Syprine overview
BRAND NAMES:
Chemet, Clovique, Cuprimine, Depen, Ferriprox, Ferriprox Twice-A-Day, Syprine, Jadenu, Syprine, Clovique
Generic Names:
Trientine Hcl
Uses:
Treats heavy metal poisoning. May also be used to treat rheumatoid arthritis or cystinuria (too much cystine in your urine)., Treats Wilson's disease (high levels of copper in the body) in people who cannot take penicillamine (Cuprimine®, Depen®).
Therapeutic Classes:
Heavy Metal Chelator, Antirheumatic, Heavy Metal Chelator, Renal-Urologic Agent
Forms:
Tablet, Capsule, Capsule
How it’s taken:
By mouth, By mouth
What is Syprine used for?
Syprine is a prescription-only medication that is used by patients to decrease the amount of lead, copper and metal in their blood. Patients diagnosed with Wilson’s disease use Syprine as a treatment method since it removes heavy copper particles in their blood.
What form(s) does Syprine come in
Tablet
Capsule
Capsule
What are common Syprine doses?
Capsule 250MG
Common Syprine prescriptions
Syprine
250mg capsule
How to take Syprine
Your doctor will tell you how much medicine to use. Do not use more than directed.
Oral routeIt is best to take this medicine on an empty stomach. Take your prescribed dose at least 1 hour before meals or 2 hours after meals, and at least 1 hour apart from any food, milk, or other medicines.
Swallow the capsule whole, and wash it down with water only. Do not crush, break, or chew it. Rinse any areas of your body or hands with water that may have touched the medicine inside the capsule.
For the first month that you use this medicine, take your temperature every night before you go to bed. Let your doctor know if you have a fever (body temperature elevated above 98.6 degrees F). Let your doctor know if you develop a skin rash or redness.
Oral routeIt is best to take this medicine on an empty stomach. Take your prescribed dose at least 1 hour before meals or 2 hours after meals, and at least 1 hour apart from any food, milk, or other medicines.
Swallow the capsule whole, and wash it down with water only. Do not crush, break, or chew it. Rinse any areas of your body or hands with water that may have touched the medicine inside the capsule.
Your doctor will tell you how much medicine to use. Do not use more than directed.
For the first month that you use this medicine, take your temperature every night before you go to bed. Let your doctor know if you have a fever (body temperature elevated above 98.6 degrees F). Let your doctor know if you develop a skin rash or redness.
You might need to take this medicine on an empty stomach. Take penicillamine or trientine at least 1 hour before eating a meal or 2 hours after eating a meal. Do not eat or drink milk within 1 hour of the time you take this medicine. Ask your doctor or pharmacist if you have questions about what schedule to follow.
Oral routeCarefully follow your doctor's instructions about any special diet.
Your doctor will tell you how much medicine to use. Do not use more than directed.
Do not open or chew trientine capsule. If you get any of this medicine on your skin, wash it off right away.
If you cannot swallow the succimer capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.
You might need to drink extra water while you are using this medicine.
Oral routeCarefully follow your doctor's instructions about any special diet.
Do not open or chew trientine capsule. If you get any of this medicine on your skin, wash it off right away.
If you cannot swallow the succimer capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.
Your doctor will tell you how much medicine to use. Do not use more than directed.
You might need to take this medicine on an empty stomach. Take penicillamine or trientine at least 1 hour before eating a meal or 2 hours after eating a meal. Do not eat or drink milk within 1 hour of the time you take this medicine. Ask your doctor or pharmacist if you have questions about what schedule to follow.
You might need to drink extra water while you are using this medicine.
What to do if you miss a dose of Syprine
Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
Syprine contraindications
You should not use this medicine if you have had an allergic reaction to trientine (Syprine®). You should not use this medicine to treat cystinuria (kidney, ureter, or bladder stones), rheumatoid arthritis, or biliary cirrhosis (inflammation and scarring of the liver).
Make sure your doctor knows if you have had an allergic reaction to any chelating agent such as penicillamine, succimer, or trientine. Make sure your doctor knows if you are pregnant or breastfeeding. Tell your doctor if you have kidney disease.
