What is Xcopri: Uses, Warnings & Interactions

Follow all the prescriber’s instructions.

Please read the Medication Guide included with the medicine.

Patients start with three Xcopri titration packs, one for the first month of treatment, one for the second, and one for the third. 

• Use the 12.5-25 pack for the first 28 days of treatment.

• Start the 50-100 pack the day after finishing the first pack.

• Start the 150-200 pack the day after finishing the second pack.

• The tablets in each pack are numbered from one to 28.

• Start with the tablet marked “1.”

• Take all the tablets in order.

Take tablets once daily at any time of day.

Tablets can be taken with or without food.

Swallow the tablet whole with a drink of water.

If swallowing tablets is difficult, crush the tablet, mix it with water, and take it that way.

The tablet can also be crushed and mixed with water for use in a nasogastric feeding tube.

Do not stop taking doses until you’ve talked to the prescribing healthcare provider.

Take a dose as soon as you remember. 

If it is almost time for your next dose, wait until then and take a regular dose. 

Do not take extra medicine to make up for a missed dose.

This medicine is not right for everyone. 

Do not use it if you have:

• A heart rhythm disorder called familial short QT syndrome

• Known hypersensitivity to cenobamate.

Tell other healthcare professionals providing treatment that you are taking Xcopri.

The prescriber requires regular checkups and lab tests to monitor treatment and watch for side effects. Keep all appointments.

Before starting this medication, tell the prescriber if you are pregnant, breastfeeding, or have:

• A history of depression, suicide, suicidal thoughts, or mood problems

• Liver problems

• Kidney problems

• Blood problems

• Any past allergic reaction that involved a skin rash or affected internal organs

If you become pregnant while taking Xcopri, immediately tell the prescriber.

Cenobamate can cause dizziness, drowsiness, poor coordination, and vision problems. 

• Avoid driving, using machines, or doing anything else that could be dangerous until you know how the medicine affects you.

Do not stop using this medicine suddenly. The doctor will need to slowly decrease your dose for two weeks before you stop it completely.

Xcopri can be habit-forming and lead to abuse. 

• Do not use more than prescribed. 

• Call the prescriber if the drug does not seem to be working.

Xcopri is a federally controlled substance. Giving or selling this medicine to another person is dangerous and illegal.

Before starting Xcopri, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medicines, and supplements being taken, particularly:

• Birth control pills

• Other antiseizure drugs, including benzodiazepines or barbiturates

• Drugs that make you sleepy, including alcohol, sleeping pills, narcotic pain relievers, and allergy medications

Do not drink alcohol while you are using this medicine.

Tell other prescribers about Xcopri before they prescribe new medications.