Systane Ultra is a brand of eye drop used to relieve dry and irritated eyes. It works to keep eyes lubricated and moist, helping to protect from injury and infection and decreasing symptoms of dry eyes such as itching, burning, and feeling as if something is in your eye. The average price of Systane Ultra is usually around $22.03 for 10, 0.4-0.3% solution (quantity in ml)s. Save money on your prescription and reduce your refill cost to $12.95 by using a SingleCare Systane Ultra coupon at participating pharmacies such as Harris Teeter, Walgreens, Duane Reade, and more.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 06/18/2026
Systane Ultra is a brand of eye drop used to relieve dry and irritated eyes. It works to keep eyes lubricated and moist, helping to protect from injury and infection and decreasing symptoms of dry eyes such as itching, burning, and feeling as if something is in your eye. The average price of Systane Ultra is usually around $22.03 for 10, 0.4-0.3% solution (quantity in ml)s. Save money on your prescription and reduce your refill cost to $12.95 by using a SingleCare Systane Ultra coupon at participating pharmacies such as Harris Teeter, Walgreens, Duane Reade, and more.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Systane Ultra Retail Price | Systane Ultra SingleCare Price |
|---|---|---|
| Walmart | $13.40 | $13.40 |
| Walgreens | $14.50 | $14.50 |
| Kroger Pharmacy | $9.20 | $9.10 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Systane Ultra is a brand of eye drop used to relieve dry and irritated eyes. It works to keep eyes lubricated and moist, helping to protect from injury and infection and decreasing symptoms of dry eyes such as itching, burning, and feeling as if something is in your eye. The average price of Systane Ultra is usually around $22.03 for 10, 0.4-0.3% solution (quantity in ml)s. Save money on your prescription and reduce your refill cost to $12.95 by using a SingleCare Systane Ultra coupon at participating pharmacies such as Harris Teeter, Walgreens, Duane Reade, and more.
If you do not have health insurance coverage, the cost of Systane Ultra can be around $22.03 for 10, 0.4-0.3% solution (quantity in ml)s of Systane Ultra. With the ever-increasing price of medications on the market, it is safe to say that everyone is interested in saving money. You can do so by using a SingleCare savings card and paying as low as $12.95 for your Systane Ultra refill.
Health insurance companies generally cover prescription medications only. Therefore, the cost of your Systane Ultra medication might not be covered by insurance unless your doctor writes a prescription for it. Contact your health insurance provider to find out how much Systane Ultra costs under its coverage.
SingleCare can help you to save on your medication by paying $12.95 for Systane Ultra. This may even work out cheaper than with your insurance. Check with your participating pharmacies, such as CVS Pharmacy, Target, Longs Drugs, or Walmart, to compare prices and see how you can save the most on this and any prescription drugs you may be using.
As an over-the-counter medicine, Systane Ultra is not often covered by Medicare. Luckily, you can still save money on this medication. Just use SingleCare's discount card and pay as little as $12.95 for your Systane Ultra medication. Check with your local pharmacist to learn more about savings for Systane Ultra and other medications that you are currently using.
Systane Ultra is a brand-name medication for which there is no generic version.
Systane Ultra is a brand-name lubricant eye drop used to relieve dry, irritated eyes. Dry eyes can be caused by wind, sun, heating or air conditioning, reading or computer use, and certain medications. Systane Ultra helps to lubricate your eyes and keep them moist. It also helps to protect your eyes from infection and injury and decreases the symptoms of dry eyes, such as burning and itching. Systane Ultra is available as a lubricant eye gel as well.
Systane Ultra lubricant eye drops are usually used as often as needed, sometimes one to two times per day. You should always wash your hands before using Systane Ultra. Ensure that the medication dropper does not touch your eye when you are applying these drops. If you are wearing contact lenses, you should remove them before using Systane Ultra or any kind of eye lubricant.
Systane Ultra is an over-the-counter (OTC) personal care product meant to assist with dry eye relief, however, some unwanted side effects may also occur. Some of these may include temporarily blurred vision and minor burning or stinging when first used. Tell your doctor or pharmacist immediately if any of these side effects persist or worsen.
Serious allergic reactions are often rare but you should seek immediate medical attention if you start to experience symptoms of an allergic reaction such as itching, swelling, rashes, trouble breathing, and severe dizziness.
This is not a complete list of side effects so be sure to check with your healthcare provider before using Systane Ultra to learn about all the benefits and risks associated with treatment.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved