Check our best Sumatriptan-Naproxen prices
Treximet
Sumatriptan-Naproxen Sodium
Treats migraines. This medicine contains an NSAID.
Antimigraine
Tablet
By mouth
Tablet
Bottle 9 Tablets
SUMAtriptan-Naproxen Sodium
9 tablets bottle
Your doctor will tell you how much medicine to use. Do not use more than directed. Use only when you have a migraine. Do not use this medicine for regular headaches.
Swallow the tablet whole. Do not break, crush, or chew it.
Children 12 years of age or older: If your headache does not improve after the first dose, do not take a second dose. Call your doctor.
Adults: If your headache does not improve after the first dose, wait at least 2 hours before you take a second dose. Do not take more than 2 tablets in 24 hours.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Swallow the tablet whole. Do not break, crush, or chew it.
Adults: If your headache does not improve after the first dose, wait at least 2 hours before you take a second dose. Do not take more than 2 tablets in 24 hours.
Your doctor will tell you how much medicine to use. Do not use more than directed. Use only when you have a migraine. Do not use this medicine for regular headaches.
Children 12 years of age or older: If your headache does not improve after the first dose, do not take a second dose. Call your doctor.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
This medicine is not right for everyone. Do not use it if you had an allergic reaction (including asthma) to sumatriptan, naproxen, aspirin, or similar medicines, or if you have a history of heart disease, heart attack, angina, stroke, transient ischemic attack (TIA), ischemic bowel disease, peripheral vascular disease, or heart bypass surgery.
Sudden or severe headache, problems with vision, speech, or walking
Unexplained weight gain, swelling in your hands, ankles, or feet
Unusual bleeding, bruising, or weakness
Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy, unless your doctor says it is okay.
Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, diabetes, fluid retention, high cholesterol, heart rhythm problems, high blood pressure, or a family history of heart disease. Tell your doctor if you have a history of seizures, ulcers, or stomach or bowel bleeding. Tell your doctor if you are on a low-salt diet or if you smoke or drink alcohol.
This medicine may cause the following problems:Increased risk of blood clots, heart attack, heart rhythm problems, or strokeStomach ulcers or bleedingSerious drug reaction called serotonin syndrome (more likely when used with certain other medicines)Kidney or liver problemsSerious skin reactions
Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.
This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Seizure
Severe stomach pain, bloody or black stools
Do not use this medicine if you have taken an MAO inhibitor in the past 14 days or another migraine medicine within the past 24 hours.
Do not use other NSAIDs unless your doctor tells you it is okay. Some examples are aspirin, celecoxib, diclofenac, diflunisal, ibuprofen, or salsalate.
Some medicines can affect how sumatriptan/naproxen works. Tell your doctor if you are using any of the following:Cyclosporine, digoxin, lithium, methotrexate, pemetrexed, or probenecidBlood pressure medicineBlood thinner (including warfarin)Diuretic (water pill)Medicine to treat depressionSteroid (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)
Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.
This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Serious Side Effects
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Severe stomach pain, bloody or black stools
Unusual bleeding, bruising, or weakness
Change in how much or how often you urinate
Seizure
Unexplained weight gain, swelling in your hands, ankles, or feet
Coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
Blistering, peeling, or red skin rash
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Chest pain that may spread, trouble breathing, unusual sweating, fainting
Fast or slow, pounding, or uneven heartbeat
Anxiety, restlessness, fever, muscle spasms, diarrhea, seeing or hearing things that are not there
Chest discomfort, jaw or neck tightness
Sudden or severe headache, problems with vision, speech, or walking
Less Serious Side Effects
Vision changes that are not part of a usual migraine
Health education, drug info, wellness & more
SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved