Vagisil is an over-the-counter medication used to provide relief from external vaginal itch. Both the regular strength and maximum strength versions contain two topical anesthetics: benzocaine and resorcinol. Because Vagisil is used only on the skin, side effects are usually limited to irritation, itching, and other skin complaints where the cream is applied.
Monistat Care Instant Itch Relief Spray, Benzal Vagisil Creme, Vagicaine (generic brand name)
Benzocaine-resorcinol
Temporarily relieves external vaginal itch
Topical anesthetic, external analgesic, antipruritic
Cream
On the skin
Vagisil is used to provide temporary relief from external vaginal itch.
Cream
5% benzocaine, 2% resorcinol
20% benzocaine, 3% resorcinol
For external vaginal itch: Apply a fingertip amount (about 1 inch) to the affected area no more than 3–4 times a day
Read the directions on the package or package insert.
Apply Vagisil only to the outside of the genitals.
Avoid getting Vagisil on your eyes or in your nose or mouth.
Do not apply Vagisil over wide areas of the skin.
How to apply Vagisil
Wash your hands with soap and water before and after you use this medicine.
Apply a fingertip amount (about 1 inch) to the affected skin.
Clean the nozzle before replacing the cap.
Do not use more than three or four times daily.
Store this medicine at room temperature with the cap attached.
Vagisil is administered on an as-needed basis. If you miss a dose, take it when remembered. Do not apply Vagisil to the skin more than three or four times daily.
This medicine is not right for everyone.
Do not use this medicine if
You have had an allergic reaction to benzocaine or any numbing medicine in the past, particularly any drug ending in –caine such as lidocaine or tetracaine.
Because of the risk of serious side effects, Vagisil should not be applied to large areas of the skin.
Before using this medicine, talk to a doctor if:
You are pregnant
You are breastfeeding
You have an unusual vaginal discharge, odor, open sores, or other signs of a vaginal bacterial infection
You plan to use it on a child younger than 12 years old
Stop using this medicine and talk to a doctor if:
The condition or symptoms worsen
Symptoms last longer than 7 days
Symptoms return after going away with treatment
You experience swelling or a rash
As a topical medicine, Vagisil is unlikely to have serious drug interactions. However, make sure you tell healthcare providers you are using this medicine if they are prescribing other medications.
Vagisil is more likely to cause serious side effects when combined with other topical drugs similar to benzocaine, such as lidocaine and prilocaine.
Serious side effects
Vagisil can cause serious side effects, especially if it is used incorrectly or ingested. Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:
Chest pain or an uneven heartbeat
Confusion, dizziness, lightheadedness, or drowsiness
Blurred or double vision
Trembling (shaking)
Swelling in the area where this medicine is applied
Skin rash
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Less serious side effects
Skin irritation
Itching
Redness
Pain
Vagisil anti-itch crème regular strength drug information, NIH National Library of Medicine
Vagisil anti-itch crème maximum strength drug information, NIH National Library of Medicine
Health education, drug info, wellness & more
SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved