Xerese is a brand-name topical medication used to treat cold sores, or herpes labialis. It is applied on the affected area of the skin to help reduce the risk of ulcerative cold sores and shorten the healing time of the lesions. This medication is approved for use in adults and children aged 6 years and older. It contains acyclovir and hydrocortisone. There is currently no generic version of Xerese available. The average retail price of Xerese is $1,659.79 or 1, 5gm of 5-1% tube. SingleCare may help you to reduce this price to $1,322.73 for 1, 5gm of 5-1% tube of generic Xerese with a SingleCare Xerese coupon. This coupon can be redeemed at participating pharmacies, such as CVS Pharmacy, Target, Walmart Pharmacy, Kroger, Rite Aid, and Walgreens.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Xerese is a brand-name topical medication used to treat cold sores, or herpes labialis. It is applied on the affected area of the skin to help reduce the risk of ulcerative cold sores and shorten the healing time of the lesions. This medication is approved for use in adults and children aged 6 years and older. It contains acyclovir and hydrocortisone. There is currently no generic version of Xerese available. The average retail price of Xerese is $1,659.79 or 1, 5gm of 5-1% tube. SingleCare may help you to reduce this price to $1,322.73 for 1, 5gm of 5-1% tube of generic Xerese with a SingleCare Xerese coupon. This coupon can be redeemed at participating pharmacies, such as CVS Pharmacy, Target, Walmart Pharmacy, Kroger, Rite Aid, and Walgreens.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Xerese Retail Price | Xerese SingleCare Price |
|---|---|---|
| CVS Pharmacy | $1592.00 | $1394.90 |
| Kroger Pharmacy | $1782.50 | $1325.75 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Xerese is a brand-name topical medication used to treat cold sores, or herpes labialis. It is applied on the affected area of the skin to help reduce the risk of ulcerative cold sores and shorten the healing time of the lesions. This medication is approved for use in adults and children aged 6 years and older. It contains acyclovir and hydrocortisone. There is currently no generic version of Xerese available. The average retail price of Xerese is $1,659.79 or 1, 5gm of 5-1% tube. SingleCare may help you to reduce this price to $1,322.73 for 1, 5gm of 5-1% tube of generic Xerese with a SingleCare Xerese coupon. This coupon can be redeemed at participating pharmacies, such as CVS Pharmacy, Target, Walmart Pharmacy, Kroger, Rite Aid, and Walgreens.
The average cash price of Xerese without insurance coverage is $1,659.79 for 1, 5gm of 5-1% tube or more. SingleCare can help you save on this total with a Xerese coupon. You may be able to pay $1,322.73 per 1, 5gm of 5-1% tube when you use SingleCare's Xerese prescription savings card or coupon at participating drugstores like Harris Teeter, Walgreens, and Duane Reade.
Xerese may have varying costs based on the type of health insurance plan that you have. Contact your insurance provider directly to find out how much Xerese costs with your plan. For people who don’t have insurance or those who have insufficient insurance coverage for Xerese, SingleCare is a potential savings option. Try a SingleCare Xerese coupon, which may lower the cost of your Xerese prescription fill to $1,322.73 for 1, 5gm of 5-1% tube of generic Xerese at participating pharmacies.
Xerese is not generally covered by Medicare insurance plans. If you have Medicare, you may have to pay the full cash price total of $1,659.79 for 1, 5gm of 5-1% tube. SingleCare may help you reduce this total with a Xerese prescription discount card. This free discount card can be used at participating neighborhood pharmacies and could allow you to pay our lowest price of $1,322.73 1, 5gm of 5-1% tube of generic Xerese for your Xerese prescription.
Xerese is a brand-name prescription drug manufactured by Bausch Health. There is no generic version of Xerese currently available on the market.
Xerese is a brand-name topical medication used to treat cold sores, which are caused by the herpes simplex virus. It is available as a topical cream that contains a combination of acyclovir and hydrocortisone. This combination of drugs works together to stop the growth of the virus and relieve symptoms of itching, pain, and burning. Xerese helps to speed up the healing of cold sores but does not cure herpes or prevent passing the infection to someone else.
Xerese is meant for external use on the skin only. Use this medication at the first sign of a cold sore. Clean and dry the affected area before applying this medication. Apply a thin layer of this medication to the affected area, usually five times a day for up to five days. Apply enough of this cream to cover the entire affected area.
Do not apply other skin products such as make-up or sunscreen to the area where you have used this drug. You should also avoid showering for up to 30 minutes after using this medication. This will help to prevent the medication from getting washed off. Avoid getting this cream into your eyes, nose, mouth, or ears. If it does get into any of these areas, flush with plenty of water. Use this medication as prescribed by a doctor.
Common side effects of Xerese include reactions around the site of application which may include drying or flaking of the skin, burning, redness, stinging, changes in skin color, and itching. Consult with your doctor or pharmacist if you experience any of these effects and they persist or worsen. Many patients using this medication do not have any serious side effects.
Serious allergic reactions to this medication are usually rare. However, you should seek immediate medical attention if you begin to experience symptoms of a serious allergic reaction, such as itching, rash, swelling of the face or throat, and severe dizziness,
This is not a complete list of side effects. Consult your doctor or healthcare professional for additional information and medical advice regarding other possible side effects or drug interactions. You can report negative side effects to the FDA.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved