Soliris overview
BRAND NAMES:
Soliris
Generic Names:
Soliris
Uses:
Treats paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optica spectrum disorder (NMOSD).
Therapeutic Classes:
Blood Modifier Agent
Forms:
Injectable
How it’s taken:
By injection
What is Soliris used for?
Soliris is selective immunosuppressant used for the treatment of anemia caused by paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. It is also used to treat myasthenia gravis and other conditions as prescribed by your doctor. Soliris inhibits certain proteins in the blood that usually cause the destruction of red blood cells in patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Soliris is available to children and adults as an intravenous injection.
What form(s) does Soliris come in
Injectable
What are common Soliris doses?
Vial 30ML of 300MG/30ML
Common Soliris prescriptions
Soliris
30ml of 300mg/30ml vial
How to take Soliris
Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be injected slowly, so your IV will need to stay in place for at least 35 minutes in adults and 1 to 4 hours in children.
Injection routeA nurse or other health provider will give you this medicine.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: Injection routeCall your doctor or pharmacist for instructions.
What to do if you miss a dose of Soliris
Soliris contraindications
This medicine is not right for everyone. You should not receive it if you had an allergic reaction to eculizumab or if you have a meningococcal infection. You should not receive this medicine if you have not been vaccinated against meningitis infection unless your doctor decides that urgent treatment with eculizumab is needed.
Soliris warnings
Tell your doctor if you are pregnant or breastfeeding, or if you have blood or bone marrow problems (including neutropenia), a weak immune system, or any kind of infection.
This medicine can increase your risk of serious infections, including meningococcal infection. You will need to be vaccinated against meningococcal infection at least 2 weeks before you start treatment with this medicine. You may also be given antibiotic medicines for 2 weeks to prevent infections if you are to use this medicine right away. You will also be given a patient safety card that lists the symptoms of infection and what to do if you have them. Carry the card with you at all times. Show the card to any doctor who treats you.
This medicine can also cause an infusion reaction that can be life-threatening.
For patients with PNH: When you stop receiving this medicine, you could develop hemolysis (breakdown of red blood cells). Your doctor will monitor you for at least 8 weeks.
For patients with aHUS: When you stop receiving this medicine, you could develop a type of blood clot called thrombotic microangiopathy. Your doctor will monitor you for at least 12 weeks to watch for this.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Soliris interactions
Tell your doctor if you are pregnant or breastfeeding, or if you have any kind of infection.
This medicine can increase your risk of serious infections, including meningococcal infection. You will need to be vaccinated against meningococcal infection at least 2 weeks before you start treatment with this medicine. You will also be given a patient safety card that lists the symptoms of infection and what to do if you have them. Carry the card with you at all times. Show the card to any doctor who treats you.
This medicine can also cause an infusion reaction that can be life-threatening.
For patients with PNH: When you stop receiving this medicine, you could develop hemolysis (breakdown of red blood cells). Your doctor will monitor you for at least 8 weeks.
For patients with aHUS: When you stop receiving this medicine, you could develop a type of blood clot called thrombotic microangiopathy. Your doctor will monitor you for at least 12 weeks to watch for this.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Soliris side effects
Serious Side Effects
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Change in how much or how often you urinate
Confusion, sensitivity to light, severe headache, nausea, vomiting, stiff neck
Fast or uneven heartbeat
Fever, chills, cough, sore throat, body aches
Rapid weight gain, swelling in your hands, ankles, or feet
Unusual bleeding, bruising, weakness
Less Serious Side Effects
Back pain
Diarrhea, stomach pain
Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
Runny or stuffy nose
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