What is Vagisil: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Vagisil is an over-the-counter medication used to provide relief from external vaginal itch. Both the regular strength and maximum strength versions contain two topical anesthetics: benzocaine and resorcinol. Because Vagisil is used only on the skin, side effects are usually limited to irritation, itching, and other skin complaints where the cream is applied.

Vagisil overview

BRAND NAMES:

  • Monistat Care Instant Itch Relief Spray, Benzal Vagisil Creme, Vagicaine (generic brand name)

Generic Names:

  • Benzocaine-resorcinol

Uses:

  • Temporarily relieves external vaginal itch

Therapeutic Classes:

  • Topical anesthetic, external analgesic, antipruritic

Forms:

  • Cream

How it’s taken:

  • On the skin

What is Vagisil used for?

Vagisil is used to provide temporary relief from external vaginal itch.

What form(s) does Vagisil come in

  • Cream

    • 5% benzocaine, 2% resorcinol

    • 20% benzocaine, 3% resorcinol

What are common Vagisil doses?

For external vaginal itch: Apply a fingertip amount (about 1 inch) to the affected area no more than 3–4 times a day

How to take Vagisil

  • Read the directions on the package or package insert.

  • Apply Vagisil only to the outside of the genitals. 

  • Avoid getting Vagisil on your eyes or in your nose or mouth.

  • Do not apply Vagisil over wide areas of the skin.

  • How to apply Vagisil

    • Wash your hands with soap and water before and after you use this medicine.

    • Apply a fingertip amount (about 1 inch) to the affected skin.

    • Clean the nozzle before replacing the cap.

    • Do not use more than three or four times daily.

  • Store this medicine at room temperature with the cap attached.

What to do if you miss a dose of Vagisil

  • Vagisil is administered on an as-needed basis. If you miss a dose, take it when remembered. Do not apply Vagisil to the skin more than three or four times daily.

Vagisil contraindications

  • This medicine is not right for everyone. 

  • Do not use this medicine if

    • You have had an allergic reaction to benzocaine or any numbing medicine in the past, particularly any drug ending in –caine such as lidocaine or tetracaine. 

  • Because of the risk of serious side effects, Vagisil should not be applied to large areas of the skin.

Vagisil warnings

  • Before using this medicine, talk to a doctor if:

    • You are pregnant

    • You are breastfeeding

    • You have an unusual vaginal discharge, odor, open sores, or other signs of a vaginal bacterial infection

    • You plan to use it on a child younger than 12 years old

  • Stop using this medicine and talk to a doctor if:

    • The condition or symptoms worsen

    • Symptoms last longer than 7 days

    • Symptoms return after going away with treatment

    • You experience swelling or a rash

Vagisil interactions

  • As a topical medicine, Vagisil is unlikely to have serious drug interactions. However, make sure you tell healthcare providers you are using this medicine if they are prescribing other medications.

  • Vagisil is more likely to cause serious side effects when combined with other topical drugs similar to benzocaine, such as lidocaine and prilocaine.

Vagisil side effects

Serious side effects

Vagisil can cause serious side effects, especially if it is used incorrectly or ingested. Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Chest pain or an uneven heartbeat

  • Confusion, dizziness, lightheadedness, or drowsiness

  • Blurred or double vision

  • Trembling (shaking)

  • Swelling in the area where this medicine is applied

  • Skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less serious side effects

  • Skin irritation

  • Itching

  • Redness

  • Pain