Trifluridine is an antiviral prescription eye drop to treat eye infections caused by the herpes simplex virus. Trifluridine controls herpes simplex infections by interfering with the virus's ability to replicate. On average, Trifluridine costs $367.36 for 7.50, 1% solution (quantity in ml)s but you will pay $178.53 for 7.5, 1% solution (quantity in ml)s with a free SingleCare Trifluridine coupon.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/20/2025
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Trifluridine is an antiviral prescription eye drop to treat eye infections caused by the herpes simplex virus. Trifluridine controls herpes simplex infections by interfering with the virus's ability to replicate. On average, Trifluridine costs $367.36 for 7.50, 1% solution (quantity in ml)s but you will pay $178.53 for 7.5, 1% solution (quantity in ml)s with a free SingleCare Trifluridine coupon.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Trifluridine Retail Price | Trifluridine SingleCare Price |
|---|---|---|
| CVS Pharmacy | $335.85 | $219.00 |
| Walmart | $243.30 | $219.90 |
| Walgreens | $339.98 | $218.70 |
| Kroger Pharmacy | $170.85 | $170.81 |
| Albertsons Pharmacy | $318.53 | $208.72 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Trifluridine is an antiviral prescription eye drop to treat eye infections caused by the herpes simplex virus. Trifluridine controls herpes simplex infections by interfering with the virus's ability to replicate. On average, Trifluridine costs $367.36 for 7.50, 1% solution (quantity in ml)s but you will pay $178.53 for 7.5, 1% solution (quantity in ml)s with a free SingleCare Trifluridine coupon.
Patients can usually expect to pay $367.36 for 7.50, 1% solution (quantity in ml)s for Trifluridine. Compare this price to a SingleCare Trifluridine coupon: $178.53 for 7.5, 1% solution (quantity in ml)s. From generics to brand name prescription drugs, you can save as much as 80% with a SingleCare savings card.
The amount of your Trifluridine copay depends on your insurance plan. With SingleCare, Trifluridine costs as little as $178.53 for 7.5, 1% solution (quantity in ml)s which may be lower than your insurance copay. Ask your pharmacist to do a price comparison. You may save more money with SingleCare than with insurance.
Trifluridine is usually covered by Medicare Part D and Medicare Advantage prescription drug plans, but its brand-name version, Viroptic, is not. Patients without Medicare can save with a SingleCare Trifluridine coupon and pay $178.53 for 7.5, 1% solution (quantity in ml)s for their prescription.
Trifluridine is a generic drug manufactured by several companies including Hi-Tech, Sandoz, and Apotex, and is the active ingredient in the brand-name prescription eye drops, Viroptic. Search the SingleCare website or app for Viroptic or Trifluridine to find useful background information and savings coupons.
Trifluridine is an antiviral prescription eye drop to treat eye infections caused by the herpes simplex virus. Ocular herpes simplex is a recurrent and difficult infection to treat and can cause swelling or ulcers in the eyelids or cornea (surface of the eyeball). Trifluridine only treats eye infections due to the herpes simplex virus and does not treat infections due to bacteria or fungus.
The active ingredient in Trifluridine belongs to a class of antiviral drugs called nucleoside analogues that work by inserting themselves into virus DNA and shutting down virus replication.
Common side effects of Trifluridine are usually topical reactions that occur when the drops are first applied, such as burning, stinging, irritation, and swelling.
Allergic reactions are rare and may include hives, facial swelling, and difficulty breathing. Allergic reactions require emergency medical attention. This is not a complete list of side effects that may occur. Consult with your physician about any concerns you may have with side effects.
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