Syprine warnings
Make sure your doctor knows if you are pregnant or breast feeding, or if you have anemia (low levels of iron in your blood). Make sure your doctor knows if you have liver, kidney, or heart problems.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Your skin might be more fragile while you are using penicillamine, especially on your shoulders, elbows, knees, toes, or buttocks. Your skin might also heal more slowly than usual. Talk to your doctor before you have any kind of surgery, because your dose of this medicine might need to be changed.
You might need to take your temperature every night when you first start using this medicine.
For people who have diabetes: Succimer may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.
For Wilson€™s disease, you might need to use this medicine for one to three months before you notice any improvement. The symptoms of Wilson€™s disease might get worse when you first start using this medicine. If your symptoms get very bad or keep getting worse, tell your doctor.
Some people have too much heavy metal in their bodies because they were exposed to it, such as in the home or at work. The metal could still be in their surroundings. If this is your situation, then you must get rid of the metal or learn how to protect yourself. This medicine will not protect you from a heavy metal that you are still being exposed to. Find out how you were exposed. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.
Tell your doctor if you have ever used a chelating agent before.
Make sure any doctor or dentist who treats you knows that you are using this medicine.
Do not stop using this medicine without talking to your doctor first.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or problems with your blood. Tell your doctor if you are allergic to penicillin.
Syprine interactions
You might need to take your temperature every night when you first start using this medicine.
Your skin might be more fragile while you are using penicillamine, especially on your shoulders, elbows, knees, toes, or buttocks. Your skin might also heal more slowly than usual. Talk to your doctor before you have any kind of surgery, because your dose of this medicine might need to be changed.
For people who have diabetes: Succimer may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.
For Wilson€™s disease, you might need to use this medicine for one to three months before you notice any improvement. The symptoms of Wilson€™s disease might get worse when you first start using this medicine. If your symptoms get very bad or keep getting worse, tell your doctor.
Some people have too much heavy metal in their bodies because they were exposed to it, such as in the home or at work. The metal could still be in their surroundings. If this is your situation, then you must get rid of the metal or learn how to protect yourself. This medicine will not protect you from a heavy metal that you are still being exposed to. Find out how you were exposed. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.
Tell your doctor if you are also using any vitamin, mineral, or iron supplements.
Do not take any other medicine at the same time you take penicillamine. Always allow at least 1 hour between the time you take penicillamine and the time you take other medicines. If you are using a different chelating medicine, ask your doctor.
Make sure your doctor knows if you are also using phenylbutazone or medicine to treat malaria, such as mefloquine, quinine, quinidine, chloroquine, atovaquone/proguanil, Lariam®, Malarone®, Aralen®.
Tell your doctor if you have ever used a chelating agent before.
Make sure your doctor knows if you are also using any other medicines to lower the amount of metal in your body.
Make sure your doctor knows if you are also taking any mineral supplements containing calcium, iron, magnesium, phosphorus, potassium, or zinc. These minerals may be present in multivitamins as well, so make sure your doctor knows if you are taking any vitamins.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Syprine side effects
Serious Side Effects
Skin rash, itching, redness (at any time during treatment, or after treatment stops).
Unusual bleeding, bruising, or weakness.
Seizures, clumsiness.
Scaly, red, or flaky patches on your skin, or skin blisters (especially in your mouth).
Muscle weakness, drooping eyelids, double vision, trouble seeing.
Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Bloody or cloudy urine.
Fever, by itself or with chills or sore throat.
Trouble breathing, coughing up blood, unexplained cough or wheezing.
Joint pain.
Seeing double, or other vision problems.
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Tensing of muscles in your head, arms, legs, trunk, or neck that you are not able to control, or muscle twitching.
Skin rash or redness.
Less Serious Side Effects
Joint pain.
Seeing double, or other vision problems.
Skin rash or redness.
Feeling unusually tired or exhausted, or have unusual muscle weakness.
Tensing of muscles in your head, arms, legs, trunk, or neck that you are not able to control, or muscle twitching.
Nausea, vomiting, diarrhea, stomach pain, loss of appetite or ability to taste.
Sores, swelling, cracks, or white patches on your lips, mouth, or throat.
Metallic taste in your mouth.
Skin wrinkles, small white spots.
Ringing in your ears.
Unusual muscle pain, or joint pain or swelling.
Dizziness, sleepiness.
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