Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD). The active ingredient in Yupelri, revefenacin, is a bronchodilator. It works by preventing the nerves from signaling the muscles in the lung's airways to contract. Because these muscles do not contract, the bronchi, or airways, stay open so that air can pass through. Yupelri opens airways for about 24 hours. Yupelri is administered through a nebulizer. On average, the retail price of Yupelri is $45.04 for 1, 175mcg/3ml solution (quantity in ml), but only costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri with a SingleCare Yupelri coupon. Many local pharmacies–CVS, Target, Longs Drugs, Walgreens, and Duane Reade–accept SingleCare.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD). The active ingredient in Yupelri, revefenacin, is a bronchodilator. It works by preventing the nerves from signaling the muscles in the lung's airways to contract. Because these muscles do not contract, the bronchi, or airways, stay open so that air can pass through. Yupelri opens airways for about 24 hours. Yupelri is administered through a nebulizer. On average, the retail price of Yupelri is $45.04 for 1, 175mcg/3ml solution (quantity in ml), but only costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri with a SingleCare Yupelri coupon. Many local pharmacies–CVS, Target, Longs Drugs, Walgreens, and Duane Reade–accept SingleCare.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Yupelri Retail Price | Yupelri SingleCare Price |
|---|---|---|
| CVS Pharmacy | $61.92 | $53.34 |
| Walmart | $64.02 | $54.18 |
| Walgreens | $64.41 | $55.74 |
| Kroger Pharmacy | $63.06 | $50.40 |
| Albertsons Pharmacy | $81.24 | $54.00 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD). The active ingredient in Yupelri, revefenacin, is a bronchodilator. It works by preventing the nerves from signaling the muscles in the lung's airways to contract. Because these muscles do not contract, the bronchi, or airways, stay open so that air can pass through. Yupelri opens airways for about 24 hours. Yupelri is administered through a nebulizer. On average, the retail price of Yupelri is $45.04 for 1, 175mcg/3ml solution (quantity in ml), but only costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri with a SingleCare Yupelri coupon. Many local pharmacies–CVS, Target, Longs Drugs, Walgreens, and Duane Reade–accept SingleCare.
A prescription will cost around $45.04 for 1, 175mcg/3ml solution (quantity in ml) or 1, 175mcg/3ml solution (quantity in ml) for uninsured customers. With a SingleCare Yupelri coupon, you will pay $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri.
Your copay for Yupelri will vary depending on your health insurance plan. Ask your pharmacist to compare your insurance copay to your price with a SingleCare Yupelri coupon. SingleCare may save you more money with SingleCare, Yupelri costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri.
Yupelri is usually not covered by Medicare prescription drug plans, but is often covered under Medicare Part B. Medicare-eligible patients without coverage for Yupelri can save money with SingleCare Yupelri coupons. The price of Yupelri with a SingleCare discount card is $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri.
Yupelri is a brand-name prescription drug with revefenacin as the active ingredient. Generic revefenacin is not currently available.
Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD), a condition that makes breathing difficult.
The active ingredient in Yupelri, revefenacin, belongs to a class of drugs called bronchodilators. These drugs increase the width of the airway passages, making it easier for air to pass through. Revefenacin works by blocking a substance, acetylcholine, which is critical for nerves to signal muscles to contract. As a result, the muscles in the bronchi, or airways, stay relaxed, and the patient does not suffer periodic problems with breathing.
The effects of Yupelri on the airways typically last 24 hours. Yupelri is not used for emergency breathing crises.
Yupelri is administered once daily through a jet nebulizer with a compressor using a mouthpiece.
The most common side effects of Yupelri are site reactions to the aerosol, including cough, runny nose, mouth pain, throat pain, and bronchitis. Other common side effects include, but are not limited to, upper respiratory tract infections, headache, back pain, and dizziness.
The most serious side effects of Yupelri include high blood pressure, bronchospasms, and worsening of glaucoma.
Allergic reactions to Yupelri are rare, but if you experience allergic reactions immediately after inhaling Yupelri, tell your physician, who will discontinue the medication.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved