Syprine is an FDA approved brand-name prescription drug that removes excess copper from the body due to Wilson's disease, a condition in which the body does not remove copper from the blood. The active ingredient in Syprine, trientine, attaches to copper in the body and is excreted through the urine along with the copper. On average, the cash price of Syprine is $25,520.16 but you will pay $445.83 with a SingleCare Syprine free coupon.
Edit your dosage
30 capsule, 250mgEdit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
Members save the most
Syprine is an FDA approved brand-name prescription drug that removes excess copper from the body due to Wilson's disease, a condition in which the body does not remove copper from the blood. The active ingredient in Syprine, trientine, attaches to copper in the body and is excreted through the urine along with the copper. On average, the cash price of Syprine is $25,520.16 but you will pay $445.83 with a SingleCare Syprine free coupon.
Syprine is an FDA approved brand-name prescription drug that removes excess copper from the body due to Wilson's disease, a condition in which the body does not remove copper from the blood. The active ingredient in Syprine, trientine, attaches to copper in the body and is excreted through the urine along with the copper. On average, the cash price of Syprine is $25,520.16 but you will pay $445.83 with a SingleCare Syprine free coupon.
Patients can usually expect a retail price of $25,520.16 for Syprine. Compare this price to a SingleCare Syprine coupon, $445.83 per 100, 250mg capsules. From generics to brand name prescription drugs, you can save as much as 80% with a SingleCare prescription discount card.
The amount of your Syprine copay depends on your insurance plan. With SingleCare, Syprine costs as little as $445.83 for 100, 250mg capsules, which may be lower than your insurance copay. Ask your pharmacist to do a price comparison to find the lowest price. You may save more money with SingleCare than with insurance.
Syprine is rarely covered by Medicare Part D and Medicare Advantage prescription drug plans, but generic trientine usually is. Patients who do not have coverage can save with a SingleCare Syprine coupon and pay $445.83 for their prescription.
Syprine is a brand-name prescription drug with the active ingredient, trientine. Generic trientine is available from manufacturers such as Novadoz, Dr. Reddy's, and Amneal, among others. Search for generic trientine on the SingleCare website or app for additional information and valuable prescription savings coupons.
Syprine is a brand-name prescription drug that helps remove excess copper that has built up in the body in patients with Wilson's disease, a potentially life-threatening condition in which the body does not remove copper from the blood. As copper builds up, it damages major organs, particularly the brain and liver. The active ingredient in Syprine, trientine, attaches to copper, and is then excreted, with the copper, in the urine.
Syprine is usually prescribed to patients who were taking penicillamine to reduce copper levels but are unable to tolerate the side effects.
Syprine is taken as a capsule three to four times a day on an empty stomach.
Common side effects of Syprine include muscle spasms, weakness, loss of appetite, stomach pain, indigestion, loss of coordination or balance, mouth sores, skin rash, and flaking, dry skin. Allergic reactions are possible and may be serious, including lupus. Look for rash, itching, blisters, and fever, and immediately seek emergency medical care if symptoms occur.
This is not a complete list of side effects that may occur. Consult with your physician or healthcare professional for medical advice and any concerns you may have with side effects.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved