What is Trientine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Trientine overview

BRAND NAMES:

  • Syprine, Clovique

Generic Names:

  • Trientine Hcl

Uses:

  • Treats Wilson's disease (high levels of copper in the body) in people who cannot take penicillamine (Cuprimine®, Depen®).

Therapeutic Classes:

  • Heavy Metal Chelator

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Trientine used for?

What form(s) does Trientine come in

  • Capsule

What are common Trientine doses?

  • Capsule 250MG

Common Trientine prescriptions

  • Trientine HCl
    250mg capsule

How to take Trientine

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral routeIt is best to take this medicine on an empty stomach. Take your prescribed dose at least 1 hour before meals or 2 hours after meals, and at least 1 hour apart from any food, milk, or other medicines.

  • Swallow the capsule whole, and wash it down with water only. Do not crush, break, or chew it. Rinse any areas of your body or hands with water that may have touched the medicine inside the capsule.

  • For the first month that you use this medicine, take your temperature every night before you go to bed. Let your doctor know if you have a fever (body temperature elevated above 98.6 degrees F). Let your doctor know if you develop a skin rash or redness.

  • Oral routeIt is best to take this medicine on an empty stomach. Take your prescribed dose at least 1 hour before meals or 2 hours after meals, and at least 1 hour apart from any food, milk, or other medicines.

  • Swallow the capsule whole, and wash it down with water only. Do not crush, break, or chew it. Rinse any areas of your body or hands with water that may have touched the medicine inside the capsule.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • For the first month that you use this medicine, take your temperature every night before you go to bed. Let your doctor know if you have a fever (body temperature elevated above 98.6 degrees F). Let your doctor know if you develop a skin rash or redness.

What to do if you miss a dose of Trientine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Trientine contraindications

  • You should not use this medicine if you have had an allergic reaction to trientine (Syprine®). You should not use this medicine to treat cystinuria (kidney, ureter, or bladder stones), rheumatoid arthritis, or biliary cirrhosis (inflammation and scarring of the liver).

Trientine warnings

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have anemia (low levels of iron in your blood). Make sure your doctor knows if you have liver, kidney, or heart problems.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Trientine interactions

  • Make sure your doctor knows if you are also taking any mineral supplements containing calcium, iron, magnesium, phosphorus, potassium, or zinc. These minerals may be present in multivitamins as well, so make sure your doctor knows if you are taking any vitamins.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Trientine side effects

Serious Side Effects

  • Joint pain.

  • Seeing double, or other vision problems.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Tensing of muscles in your head, arms, legs, trunk, or neck that you are not able to control, or muscle twitching.

  • Skin rash or redness.

Less Serious Side Effects

  • Joint pain.

  • Seeing double, or other vision problems.

  • Skin rash or redness.

  • Feeling unusually tired or exhausted, or have unusual muscle weakness.

  • Tensing of muscles in your head, arms, legs, trunk, or neck that you are not able to control, or muscle twitching.

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