Yupelri Coupons & Prices

Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD). The active ingredient in Yupelri, revefenacin, is a bronchodilator. It works by preventing the nerves from signaling the muscles in the lung's airways to contract. Because these muscles do not contract, the bronchi, or airways, stay open so that air can pass through. Yupelri opens airways for about 24 hours. Yupelri is administered through a nebulizer. On average, the retail price of Yupelri is $45.04 for 1, 175mcg/3ml solution (quantity in ml), but only costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri with a SingleCare Yupelri coupon. Many local pharmacies–CVS, Target, Longs Drugs, Walgreens, and Duane Reade–accept SingleCare.

Set your location
Get alerted when the price
changes more than 10%

1 inhalation vial for nebulizer3ml of 175mcg/3mlEdit

Unlock members-only prices.Free signup.

You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.

Yupelri coupon at Kroger Pharmacy
$55.22
$ 52.22
$3 off with signupwith signup

Show this free card to your pharmacist.

Coupon card loading
Yupelri coupon at Harris Teeter Pharmacy
$55.22
$ 52.22
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

Members can save even more
and it's free to join

Yupelri coupon at Costco Pharmacy
$59.32
$ 56.32
$3 off with signupwith signup
Yupelri coupon at Walmart Neighborhood Market Pharmacy
$59.52
$ 56.52
$3 off with signupwith signup
Yupelri coupon at Walmart Pharmacy
$59.52
$ 56.52
$3 off with signupwith signup
Yupelri coupon at Publix Pharmacy
$61.69
$ 58.69
$3 off with signupwith signup
$67.12
$ 64.12
$3 off with signupwith signup
$76.08
$ 73.08
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

Members save the most

Save big on your prescriptions
with the free SingleCare app.
4.8 average rating
About Yupelri

Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD). The active ingredient in Yupelri, revefenacin, is a bronchodilator. It works by preventing the nerves from signaling the muscles in the lung's airways to contract. Because these muscles do not contract, the bronchi, or airways, stay open so that air can pass through. Yupelri opens airways for about 24 hours. Yupelri is administered through a nebulizer. On average, the retail price of Yupelri is $45.04 for 1, 175mcg/3ml solution (quantity in ml), but only costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri with a SingleCare Yupelri coupon. Many local pharmacies–CVS, Target, Longs Drugs, Walgreens, and Duane Reade–accept SingleCare.

Yupelri Price History & Information

Price History for Yupelri

1 count, solution (quantity in ml), 175mcg/3ml

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Yupelri

1 count, solution (quantity in ml), 175mcg/3ml
PharmacyYupelri Retail PriceYupelri SingleCare Price
CVS Pharmacy$61.92$53.34
Walmart$64.02$54.18
Walgreens$64.41$55.74
Kroger Pharmacy$63.06$50.40
Albertsons Pharmacy$81.24$54.00

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Yupelri

Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD). The active ingredient in Yupelri, revefenacin, is a bronchodilator. It works by preventing the nerves from signaling the muscles in the lung's airways to contract. Because these muscles do not contract, the bronchi, or airways, stay open so that air can pass through. Yupelri opens airways for about 24 hours. Yupelri is administered through a nebulizer. On average, the retail price of Yupelri is $45.04 for 1, 175mcg/3ml solution (quantity in ml), but only costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri with a SingleCare Yupelri coupon. Many local pharmacies–CVS, Target, Longs Drugs, Walgreens, and Duane Reade–accept SingleCare.

Yupelri FAQs

How much does Yupelri cost without insurance?

A prescription will cost around $45.04 for 1, 175mcg/3ml solution (quantity in ml) or 1, 175mcg/3ml solution (quantity in ml) for uninsured customers. With a SingleCare Yupelri coupon, you will pay $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri.

How much does Yupelri cost with insurance?

Your copay for Yupelri will vary depending on your health insurance plan. Ask your pharmacist to compare your insurance copay to your price with a SingleCare Yupelri coupon. SingleCare may save you more money with SingleCare, Yupelri costs $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri.

Does Medicare cover Yupelri and how much does it cost?

Yupelri is usually not covered by Medicare prescription drug plans, but is often covered under Medicare Part B. Medicare-eligible patients without coverage for Yupelri can save money with SingleCare Yupelri coupons. The price of Yupelri with a SingleCare discount card is $52.22 for 1, 175mcg/3ml solution (quantity in ml) of brand-name Yupelri.

Is there a generic of Yupelri?

Yupelri is a brand-name prescription drug with revefenacin as the active ingredient. Generic revefenacin is not currently available.

What is Yupelri?

Yupelri is a brand-name prescription drug that is taken once a day to keep airways open in patients with chronic obstructive pulmonary disease (COPD), a condition that makes breathing difficult.

The active ingredient in Yupelri, revefenacin, belongs to a class of drugs called bronchodilators. These drugs increase the width of the airway passages, making it easier for air to pass through. Revefenacin works by blocking a substance, acetylcholine, which is critical for nerves to signal muscles to contract. As a result, the muscles in the bronchi, or airways, stay relaxed, and the patient does not suffer periodic problems with breathing.

The effects of Yupelri on the airways typically last 24 hours. Yupelri is not used for emergency breathing crises.

Yupelri is administered once daily through a jet nebulizer with a compressor using a mouthpiece.

What are the side effects of Yupelri?

The most common side effects of Yupelri are site reactions to the aerosol, including cough, runny nose, mouth pain, throat pain, and bronchitis. Other common side effects include, but are not limited to, upper respiratory tract infections, headache, back pain, and dizziness.

The most serious side effects of Yupelri include high blood pressure, bronchospasms, and worsening of glaucoma.

Allergic reactions to Yupelri are rare, but if you experience allergic reactions immediately after inhaling Yupelri, tell your physician, who will discontinue the medication.

Where are Yupelri coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.