lateral disease or ALS. Riluzole is the active ingredient in the brand-name medications Rilutek (tablet), Tiglutik (oral suspension), and Exservan (oral film). Generic Riluzole tablets are available from generic manufacturers such as Mylan, Sun, Glenmark, and others. Search the SingleCare website or app for these brand-name alternatives to find additional information as well as valuable savings coupons.
Riluzole is a generic prescription drug that treats amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), a condition that kills the brain and spinal neurons that control voluntary muscles, called motor neurons. ALS nerve death is caused by glutamate, the most common substance in the brain for transmitting signals between nerve cells. Too much glutamate is toxic to nerve cells. When glutamate builds up at nerve junctions, the nerve cells kill themselves through a natural death process called apoptosis.
Riluzole slows the process of neuron death by blocking the release of glutamate by the motor neurons in the brain and spinal cord. Riluzole does not reverse or stop ALS, but does slow down the progress of the disease. Because Riluzole does not reverse motor neuron damage that has already occurred, patients and their caregivers will not notice any effect from Riluzole.
Riluzole is taken as a tablet, oral solution, or oral film (a thin film placed under the tongue until it dissolves).
The most common physical side effects of Riluzole include difficulty breathing, numbness, tingling, stomach pain, diarrhea, constipation, dry mouth, headache, dizziness, lightheadedness, vertigo, nausea, vomiting, runny nose, loss of appetite, fast heartbeat, chest pain, muscle stiffness, swelling, burning feeling in the mouth, and weakness. Serious side effects include high blood pressure, liver problems, and low white blood cell counts, creating a higher risk of infection. Allergic reactions are rare and include swelling, itching, rash, and shortness of breath. This is not a complete list of side effects that may occur. If you have questions about side effects, consult with your doctor or pharmacist.
Ask your healthcare professional for additional medical advice, drug information, and drug interactions.
Kristi C. Torres, Pharm.D., is a 2005 graduate of The University of Texas at Austin. Her professional background includes academic teaching roles, district-level management for a nationwide pharmacy chain, and clinic-based pharmacy management. Dr. Torres has a wide range of experience in pharmacy operations and has traveled to many states to open and convert clinic-based pharmacies for one of the largest healthcare systems in the nation.
Currently, she works for Tarrytown Expocare Pharmacy in Austin, Texas, serving the intellectual and developmental disability community. There, she leads the order entry team, overseeing orders from across the country.
Dr. Torres began working in pharmacy at the age of 16 in a small East Texas town. She currently resides in Round Rock, Texas, with her daughter and a Shih-Tzu puppy.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved