Systane is a family of over-the-counter artificial tears eye drops, ointments, and gel remedies for dry eye relief or irritated eyes. These eye care products add moisture to the surface of the eye and other ingredients to slow evaporation from the surface of the eye. In addition, Systane Zaditor is an antihistamine eye drop that relieves eye irritation and inflammation due to allergies. Systane also offers a family of vitamin supplements that promote general eye and vision health. On average, Systane costs $17.03 for 15, 0.4-0.3% solution (quantity in ml)s but you will pay with a free SingleCare Systane coupon. SingleCare discounts are eligible for over-the-counter products like Systane, when prescribed by a physician. And SingleCare is accepted at pharmacies near you for $8.90 for 15, 0.4-0.3% solution (quantity in ml)s.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Systane is a family of over-the-counter artificial tears eye drops, ointments, and gel remedies for dry eye relief or irritated eyes. These eye care products add moisture to the surface of the eye and other ingredients to slow evaporation from the surface of the eye. In addition, Systane Zaditor is an antihistamine eye drop that relieves eye irritation and inflammation due to allergies. Systane also offers a family of vitamin supplements that promote general eye and vision health. On average, Systane costs $17.03 for 15, 0.4-0.3% solution (quantity in ml)s but you will pay with a free SingleCare Systane coupon. SingleCare discounts are eligible for over-the-counter products like Systane, when prescribed by a physician. And SingleCare is accepted at pharmacies near you for $8.90 for 15, 0.4-0.3% solution (quantity in ml)s.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Systane Retail Price | Systane SingleCare Price |
|---|---|---|
| Walgreens | $15.90 | $15.00 |
| Kroger Pharmacy | $12.00 | $12.00 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Systane is a family of over-the-counter artificial tears eye drops, ointments, and gel remedies for dry eye relief or irritated eyes. These eye care products add moisture to the surface of the eye and other ingredients to slow evaporation from the surface of the eye. In addition, Systane Zaditor is an antihistamine eye drop that relieves eye irritation and inflammation due to allergies. Systane also offers a family of vitamin supplements that promote general eye and vision health. On average, Systane costs $17.03 for 15, 0.4-0.3% solution (quantity in ml)s but you will pay with a free SingleCare Systane coupon. SingleCare discounts are eligible for over-the-counter products like Systane, when prescribed by a physician. And SingleCare is accepted at pharmacies near you for $8.90 for 15, 0.4-0.3% solution (quantity in ml)s.
The retail price of Systane averages $17.03 for 15, 0.4-0.3% solution (quantity in ml)s. Systane costs with a Systane coupon from SingleCare with a prescription. In fact, you can save up to 80% the retail price on many prescription drugs with a free coupon from SingleCare.
Systane is usually not covered by your insurance, so you will always pay full price rather than a lower, copay price. If your doctor has prescribed Systane, with a printable coupon from SingleCare, Systane costs $8.90 for 15, 0.4-0.3% solution (quantity in ml)s.
Medicare Part D and Medicare Advantage do not cover Systane. Consider instead using a SingleCare Systane coupon if you have a prescription for Systane. With SingleCare, the cost of Systane drops to $8.90 for 15, 0.4-0.3% solution (quantity in ml)s.
Systane is an over-the-counter brand-name family of topical eye remedies from Alcon. The active ingredients in many of the products are found in over-the-counter artificial tears, including generics.
Systane is a family of over-the-counter artificial tears eye drops, ointments, and gel remedies for dry or irritated eyes. These eye health products add moisture to the surface of the eye and other ingredients to slow evaporation from the surface of the eye. In addition, Systane Zaditor is an antihistamine eye drop that relieves eye irritation and inflammation due to allergies.
Systane also offers eye vitamin supplements, lubricant eye gels, and nighttime lubricant eye ointments, which all promote general eye, vision, and personal care.
While Systane provides relief for temporary dry eye symptoms, it may not be appropriate for chronic dry eye. In that case, you may require a prescription eye drop that treats the underlying condition or illness. Consult with your physician or ophthalmologist if you suffer continually from dry eye symptoms.
Common side effects of Systane eye remedies are usually minor and temporary site reactions on the surface of the eye. They include but are not limited to blurred vision, sensitivity to light, redness, and watering of the eye for a short period after the eye drops are applied. Allergic reactions are very rare but are marked by prolonged irritation or redness of the eye, rash, itching, and trouble breathing, among others. Always discontinue Systane if you experience allergic reactions.
Consult your doctor or health care professional for additional information and medical advice.
Kristi C. Torres, Pharm.D., is a 2005 graduate of The University of Texas at Austin. Her professional background includes academic teaching roles, district-level management for a nationwide pharmacy chain, and clinic-based pharmacy management. Dr. Torres has a wide range of experience in pharmacy operations and has traveled to many states to open and convert clinic-based pharmacies for one of the largest healthcare systems in the nation.
Currently, she works for Tarrytown Expocare Pharmacy in Austin, Texas, serving the intellectual and developmental disability community. There, she leads the order entry team, overseeing orders from across the country.
Dr. Torres began working in pharmacy at the age of 16 in a small East Texas town. She currently resides in Round Rock, Texas, with her daughter and a Shih-Tzu puppy.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved