Shingrix, otherwise known as recombinant zoster vaccine (RZV), is an immunization to prevent reactivation of the varicella-zoster virus which causes shingles, as well as its related complications. It is recommended for most adults aged 50 years and older. Shingrix is also recommended in certain high-risk adults aged 19 years and older, such as those with a weakened immune system.
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Shingrix overview
BRAND NAMES:
Shingrix
Generic Names:
Recombinant zoster vaccine
Uses:
Prevents herpes zoster (shingles).
Therapeutic Classes:
Vaccine
Forms:
Injectable
How it’s taken:
By intramuscular (IM) injection
What is Shingrix used for?
Shingrix is used for the prevention of the virus which causes shingles, the varicella zoster virus (VZV). VZV is the same virus that causes chickenpox. A person infected with chickenpox continues to carry the virus in their body in a dormant, or inactive, state. The virus can reactivate many years later after a chickenpox infection and cause shingles, which can result in serious complications.
Expert tips for using Shingrix
Shingles vaccination with Shingrix is the only way to protect against shingles and postherpetic neuralgia (PHN), a common and serious complication of the herpes zoster virus.
Adults aged 50 years or older should receive two doses of Shingrix to prevent shingles and its complications.
Adults aged 19 years or older with weakened immune systems should also receive two doses of Shingrix.
Even if you had shingles in the past, you should still get Shingrix injections since it can help prevent future recurrences.
Shingrix should be administered even to those who do not remember having had chickenpox.
What form(s) does Shingrix come in
Suspension reconstituted, intramuscular
50 mcg/0.5 mL
What are common Shingrix doses?
Shingrix is recommended as two doses 50 mcg/0.5 mL doses administered intramuscularly separated by 2 to 6 months. For individuals who are or will be immunosuppressed, the second dose can be administered as soon as 1 to 2 months after the first dose. The preferred site for intramuscular administration is the deltoid region of the upper arm.
Common Shingrix prescriptions
Shingrix
50mcg/0.5ml suspension reconstituted
How to take Shingrix
Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
A nurse or other health provider will give you this medicine.
Call your doctor or pharmacist for instructions.
What to do if you miss a dose of Shingrix
If more than 6 months have lapsed between doses, the second dose should be administered as soon as possible. The vaccine series does not need to be restarted.
Shingrix contraindications
This medicine is not right for everyone. You should not receive it if you have a past allergic reaction to the zoster vaccine.
An individual with an acute episode of shingles should not receive Shingrix; one should wait until the acute illness is resolved.
Shingrix warnings
Tell your doctor if you are pregnant or breastfeeding, or if you have a weak immune system.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Shingrix interactions
Some medicines may affect how the zoster vaccine works. Tell your doctor if you are receiving inactivated influenza vaccine or medicine that can weaken your immune system.
Shingrix side effects
Serious side effects
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Less serious side effects
Joint or muscle pain
Headache
Pain, itching, burning, swelling, or a lump under your skin where the shot was given
Any new onset of shortness of breath, swelling of the throat or tongue, changes in vision or heart rate warrants immediate medical attention. Call 911 or seek medical care at an emergency room.
Sources:
Shingles (herpes zoster), Centers for Disease Control and Prevention (2022)
Complications of shingles, Centers for Disease Control and Prevention (2023)
Postherpetic neuralgia, Mayo Clinic (2023)
Clinical considerations for use of recombinant zoster vaccine (RZV, Shingrix) in immunocompromised adults aged >19 years, Centers for Disease Control and Prevention (2022)
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