What is Ultomiris: Uses, Warnings & Interactions
Ultomiris overview
BRAND NAMES:
Ultomiris
Generic Names:
Ultomiris
Uses:
Treats paroxysmal nocturnal hemoglobinuria (PNH). Also used to treat atypical hemolytic uremic syndrome (aHUS).
Therapeutic Classes:
Blood Modifier Agent
Forms:
Injectable
How it’s taken:
By injection
What is Ultomiris used for?
What form(s) does Ultomiris come in
Injectable
What are common Ultomiris doses?
Vial 3ml of 300mg/3ml
Vial 11ml of 1100mg/11ml
Common Ultomiris prescriptions
Ultomiris
11ml of 1100mg/11ml vialUltomiris
3ml of 300mg/3ml vial
How to take Ultomiris
If you are changing treatment from Soliris® to Ultomiris„¢, you should start receiving Ultomiris„¢ 2 weeks after your last dose of Soliris®.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be injected slowly, so your IV will need to stay in place for at least 2 hours.
Your doctor will monitor you for at least 1 hour for any unwanted effects after the infusion.
Injection routeA nurse or other health provider will give you this medicine.
Missed dose: Injection routeCall your doctor or pharmacist for instructions.
What to do if you miss a dose of Ultomiris
Ultomiris contraindications
This medicine is not right for everyone. You should not receive it if you had an allergic reaction to ravulizumab-cwvz, or if you have a meningococcal infection. You should not receive this medicine if you have not been vaccinated against meningitis infection unless your doctor decides that urgent treatment with ravulizumab-cwvz is needed.
Ultomiris warnings
Tell your doctor if you are pregnant, or if you have a fever, or any kind of infection.
Do not breastfeed during treatment with this medicine and for 8 months after the last dose.
This medicine can increase your risk for serious infections, including meningococcal infection. You will need to be vaccinated against meningococcal infection at least 2 weeks before you start treatment with this medicine. You may also be given antibiotic medicines for 2 weeks to prevent infections if you are to use this medicine right away. You will also be given a patient safety card that lists the symptoms of infection and what to do if you have them. Carry the card with you at all times during treatment and for 8 months after your last dose. Show the card to any doctor who treats you.
You could develop hemolysis (breakdown of red blood cells) when you stop receiving this medicine. Your doctor will monitor you for at least 16 weeks after the last dose.
You could also develop a condition called thrombotic microangiopathy (TMA) when you stop receiving this medicine for aHUS.
This medicine can also cause an infusion reaction that can be life-threatening.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Ultomiris interactions
Ultomiris side effects
Serious Side Effects
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blurred vision, slow or fast heartbeat
Chest pain, trouble breathing, dizziness, lightheadedness, or fainting, lower back pain
Confusion, sensitivity of the eye to light, severe headache, nausea, vomiting, stiff neck or back, muscle pains
Fever, chills, cough, stuffy or runny nose, sore throat, body aches
Rapid weight gain, swelling in your hands, ankles, or feet
Unusual bleeding or bruising
Less Serious Side Effects
Diarrhea, constipation, stomach pain
Hair loss
Mild headache
Pain in the arms or legs
Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
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