What is Thioridazine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Thioridazine overview

BRAND NAMES:

Generic Names:

  • Thioridazine Hcl

Uses:

  • Treats the symptoms of schizophrenia.

Therapeutic Classes:

  • Antipsychotic

Forms:

  • Tablet, Liquid

How it’s taken:

  • By mouth

What is Thioridazine used for?

What form(s) does Thioridazine come in

  • Tablet

  • Liquid

What are common Thioridazine doses?

  • Tablet 10MG

  • Tablet 25MG

  • Tablet 50MG

  • Tablet 100MG

Common Thioridazine prescriptions

  • Thioridazine HCl
    100mg tablet

  • Thioridazine HCl
    10mg tablet

  • Thioridazine HCl
    25mg tablet

  • Thioridazine HCl
    50mg tablet

How to take Thioridazine

  • Your doctor will tell you how much of this medicine to take and how often. Your dose may need to be changed several times in order to find out the what works best for you. Do not take more medicine or take it more often than your doctor tells you to.

  • Measure the oral liquid medicine with a marked measuring spoon or medicine cup, or use the dropper that came with the medicine.

  • You may mix the oral liquid concentrate with a half glass of distilled water or orange juice. Mix only enough medicine for one dose and drink all the liquid right away.

  • Your doctor will tell you how much of this medicine to take and how often. Your dose may need to be changed several times in order to find out the what works best for you. Do not take more medicine or take it more often than your doctor tells you to.

  • Measure the oral liquid medicine with a marked measuring spoon or medicine cup, or use the dropper that came with the medicine.

  • You may mix the oral liquid concentrate with a half glass of distilled water or orange juice. Mix only enough medicine for one dose and drink all the liquid right away.

What to do if you miss a dose of Thioridazine

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

Thioridazine contraindications

  • You should not use this medicine if you have had an allergic reaction to thioridazine, if you have a history of heart rhythm problems or extreme high or low blood pressure, or if you have a genetic defect involving an enzyme called cytochrome P450. You should not take thioridazine if you are also taking medicines for depression (such as amitriptyline, Paxil®, Prozac®, Zoloft®), blood pressure medicine (such as atenolol, metoprolol, propranolol), medicines for heart rhythm problems, or other antipsychotic medicines (Haldol®, Risperdal®). There are many other medicines, including over-the-counter medicines, that you should not use while you are taking thioridazine. Make sure your doctor knows about all other medicines you are using.

Thioridazine warnings

  • If you are pregnant or breast feeding, talk to your doctor before taking this medicine. False positive (incorrect) pregnancy tests have been reported in patients taking this medicine.

  • Check with your doctor before taking thioridazine if you have an unusually slow heartbeat, low levels of potassium in your blood, seizures, or heart disease, or if you have ever had breast cancer. Also, tell your doctor if you have ever had a reaction to similar medicines, such as Thorazine® or Trilafon®.

  • Thioridazine can make some people feel dizzy or drowsy. Be careful if driving a car or operating machinery.

  • Muscle spasms of the neck, face, or tongue, or other body movements you cannot control

  • Severe chest pain

  • Trouble breathing

  • Unusual bleeding or bruising, seizures (convulsions)

Thioridazine interactions

  • Certain drugs should not be used while using thioridazine. Using these drugs can cause very serious medical problems, heart problems, or even death.

  • Avoid drinking alcohol.

  • Make sure your doctor knows if you are using any medicines that make you sleepy (such as sleeping pills, cold and allergy medicine, narcotic pain killers, or sedatives).

Thioridazine side effects

Serious Side Effects

  • Dizziness, fainting

  • Fever, severe muscle stiffness, excessive sweating

  • Irregular or fast heartbeat

  • Muscle spasms of the neck, face, or tongue, or other body movements you cannot control

  • Severe chest pain

  • Trouble breathing

  • Unusual bleeding or bruising, seizures (convulsions)

Less Serious Side Effects

  • Lightheadedness, especially when standing up

  • Tremors or shaking

  • Changes in menstrual cycle

  • Changes in vision, such as trouble focusing, changes in how you see colors, or trouble seeing at night

  • Nausea, vomiting, diarrhea, or constipation

  • Sleepiness

  • Dry mouth

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