Learn more about systane-nighttime
Systane Nighttime is an eye lubricant ointment to help relieve dry and irritated eyes during sleep. Systane Nighttime adds a layer of oil to the eye to block the evaporation of moisture from the surface of the eye as well as lubricate the surface of the eye. On average, Systane Nighttime costs $17.85 for 1, 3.5gm tube of ointment of Systane Nighttime but you could pay $12.51 for 1, 3.5gm tube of ointment with a free SingleCare Systane Nighttime coupon. SingleCare discounts are eligible for over-the-counter products, like Systane Nighttime, when prescribed by a physician. And SingleCare is accepted at stores near you: Target, Kroger, Walgreens, and others.
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1 tube of ointment, 3.5gm of 85-15%Edit
$15.51
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$15.51
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$15.59
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$ 16.73
$19.88
$ 16.88
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About SingleCare Pricing
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 05/05/2026
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About Systane Nighttime
Systane Nighttime is an eye lubricant ointment to help relieve dry and irritated eyes during sleep. Systane Nighttime adds a layer of oil to the eye to block the evaporation of moisture from the surface of the eye as well as lubricate the surface of the eye. On average, Systane Nighttime costs $17.85 for 1, 3.5gm tube of ointment of Systane Nighttime but you could pay $12.51 for 1, 3.5gm tube of ointment with a free SingleCare Systane Nighttime coupon. SingleCare discounts are eligible for over-the-counter products, like Systane Nighttime, when prescribed by a physician. And SingleCare is accepted at stores near you: Target, Kroger, Walgreens, and others.
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Systane Nighttime Price History & Information
Price History for Systane Nighttime
1 count, tube of ointment, 3.5gmOur price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
Average 1-Month Prices for Systane Nighttime
1 count, tube of ointment, 3.5gm| Pharmacy | Systane Nighttime Retail Price | Systane Nighttime SingleCare Price |
|---|---|---|
| Walmart | - | - |
| Walgreens | $16.00 | $14.98 |
| Kroger Pharmacy | $10.99 | $10.71 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
About Systane Nighttime
Systane Nighttime is an eye lubricant ointment to help relieve dry and irritated eyes during sleep. Systane Nighttime adds a layer of oil to the eye to block the evaporation of moisture from the surface of the eye as well as lubricate the surface of the eye. On average, Systane Nighttime costs $17.85 for 1, 3.5gm tube of ointment of Systane Nighttime but you could pay $12.51 for 1, 3.5gm tube of ointment with a free SingleCare Systane Nighttime coupon. SingleCare discounts are eligible for over-the-counter products, like Systane Nighttime, when prescribed by a physician. And SingleCare is accepted at stores near you: Target, Kroger, Walgreens, and others.
Systane Nighttime FAQs
How much does Systane Nighttime cost without insurance?
The retail price of Systane Nighttime averages $17.85 for 1, 3.5gm tube of ointment of Systane Nighttime. Systane Nighttime costs only $12.51 with a Systane Nighttime coupon from SingleCare with a prescription. In fact, you can save up to 80% the retail price on many prescription drugs with a SingleCare discount card.
How much does Systane Nighttime cost with insurance?
Systane Nighttime is usually not covered by your insurance, so you will always pay full price rather than a lower, copay price. If your doctor has prescribed Systane Nighttime, with a SingleCare savings card, Systane Nighttime costs only $12.51.
Does Medicare cover Systane Nighttime and how much does it cost?
Medicare Part D and Medicare Advantage do not cover Systane Nighttime. Consider instead using a SingleCare Systane Nighttime coupon if you have a prescription for Systane Nighttime. With Single Care, the cost of Systane Nighttime drops to $12.51.
Is there a generic of Systane Nighttime?
Systane Nighttime is an over-the-counter brand-name eye gel remedy from Alcon. The active ingredients in Systane Nighttime (mineral oil and petrolatum) are found separately as the active ingredients in over-the-counter eye ointments, including generics. Both ingredients are the active ingredients in Bausch + Lomb Soothe Nighttime Dry Eye Therapy, Refresh P.M., and OCuSOFT Retaine PM. Both ingredients are also found in dry eye generic nighttime ointments such as Equate Restore PM. Explore these and other artificial tears eye drops on the SingleCare website to find useful information and discount coupons.
What is Systane Nighttime?
Systane Nighttime is an eye lubricant ointment to help relieve dry and irritated eyes during sleep. The active ingredients (petrolatum and mineral oil) coat the surface of the eye with oil that prevents surface moisture from evaporating or being removed. These oils also lubricate the surface of the eye and reduce the friction between the eyelid and the surface of the eye during sleep.
Systane Nighttime is often advised or prescribed to patients taking prescription eye drops intended to treat the underlying condition causing dry eye.
What are the side effects of Systane Nighttime?
Common side effects of Systane Nighttime are usually minor and temporary. They include but are not limited to, blurred vision, stinging, burning, irritation, and watering of the eye for a short period after the eye drops are applied. If these symptoms persist, discontinue using Systane Nighttime.
Where are Systane Nighttime coupons from SingleCare accepted?
SingleCare is accepted at most national pharmacies and grocers, including the following:
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